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However, it has been described heterogeneously in the literature.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study aims to systematically review epidemiological studies dealing with druginduced\nsudden death, describe their methodologies, and summarize the results found.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>A scoping review has been carried out using Medline electronic database. The search\nwas limited up to 2020. Epidemiological studies were included, and case reports or case series\nwere excluded.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Out of 3,114 potential articles, 74 were included. Most studies originated from North\nAmerica (40.5%) or Europe (39.2%). Case-control (47.3%) or cohort (40.5%) studies were the\nmost common designs. The data for outcomes and exposure were retrieved mainly from administrative\ndatabases (37.8%) or medical charts\/hospital discharge reports (32.4%), but most studies\nused several sources of information. A composite variable of sudden death or SCD, mainly with\nventricular arrhythmia, was the most frequently used endpoint. Only 18.9% of the studies included\nautopsy results to confirm the death. Psychotropic drugs were the most frequently studied. An increased\nrisk of different outcomes for typical antipsychotics, tricyclic antidepressants, domperidone,\nand antiepileptics is suggested.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The methodologies used were highly heterogeneous, and the results were, in general,\nnot conclusive. An improvement of the methodologies is needed to achieve a conclusion regarding\nthe risk of SCD associated with drug use.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574886317666220525115232","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T05:00:21Z","timestamp":1653627621000},"page":"307-317","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Drug-induced Sudden Death: A Scoping Review"],"prefix":"10.2174","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3801-1568","authenticated-orcid":true,"given":"Kristopher","family":"Amaro-Hosey","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"},{"name":"Department of Pharmacology,\nTherapeutics and Toxicology, Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain"},{"name":"TransLab Research Group, Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona,\nSpain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-7273","authenticated-orcid":true,"given":"Xavier","family":"Castells","sequence":"additional","affiliation":[{"name":"Department of Pharmacology,\nTherapeutics and Toxicology, Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2281-3056","authenticated-orcid":true,"given":"Lidia","family":"Blanco-Silvente","sequence":"additional","affiliation":[{"name":"TransLab Research Group, Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona,\nSpain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-539X","authenticated-orcid":true,"given":"Pablo","family":"Loma-Osorio","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Faculty of Medicine, Cardiology Service, Hospital Universitari Josep Trueta,\nUniversity of Girona, Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9137-6972","authenticated-orcid":true,"given":"Dolors","family":"Capell\u00e0","sequence":"additional","affiliation":[{"name":"TransLab Research Group, Department of Medical Sciences, Faculty of Medicine, University of Girona, Girona,\nSpain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.rec.2012.03.025","volume":"65","author":"Bay&#xE9;s de Luna A.","year":"2012","unstructured":"Bay&#xE9;s de Luna A.; Elosua R.; Sudden death. 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