{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:24:15Z","timestamp":1765268655387,"version":"3.40.5"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRCEP"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:sec>\n<jats:title>Rationale &amp; Objective:<\/jats:title>\n<jats:p>Rodenticide poisoning, either accidental or intentional, is very\ncommon in rural India. The absence of a definite antidote made it a major concern with a high mortality\nrate. Therefore, this study aimed to assess the effectiveness of N-Acetyl Cysteine (NAC) in\nrodenticide poisoning as there are recent positive shreds of evidence on it.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methodology:<\/jats:title>\n<jats:p>A retrospective study was conducted in a tertiary care teaching hospital on patients\nadmitted with rodenticide poisoning during a period of 2012-2017. The Fischer\u2019s exact test and\nrelative risk were measured to analyze the outcome of treatment and risk factors, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>A total of 229 patients were enrolled in the study with a mean age of 30.04 \u00b1 15.67 years.\nThe suicidal attack was the major (86.0%) reason for poison consumption. The survival rate was\nsignificantly (p \u2264 0.03) higher in the NAC treatment group compared to the non-NAC group.\nMoreover, the majority (93.4%) of participants did not experience any adverse effects. The mean\noral loading dose and maintenance dose was 7580.95 \u00b1 2204.29 mg and 3694.53 \u00b1 2322.58 mg,\nrespectively. Yellow Phosphorus poisoning (Relative Risk [RR] 2.888 (1.179-7.079); p=0.020) and\nTime lag of \u2265 24 hours (RR 3.479 (1.137-10.645); p=0.029) were the significant risk factors for\nmortality.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>NAC is shown to have a significant survival benefit with a good safety profile among\nrodenticide poisoners. Further adequately powered prospective researches with more emphasis on\ndosing parameters are warranted for better quantification in different settings and for clinical implementation.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574884715666200513090634","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T12:11:25Z","timestamp":1589371885000},"page":"201-208","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Survival Benefits of N-Acetylcysteine in Rodenticide Poisoning: Retrospective Evidence from an Indian Tertiary Care Setting"],"prefix":"10.2174","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0754-1219","authenticated-orcid":true,"given":"Karen","family":"Mark","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1744-6581","authenticated-orcid":true,"given":"Shabnam","family":"Hyder","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6390-7764","authenticated-orcid":true,"given":"Muhammed","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3559-1966","authenticated-orcid":true,"given":"Viji P.","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7198-9659","authenticated-orcid":true,"given":"Shubha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4861-9569","authenticated-orcid":true,"given":"Sneha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-3275","authenticated-orcid":true,"given":"Sreedharan","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1257-969X","authenticated-orcid":true,"given":"Girish","family":"Thunga","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, KarnatakaDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Reviews in Clinical and 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