{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T00:25:43Z","timestamp":1794097543883,"version":"4.8.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRCEP"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> Anxiety disorders are the most universal psychiatric problems in the general\npopulation. Due to their chronic nature, these diseases are managed with a multi-drug regimen lasting\nfor a long period of time. Medication discontinuation leads to 25% and 80% recurrence in the first\nmonth and the first year, respectively. Despite several treatment approaches, there is no specific and\noptimal method for patient management. Therefore, it is necessary to find some new therapeutic approaches\nwith fewer side effects. Withania somnifera is a plant with GABAergic property responsible\nfor its anxiolytic effect. The aim of this study was to investigate the effect of W. somnifera root extract\nas an alternative therapy to reduce standard Generalized Anxiety Disorder (GAD) symptoms.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Forty patients who met the inclusion criteria (with a confirmed diagnosis of GAD as\nstated in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision\n(DSM-IV-TR) took part in this randomized double-blind placebo-controlled trial and were randomly\nselected for participation in the treatment group (W. somnifera extract, 1g\/day; n = 22) or the\nplacebo group (n = 18). All patients were under treatment with Selective Serotonin Reuptake Inhibitors\n(SSRIs) and were prescribed one capsule of the extract or placebo per day for six weeks. The\nHamilton anxiety rating scale (HAM-A) was used to assess the severity of GAD symptoms at baseline\nas well as the second and sixth weeks of the trial.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Comparison of the HAM-A scores during the course of the trial revealed a significant amelioration\nofHAM-A score in the treatment group versus placebo (14 and 8 units reduction, respectively\n(P &lt; 0.05)). Moreover, there was a significant difference in the reduction of GAD score between\nthe second (P =0.04) and sixth week (P =0.02) in the treatment group. The extract was safe\nand no adverse effect was observed during the trial.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>W. somnifera extract offers some potential advantages as a safe and effective adjunctive\ntherapy to SSRIs in GAD. The clinical trial protocol has been registered under the Iranian Registry\nof Clinical Trials (IRCT20180615040105N1).<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574884715666200413120413","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T18:53:31Z","timestamp":1586804011000},"page":"191-196","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Assessment of the Efficacy of Withania somnifera Root Extract in Patients with Generalized Anxiety Disorder: A Randomized Double-blind Placebo- Controlled Trial"],"prefix":"10.2174","volume":"16","author":[{"given":"Sara","family":"Fuladi","sequence":"first","affiliation":[{"name":"Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed A.","family":"Emami","sequence":"additional","affiliation":[{"name":"Department of Pharmacogenosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir H.","family":"Mohammadpour","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asieh","family":"Karimani","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali A.","family":"Manteghi","sequence":"additional","affiliation":[{"name":"2Department of Pharmacogenosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Reviews in Clinical and Experimental Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/180848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/180848\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/180848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T16:39:31Z","timestamp":1628613571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/180848\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574884715666200413120413","relation":{},"ISSN":["2772-4328"],"issn-type":[{"value":"2772-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}