{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:31:12Z","timestamp":1793723472212,"version":"4.6.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRCEP"],"published-print":{"date-parts":[[2021,4,29]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Anti-hypertensive medications may reduce the incidence of cognitive\ndisorders. This may be due to reasons beyond their pure hypotensive effect. This study aimed to\nsystematically review the association between the use of Angiotensin-Receptor Blockers (ARBs)\nand the incidence of Alzheimer\u2019s disease (AD).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> We systematically searched studies reporting the association between ARB use and the\nincidence of AD.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Ten studies (1 RCT, 2 case-control and 7 cohort studies) met the inclusion criteria. When\nall observational studies (9) were analyzed, ARB use was associated with a reduced risk of incident\nAD (HR 0.72, 95% CI: 0.58-0.88, p&lt;0.001). In the only RCT, decrease in the incidence of AD was\nalso significant (HR= 0.31, 95% CI: 0.14-0.68).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> ARB use may reduce the risk of incident AD. This association does not imply causation\nand further research is required to clarify potential mechanisms.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574884715666200131120224","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T14:09:17Z","timestamp":1580479757000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Angiotensin-Receptor Blockers and the Risk of Alzheimer\u00b4s Disease: A Meta-analysis"],"prefix":"10.2174","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9379-4767","authenticated-orcid":true,"given":"Teodoro J.","family":"Oscanoa","sequence":"first","affiliation":[{"name":"Centro de Investigacion de Seguridad de Medicamentos de la Facultad de Medicina Humana de la Universidad de San Martin de Porres (FMH-USMP), Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-4650","authenticated-orcid":true,"given":"Jos\u00e9","family":"Amado","sequence":"additional","affiliation":[{"name":"Centro de Investigacion de Seguridad de Medicamentos de la Facultad de Medicina Humana de la Universidad de San Martin de Porres (FMH-USMP), Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-4298","authenticated-orcid":true,"given":"Xavier","family":"Vidal","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, Valld\u2019Hebron Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3882-7447","authenticated-orcid":true,"given":"Roman","family":"Romero-Ortuno","sequence":"additional","affiliation":[{"name":"Trinity College Dublin, Discipline of Medical Gerontology, Mercer\u2019s Institute for Successful Ageing, St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Reviews in Clinical and Experimental Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/178892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/178892\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/178892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T18:59:49Z","timestamp":1621882789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/178892\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,29]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,4,29]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574884715666200131120224","relation":{},"ISSN":["2772-4328"],"issn-type":[{"value":"2772-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4,29]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}