{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:15:40Z","timestamp":1781554540968,"version":"3.54.5"},"reference-count":17,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDS"],"published-print":{"date-parts":[[2020,6,19]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Psoriatic Arthritis (PsA) is a chronic inflammatory disease that may affect\ndifferent joints. Sarcoidosis is a Th-1 cell-related chronic granulomatous disease characterized by\nnon-caseating granuloma formation. The coexistence of both the diseases is a rare entity. Ustekinumab,\nan IL12 \/ 23 inhibitor, has shown efficacy and safety in the treatment of PsA.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study presents a case with ustekinumab-induced sarcoidosis in a patient with PsA.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case Report:<\/jats:title>\n<jats:p>A 52 years old female patient with complaints of pain and swelling of the wrists,\nMCP, PIP and DIP joints and skin lesions was referred to our Rheumatology clinic. On her medical\nhistory, she had been under follow up for 5 years with the diagnosis of psoriasis and one year ago, she\nstarted to receive ustekinumab prescribed by a dermatologist. On physical examination, she had psoriasis\nskin lesions and arthritis of both wrists, MCP, PIP, DIP joints. Bilateral hilar lymphadenopathies\nwere detected in the chest X-ray and thorax computed tomography. In laboratory tests, acute phase reactants\nand serum angiotensin-converting enzyme levels were high. Endobronchial ultrasonography\nbiopsy was performed and non-caseating granuloma consistent with sarcoidosis was reported. Ustekinumab\nwas discontinued, methotrexate and low-dose corticosteroid were started. The patient was clinically\nstable in the 6th month of the treatment and the findings were regressed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Sarcoidosis development appears to be a new paradoxical effect of ustekinumab therapy,\nbeing another biological agent.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574886315666200316113312","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T13:48:00Z","timestamp":1584366480000},"page":"163-166","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ustekinumab-induced Sarcoidosis in a Patient with Psoriatic Arthritis"],"prefix":"10.2174","volume":"15","author":[{"given":"Senol","family":"Kobak","sequence":"first","affiliation":[{"name":"Istinye University, Faculty of Medicine, LIV Hospital, Department of Internal Medicine and Rheumatology, WASOG Sarcoidosis Clinic, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Semiz","sequence":"additional","affiliation":[{"name":"Ege University Faculty of Medicine, Department of Internal Medicine, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1056\/NEJM199704243361706","volume":"336","author":"Newman L.S.","year":"1997","unstructured":"Newman L.S.; Rose C.S.; Maier L.A.; Sarcoidosis. 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