{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:26:22Z","timestamp":1793298382532,"version":"4.5.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"3","funder":[{"DOI":"10.13039\/100007776","name":"Deanship of Research, The University of Jordan, Amman","doi-asserted-by":"publisher","award":["Endorsement Number: 90\/2014-2015"],"award-info":[{"award-number":["Endorsement Number: 90\/2014-2015"]}],"id":[{"id":"10.13039\/100007776","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRCEP"],"published-print":{"date-parts":[[2021,9,22]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>The use of statins to lower high serum cholesterol levels may be associated\nwith a number of adverse reactions, including severe myopathy. The solute carrier organic anion\ntransporter 1B1 (SLCO1B1) gene, which encodes the organic anion-transporting polypeptide OATP1B1,\nis related to the intracellular transport of statins. The aim of this research was to study the association\nof rs2306283 and rs4149056 genetic polymorphism of the SLCO1B1 gene with the development\nof statin-induced myopathy in Jordanian diabetics receiving statins.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>We included 413 patients attending the Diabetes Clinics of the National Center for Diabetes,\nEndocrinology and Genetics, Amman, Jordan. The study was approved by the Institutional\nReview Board of NCDEG. Myopathy was defined as the elevation of creatine kinase more than 3\ntimes the upper limit of normal. Every subject signed an informed consent form and donated 3-5\nmL of venous blood. Genome DNA was extracted from lymphocytes of peripheral blood. Genotypes\nwere identified using the Tetra Amplification Refractory Mutation System of SLCO1B1.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> The minor allele frequencies of rs2306283 [G] and rs4149056 [C] were 0.38 and 0.23, respectively.\nThe two SNPs followed the Hardy-Weinberg equilibrium. The development of SIM\nwas significantly associated with the homozygous and heterozygous minor allele genotype of\nrs4149056 (CC and CT), and the homozygous wild type allele genotype of rs2306283 (AA). There\nwas no linkage disequilibrium between the two SNPs in the studied subgroups.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>Genetic polymorphism in the SLCO1B1 Gene is a risk factor for the development of\nSIM in Jordanian patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574884715666200827105612","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T12:20:29Z","timestamp":1598703629000},"page":"281-288","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["SLCO1B1 Gene Polymorphisms (rs2306283 and rs4149056) and Statin-Induced Myopathy in Jordanian Diabetics"],"prefix":"10.2174","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9956-5516","authenticated-orcid":true,"given":"Zaineh M.","family":"Shahrure","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Medicine, the University of Jordan, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3744-7837","authenticated-orcid":true,"given":"Yacoub M.","family":"Irshaid","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine, the University of Jordan, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3260-5528","authenticated-orcid":true,"given":"Khader N.","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, the University of Jordan, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5836-5000","authenticated-orcid":true,"given":"Mousa A.","family":"Abujbara","sequence":"additional","affiliation":[{"name":"The National Center for Diabetes, Endocrinology, and Genetics, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0160-8264","authenticated-orcid":true,"given":"Mohammad","family":"Al Shhab","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine, the University of Jordan, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-2287","authenticated-orcid":true,"given":"Mohammed S.","family":"El-Khateeb","sequence":"additional","affiliation":[{"name":"The National Center for Diabetes, Endocrinology, and Genetics, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel M.","family":"Ajlouni","sequence":"additional","affiliation":[{"name":"The National Center for Diabetes, Endocrinology, and Genetics, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Reviews in Clinical and Experimental Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/185357","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/185357\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/185357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T12:54:50Z","timestamp":1632833690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/185357\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,22]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9,22]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574884715666200827105612","relation":{},"ISSN":["2772-4328"],"issn-type":[{"value":"2772-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,22]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}