{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T20:26:55Z","timestamp":1685392015565},"reference-count":21,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDS"],"published-print":{"date-parts":[[2019,1,17]]},"abstract":"<jats:sec>\n<jats:title>Objective: <\/jats:title>\n<jats:p>Extrapyramidal adverse effects of antipsychotic drugs are more reported in\nchildren. Biperiden is an anticholinergic agent to treat the adverse effects of antipsychotic drugs. The\ndrug has the potential to induce delirium at toxic doses. However, data are scarce about delirium\nassociated with biperiden in children. Thus far, a case of delirium has been associated with biperiden in\nan adolescent patient. We report the first case of delirium associated with the use of biperiden in a\npreadolescent patient.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Case Report: <\/jats:title>\n<jats:p>A boy aged five years and weighing 20 kilograms had been diagnosed as having\noppositional defiant disorder and separation anxiety disorder in the previous treatment center. Ten\nmilligrams fluoxetine and 0.25 milligrams risperidone had been initiated. On the third day of treatment,\ndystonia developed and he was administered with biperiden. An hour later, he was brought to our\nemergency clinic due to disorganized speech and behavior. His vital signs were stable. There were no\nfindings in blood and urine tests. No electrolyte imbalance, liver, kidney, and thyroid dysfunction have\nbeen observed. His neurologic examination was unremarkable and no abnormal findings were shown\non cranial magnetic resonance imaging. No other system findings or findings pointing out to infectious\ndiseases have been observed. One milligram physostigmine was administered with intravenous\ninfusion. However, symptoms did not resolve and he was diagnosed with delirium. Naranjo Adverse Drug\nReaction Probability Scale score was seven, indicating a \u201cProbable\u201d Adverse Drug Reaction. Half\nmilligram haloperidol was administered bid for three days and he was discharged with complete recovery.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>Clinicians must be aware of the risk of delirium when using non-toxic doses of biperiden\nin young children.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574886313666181029101830","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T02:39:39Z","timestamp":1540953579000},"page":"48-50","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biperiden-Induced Delirium In A Five-Years Old Child"],"prefix":"10.2174","volume":"14","author":[{"given":"Duygu","family":"K\u0131nay","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Bilecik State Hospital, Bilecik, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Zihni","family":"Soyata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Ergani State Hospital, Diyarbak\u0131r, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/WNP.0b013e3182a73e31","volume":"30","author":"Neufeld K.J.","year":"2013","unstructured":"Neufeld KJ, Thomas C.  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Biperiden-induced delirium in an adolescent patient.","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"ref=5","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/CCM.0b013e3182a66b76","volume":"42","author":"Traube C.","year":"2014","unstructured":"Traube C, Silver G, Kearney J.  Cornell assessment of pediatric delirium: A valid, rapid, observational tool for screening delirium in the PICU.","journal-title":"Crit Care Med"},{"key":"ref=6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","volume":"30","author":"Naranjo C.A.","year":"1981","unstructured":"Naranjo CA, Busto U, Sellers EM.  A method for estimating the probability of adverse drug reactions.","journal-title":"Clin Pharmacol Ther"},{"key":"ref=7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/01.CHI.0000037049.04952.9F","volume":"42","author":"Birmaher B.","year":"2003","unstructured":"Birmaher B, Axelson DA, Monk K.  Fluoxetine for the treatment of childhood anxiety disorders.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"ref=8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/cap.2005.15.311","volume":"15","author":"Biederman J.","year":"2005","unstructured":"Biederman J, Mick E, Dougherty M, Aleardi M, Wozniak J.  An open-label trial of risperidone in children and adolescents with bipolar disorder.","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"ref=9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0166-2236(98)01361-7","volume":"22","author":"Perry E.","year":"1999","unstructured":"Perry E, Walker M, Grace J, Perry R.  Acetylcholine in mind: A neurotransmitter correlate of consciousness?","journal-title":"Trends Neurosci"},{"key":"ref=10","first-page":"225","volume":"4","author":"Campbell N.","year":"2009","unstructured":"Campbell N, Boustani M, Limbil T, Ott C, Fox C, Maidment I.  The cognitive impact of anticholinergics: A clinical review.","journal-title":"Clin Interv Aging"},{"key":"ref=11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/BF00615970","volume":"29","author":"Grimaldi R.","year":"1986","unstructured":"Grimaldi R, Perucca E, Rubero G.  Pharmacokinetic and pharmacodynamic studies following the intravenous and oral administration of the antiparkinsonian drug biperiden to normal subjects.","journal-title":"Eur J Clin Pharmacol"},{"key":"ref=12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1055\/s-2007-1001778","volume":"56","author":"Hewer W.","year":"1988","unstructured":"Hewer W, Biedert S.  Delirium syndrome in biperiden poisoning in German.","journal-title":"Fortschr Neurol Psychiatr"},{"key":"ref=13","author":"Kojima T.","year":"2000","unstructured":"Kojima T, Matsushima E, Ando K.","journal-title":"Eyes and the mind"},{"key":"ref=14","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.brainres.2006.07.061","volume":"1115","author":"Tamura Y.","year":"2006","unstructured":"Tamura Y, Chiba S, Takasaki H, Tabata K, Ishimaru Y, Ishimoto T.  Biperiden-induced delirium model in rats: A behavioral and electroencephalographic study.","journal-title":"Brain Res"},{"key":"ref=15","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.1176\/jnp.2010.22.2.247.e15","volume":"22","author":"Shinohara Y.","year":"2010","unstructured":"Shinohara Y.  Delirium caused by intramuscular administration of biperiden.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"ref=16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.archger.2007.01.027","volume":"44","author":"Gareri P.","year":"2007","unstructured":"Gareri P, De Fazio P, Cotroneo A.  Anticholinergic drug-induced delirium in an elderly Alzheimer\u2019s dementia patient.","journal-title":"Arch Gerontol Geriatr"},{"key":"ref=17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/MOP.0b013e32802c7be1","volume":"19","author":"Frascogna N.","year":"2007","unstructured":"Frascogna N.  Physostigmine: Is there a role for this antidote in pediatric poisonings?","journal-title":"Curr Opin Pediatr"},{"key":"ref=18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/15563650.2013.773006","volume":"51","author":"Hail S.L.","year":"2013","unstructured":"Hail SL, Obafemi A, Kleinschmidt KC.  Successful management of olanzapine-induced anticholinergic agitation and delirium with a continuous intravenous infusion of physostigmine in a pediatric patient.","journal-title":"Clin Toxicol (Phila)"},{"key":"ref=19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2190\/PM.39.2.f","volume":"39","author":"Grover S.","year":"2009","unstructured":"Grover S, Malhotra S, Bharadwaj R, Bn S, Kumar S.  Delirium in children and adolescents.","journal-title":"Int J Psychiatry Med"},{"key":"ref=20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00006842-198001001-00012","volume":"42","author":"Prugh D.G.","year":"1980","unstructured":"Prugh DG, Wagonfield S, Metcalf D, Jordan K.  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