{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:26:55Z","timestamp":1775266015899,"version":"3.50.1"},"reference-count":10,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDS"],"published-print":{"date-parts":[[2019,1,17]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dapsone is a sulfone derived drug used in the treatment of leprosy and several chronic inflammatory dermatological diseases. Dapsone Hypersensitivity Syndrome (DHS) is characterized by fever, hepatitis, generalized exfoliative dermatitis and lymphadenopathy. It is rare and potentially fatal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report:<\/jats:title>\n                    <jats:p>We present a case report of a 52 years old female with a recent history of antecedent dapsone exposure of 100 mg daily for 2 weeks. She developed fever 10 days after exposure to dapsone therapy and was treated in various primary and tertiary centers for features of sepsis. When she presented to us, clinical features of multi-organ dysfunction and intractable sepsis was evident. She was successfully managed with intravenous corticosteroids and other supportive therapy. This case of DHS is unique due to pulmonary, hepatic and colonic involvement in addition to secondary bacterial and fungal infection, which is associated with an increased risk of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>As dapsone is mainstay in the treatment several infections and inflammatory conditions, further research is needed to characterize markers to diagnose DHS and to develop screening policies prior to initiation of dapsone therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1574886313666180731123232","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T01:43:59Z","timestamp":1541641439000},"page":"37-39","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dapsone Hypersensitivity Syndrome (DHS): A Detrimental Effect of Dapsone? A Case Report"],"prefix":"10.2174","volume":"14","author":[{"given":"Aashiq Ahamed","family":"Shukkoor","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saravanan","family":"Thangavelu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, PSG Institute of Medical Science and Research, Coimbatore, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimmy Elizabeth","family":"George","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanmuga","family":"Priya","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, PSG Institute of Medicl Sciences and Research, Coimbatore, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.det.2011.06.018","volume":"29","author":"Piette E.W.","year":"2012","unstructured":"Piette EW, Werth VP. Dapsone in the management of the autoimmune bullous diseases.","journal-title":"Dermatol Clin"},{"key":"ref=2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4103\/2279-042X.185743","volume":"5","author":"Kamal K.S.","year":"2016","unstructured":"Kamal KS, Shyam CC, Jitendra S, Deep CR, Sanjay M, Madhu MG. Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management.","journal-title":"J Res Pharm Pract"},{"key":"ref=3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4103\/0976-500X.110917","volume":"4","author":"Kolar V.V.","year":"2013","unstructured":"Kolar VV, Karyampundi A, Tarun KD. 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A review on dapsone hypersensitivity syndrome among Chinese patients with an emphasis on preventing adverse drug reaction with genetic testing.","journal-title":"Am J Trop Med Hyg"},{"key":"ref=7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1365-2125.1989.tb03517.x","volume":"28","author":"Coleman M.D.","year":"1989","unstructured":"Coleman MD, Breckenridge AM, Park BK. Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes.","journal-title":"Br J Clin Pharmacol"},{"key":"ref=8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/FPC.0000000000000306","volume":"27","author":"Tempark T.","year":"2017","unstructured":"Tempark T, Satapornpong P, Rerknimitr P. Dapsone-induced severe cutaneous adverse drug reactions are strongly linked with HLA-B*13: 01 allele in the Thai population.","journal-title":"Pharmacogenet Genomics"},{"key":"ref=9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1745-6673-1-9","volume":"1","author":"Semaan G.K.","year":"2006","unstructured":"Semaan GK, Bhuvana G, Dima NN, David SC, Guhan K. The dapsone hypersensitivity syndrome revisited: A potentially fatal multisystem disorder with prominent hepatopulmonary manifestations.","journal-title":"J Occup Med Toxicol"},{"key":"ref=10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00403-013-1409-7","volume":"306","author":"Wozel G.","year":"2014","unstructured":"Wozel G, Blasum C. Dapsone in dermatology and beyond.","journal-title":"Arch Dermatol Res"}],"container-title":["Current Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/164203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:22:40Z","timestamp":1775262160000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/164203\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,17]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,17]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574886313666180731123232","relation":{},"ISSN":["1574-8863"],"issn-type":[{"value":"1574-8863","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1,17]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}