{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T04:10:04Z","timestamp":1721016604182},"reference-count":31,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDS"],"published-print":{"date-parts":[[2019,5,22]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Some studies have linked the use of paracetamol (PAR) with adverse effects like wheezing, exacerbation of asthma symptoms and other respiratory problems. Other studies are inconclusive or deny this correlation. This makes the association between PAR and airway hypersensitivity very controversial and still under debate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>This work investigated if chronic treatment with PAR in rats could directly affect the contraction and relaxation for different stimulus in isolated airways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Rats were treated for 2 weeks with PAR (400 mg\/Kg, v.o.). The blood was collected for biochemical analysis (alanine aminotransferase (ALT), aspartate aminotransferase (AST), TBARs reaction and glutathione) and isolated tracheal rings were prepared in organ bath to measure isometric tone after contractile and relaxant stimulus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Hepatic enzymes (ALT, AST) and lipid peroxidation were increased after PAR-treatment, while glutathione was decreased. Rats do not present any alteration in airway myocytes responsiveness, either to contractile or relaxant stimulus (i.e. cholinergic agonist, membrane depolarization, Ca2+ influx across sarcolemma, internal Ca2+ release from sarcoplasmic reticulum, Ca2+ channel blocking, \u03b2-agonist and NOmediating relaxation).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Despite increased oxidative stress and reduced antioxidant defense, chronic treatment with PAR does not induce airway hypersensitivity or risk of asthma in rats.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1574886314666190222194841","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T11:07:28Z","timestamp":1551179248000},"page":"109-115","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment with Paracetamol is not Associated with Increased Airway Sensitivity and Risk of Asthma in Rats"],"prefix":"10.2174","volume":"14","author":[{"given":"Marco T\u00falio","family":"Lacerda Ribeiro","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Federal University of Goias, Avenida Universitaria s\/n, 74605-220, Goiania, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hellen Karine","family":"Paes Porto","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Federal University of Goias, Avenida Universitaria s\/n, 74605-220, Goiania, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Fernandes","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, University Hospital, Federal University of Goias, 1\u00aa Avenida, s\/n, 74605-020, Goiania, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Ferreira","family":"da Silva Castro","sequence":"additional","affiliation":[{"name":"Itumbiara Campus, State University of Goias, Avenida Modesto de Carvalho, s\/n, Distrito Agoindustrial, Itumbiara 75536-100, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Lavorenti","family":"Rocha","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Federal University of Goias, Avenida Universitaria s\/n, 74605-220, Goiania, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1586\/17512433.2014.904744","volume":"3","author":"Blieden M.","year":"2014","unstructured":"Blieden M, Paramore LC, Shah DD, Ben-Joseph R. Expert Rev Clin Pharmacol, A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States.,, 2014, 3,, 341-348,","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref=2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/ard.2011.200087","volume":"71","author":"Hinz B.","year":"2012","unstructured":"Hinz B, Brune K. Ann Rheum Dis, Paracetamol and cyclooxygenase inhibition: Is there a cause for concern.,, 2012, 71,, 20-25,","journal-title":"Ann Rheum Dis"},{"key":"ref=3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cbi.2015.05.023","volume":"238","author":"Zheng Z.","year":"2015","unstructured":"Zheng Z, Sheng Y, Lu B, Ji L. Chem Biol Interact, The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation.,, 2015, 238,, 93-101,","journal-title":"Chem Biol Interact"},{"key":"ref=4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/bcp.12635","volume":"80","author":"Gulmez S.E.","year":"2015","unstructured":"Gulmez SE, Larrey D, Pageaux GP. Br J Clin Pharmacol, Liver transplant associated with paracetamol overdose: Results from the seven-country SALT study.,, 2015, 80,, 599-606,","journal-title":"Br J Clin Pharmacol"},{"key":"ref=5","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1542\/peds.2008-2869","volume":"124","author":"Vernacchio L.","year":"2009","unstructured":"Vernacchio L, Kelly JP, Kaufman DW, Mitchell AA. Pediatrics, Medication use among children <12 years of age in the United States: Results from the Slone survey.,, 2009, 124,, 446-454,","journal-title":"Pediatrics"},{"key":"ref=6","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1164\/rccm.200409-1269OC","volume":"171","author":"McKeever T.M.","year":"2005","unstructured":"McKeever TM, Lewis SA, Smit HA, Burney P, Britton JR, Cassano PA. Am J Respir Crit Care Med, The association of acetaminophen, aspirin, and ibuprofen with respiratory disease and lung function.,, 2005, 171,, 966-971,","journal-title":"Am J Respir Crit Care Med"},{"key":"ref=7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1164\/rccm.201005-0757OC","volume":"183","author":"Beasley R.W.","year":"2011","unstructured":"Beasley RW, Clayton TO, Crane J. Am J Respir Crit Care Med, Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International study of asthma and allergies in childhood phase three.,, 2011, 183,, 171-178,","journal-title":"Am J Respir Crit Care Med"},{"key":"ref=8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1046\/j.1365-2710.2003.00493.x","volume":"28","author":"Nuttall S.L.","year":"2003","unstructured":"Nuttall SL, Khan JN, Thorpe GH, Langford N, Kendall MJ. J Clin Pharm Ther, The impact of therapeutic doses of paracetamol on serum total antioxidant capacity.,, 2003, 28,, 289-294,","journal-title":"J Clin Pharm Ther"},{"key":"ref=9","doi-asserted-by":"crossref","first-page":"E20","DOI":"10.1542\/peds.109.2.e20","volume":"109","author":"Lesko S.M.","year":"2002","unstructured":"Lesko SM, Louik C, Vezina RM, Mitchell AA. Pediatrics, Asthma morbidity after the short-term use of ibuprofen in children.,, 2002, 109,, E20-,","journal-title":"Pediatrics"},{"key":"ref=10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2222.2009.03378.x","volume":"40","author":"Farquhar H.","year":"2010","unstructured":"Farquhar H, Stewart A, Mitchell E. Clin Exp Allergy, The role of paracetamol in the pathogenesis of asthma.,, 2010, 40,, 32-41,","journal-title":"Clin Exp Allergy"},{"key":"ref=11","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/pds.3940","volume":"25","author":"Liu X.","year":"2016","unstructured":"Liu X, Liew Z, Olsen J. Pharmacoepidemiol Drug Saf, Association of prenatal exposure to acetaminophen and coffee with childhood asthma.,, 2016, 25,, 188-195,","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref=12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/02770903.2016.1194431","volume":"54","author":"Lourido-Cebreiro T.","year":"2017","unstructured":"Lourido-Cebreiro T, Salgado FJ, Valdes L, Gonzalez-Barcala FJ. J Asthma, The association between paracetamol and asthma is still under debate.,, 2017, 54,, 32-38,","journal-title":"J Asthma"},{"key":"ref=13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/ACI.0000000000000026","volume":"14","author":"Kim H.","year":"2014","unstructured":"Kim H, Johnson CC. Curr Opin Allergy Clin Immunol, The association between acetaminophen and asthma - is there anything to learn from the upper airways.,, 2014, 14,, 25-28,","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"ref=14","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/cea.12410","volume":"45","author":"Weatherall M.","year":"2015","unstructured":"Weatherall M, Loannides S, Braithwaite I, Beasley R. Clin Exp Allergy, The association between paracetamol use and asthma: Causation or coincidence.,, 2015, 45,, 108-113,","journal-title":"Clin Exp Allergy"},{"key":"ref=15","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1056\/NEJMoa1515990","volume":"18","author":"Sheehan W.J.","year":"2016","unstructured":"Sheehan WJ, Mauger DT, Paul IM. N Engl J Med, Acetaminophen versus ibuprofen in young children with mild persistent asthma.,, 2016, 18,, 619-630,","journal-title":"N Engl J Med"},{"key":"ref=16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/1440-1681.12523","volume":"43","author":"Castro P.F.S.","year":"2016","unstructured":"Castro PFS, Andrade DL, Reis CF. Clin Exp Pharmacol Physiol, Relaxing effect of a new ruthenium complex nitric oxide donor on airway smooth muscle of an experimental model of asthma in rats.,, 2016, 43,, 221-229,","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref=17","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"Reagan-Shaw S.","year":"2008","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N. FASEB J, Dose translation from animal to human studies revisited.,, 2008, 22,, 659-661,","journal-title":"FASEB J"},{"key":"ref=18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2165\/00003495-198325030-00002","volume":"25","author":"Prescott L.F.","year":"1983","unstructured":"Prescott LF. Drugs, Paracetamol overdosage. Pharmacological considerations and clinical management.,, 1983, 25,, 290-314,","journal-title":"Drugs"},{"key":"ref=19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","volume":"28","author":"Reitman S.","year":"1957","unstructured":"Reitman S, Frankel S. Am J Clin Pathol, A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.,, 1957, 28,, 56-63,","journal-title":"Am J Clin Pathol"},{"key":"ref=20","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1152\/jappl.1995.79.4.1271","volume":"79","author":"De Castro C.M.","year":"1995","unstructured":"De Castro CM, Bureau MF, Nahori MA, Dumarey CH, Vargaftig BB, Bachelet M. J Appl Physiol, Modulation by dexamethasone of phospholipase A2 activities in endotoxemic guinea pigs.,, 1995, 79,, 1271-1277,","journal-title":"J Appl Physiol"},{"key":"ref=21","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1093\/ageing\/afs199","volume":"42","author":"Abdulla A.","year":"2013","unstructured":"Abdulla A, Adams N, Bone M. Age Ageing, Guidance on the management of pain in older people.,, 2013, 42,, i1-i57,","journal-title":"Age Ageing"},{"key":"ref=22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/jama.287.3.337","volume":"287","author":"Kaufman D.M.","year":"2002","unstructured":"Kaufman DM, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA. JAMA, Recent patterns of medication use in the ambulatory adult population of the United States - The slone survey.,, 2002, 287,, 337-344,","journal-title":"JAMA"},{"key":"ref=23","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1248\/bpb.31.1523","volume":"31","author":"Wu Y.L.","year":"2008","unstructured":"Wu YL, Piao DM, Han XH, Nan JX. Biol Pharm Bull, Protective effects of salidroside against acetaminophen-induced toxicity in mice.,, 2008, 31,, 1523-1529,","journal-title":"Biol Pharm Bull"},{"key":"ref=24","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2131\/jts.40.837","volume":"40","author":"Ishii I.","year":"2015","unstructured":"Ishii I, Kamata S, Hagiya Y, Abiko Y, Kasahara T, Kumagai Y. J Toxicol Sci, Protective effects of hydrogen sulfide anions against acetaminophen-induced hepatotoxicity in mice.,, 2015, 40,, 837-841,","journal-title":"J Toxicol Sci"},{"key":"ref=25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S1043-6618(03)00226-3","volume":"48","author":"","year":"2003","unstructured":". Pharmacol Res, Mostafa AM, Al-Shabanah OA, Al-Bekairi AM, Nagi MN. Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice.,Gamal El-din AM, 2003, 48,, 631-635,","journal-title":"Pharmacol Res"},{"key":"ref=26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1183\/09031936.00202013","volume":"43","author":"Chung K.F.","year":"2014","unstructured":"Chung KF, Wenzel SE, Brozek JL. Eur Respir J, International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma.,, 2014, 43,, 343-373,","journal-title":"Eur Respir J"},{"key":"ref=27","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1016\/S0006-3495(04)74313-1","volume":"86","author":"Roux E.","year":"2004","unstructured":"Roux E, Marhl M. Biophys J, Role of sarcoplasmic reticulum and mitochondria in Ca2+ removal in airway myocytes.,, 2004, 86,, 2583-2595,","journal-title":"Biophys J"},{"key":"ref=28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1183\/09031936.00167007","volume":"32","author":"Tazzeo T.","year":"2008","unstructured":"Tazzeo T, Zhang Y, Keshavjee S, Janssen LJ. Eur Respir J, Ryanodine receptors decant internal Ca2+ store in human and bovine airway smooth muscle.,, 2008, 32,, 275-284,","journal-title":"Eur Respir J"},{"key":"ref=29","first-page":"1215","volume":"280","author":"Ellis J.L.","year":"1997","unstructured":"Ellis JL. J Pharmacol Exp Ther, Role of soluble guanylyl cyclase in the relaxations to a nitric oxide donor and to nonadrenergic nerve stimulation in guinea pig trachea and human bronchus.,, 1997, 280,, 1215-1218,","journal-title":"J Pharmacol Exp Ther"},{"key":"ref=30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0014-2999(86)90586-8","volume":"131","author":"Ilhan M.","year":"1986","unstructured":"Ilhan M, Sahin I. Eur J Pharmacol, Tracheal epithelium releases a vascular smooth muscle relaxant factor: Demonstration by bioassay.,, 1986, 131,, 293-296,","journal-title":"Eur J Pharmacol"},{"key":"ref=31","doi-asserted-by":"crossref","first-page":"L273","DOI":"10.1152\/ajplung.00351.2013","volume":"307","author":"Danielsson J.","year":"2014","unstructured":"Danielsson J, Yim P, Rinderspacher A. Am J Physiol Lung Cell Mol Physiol, Chloride channel blockade relaxes airway smooth muscle and potentiates relaxation by \u03b2-agonists.,, 2014, 307,, L273-L282,","journal-title":"Am J Physiol Lung Cell Mol Physiol"}],"container-title":["Current Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/170190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T03:51:03Z","timestamp":1721015463000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/170190\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,5,22]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574886314666190222194841","relation":{},"ISSN":["1574-8863"],"issn-type":[{"value":"1574-8863","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}