{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T10:55:59Z","timestamp":1756810559595},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRCEP"],"published-print":{"date-parts":[[2021,9,22]]},"abstract":"<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Systemic administration of anti-Vascular Endothelial Growth Factors (anti-\nVEGFs) has been associated with severe cardiovascular adverse events in oncologic patients.\nThe purpose of this pilot study is to evaluate the short-term effect of a single intravitreal injection\nof aflibercept on biomarkers related to increased risk of cardiovascular disease.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Patients and Methods:<\/jats:title>\n<jats:p>Forty-seven treatment na\u00efve patients with neovascular age-related macular\ndegeneration in one eye were enrolled in the study. The patients underwent treatment with one intravitreal\ninjection of aflibercept in the affected eye. Laboratory biomarkers of cardiovascular disease\nwere evaluated before the first intravitreal injection of aflibercept and at 7 and 30 days after\naflibercept administration. More precisely, we evaluated the levels of homocysteine, total cholesterol,\ntriglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and Creactive\nprotein.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>There was not any statistically significant change in the levels of the evaluated parameters\nup to one month after the first intravitreal injection of aflibercept.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>According to our study, the administration of a single dose of aflibercept in eyes with\nneovascular age-related macular degeneration does not seem to affect the evaluated biomarkers\nthat are related to cardiovascular disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574884715666201016121934","type":"journal-article","created":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T04:53:11Z","timestamp":1602996791000},"page":"289-293","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Intravitreal Injection of Aflibercept on Cardiovascular Risk Parameters in Patients with Neovascular Age-Related Macular Degeneration"],"prefix":"10.2174","volume":"16","author":[{"given":"Constantinos D.","family":"Georgakopoulos","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Patras, Medical School, Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athina","family":"Pallikari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Patras, Medical School, Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Plotas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Patras, Medical School, Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Kagkelaris","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Patras, Medical School, Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stylianos","family":"Mastronikolis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Patras, Medical School, Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Plota","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital of Patras, Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Emmanuil","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital of Patras, Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga E.","family":"Makri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Patras, Medical School, Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Reviews in Clinical and Experimental Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/186925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/186925\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/186925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T12:54:51Z","timestamp":1632833691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/186925\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,22]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9,22]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574884715666201016121934","relation":{},"ISSN":["2772-4328"],"issn-type":[{"value":"2772-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,22]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}