{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T08:31:26Z","timestamp":1709022686329},"reference-count":33,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDS"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n<jats:title>Backgrounds:<\/jats:title>\n<jats:p>Aspergillosis is a severe and fatal complication that causes infection in\ntransplant recipients and patients with immunodeficiency syndrome, neutropenia, chronic granulomatosis,\nand hematologic malignancies. Invasive Aspergillosis has been reported as one of the\nfungal infections with high mortality in transplant recipients. This study aimed to describe the\nmanifestations, prevalence, management and outcome of invasive Aspergillosis fungal infections in\nliver transplant patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>This descriptive cross-sectional study was conducted on patients with liver transplantation\nwho were infected with invasive Aspergillosis fungal infections. The data were extracted from\nthe medical records of the archive of Montasryieh Hospital, Mashhad, Iran, between August 2019\nand August 2020.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>In general, 86 patients who had liver transplantation were hospitalized at Montasryieh\nHospital from August 2019 to August 2020. Among them, 10 patients were infected with invasive\nAspergillosis. Only 6.7% of the patients were categorized under late-onset (&gt; 90 days after liver\ntransplantation), and 93.3% of them were early-onset (&lt; 90 days after liver transplantation). Invasive\nAspergillosis fungal infections were suspected based on clinical or radiological signs (possible\nin 30% of cases; n = 3). The probable diagnosis was reported in 60% (n = 6), and the proven diagnosis\nwas observed only in one patient. In addition, 80% of the patients were diagnosed with Pulmonary\nAspergillosis, and two patients had pulmonary Aspergillosis in combination with the central\nnervous system and cutaneous Aspergillosis. A correlation was found between a comorbid disease\nand the type of Aspergillosis (r = 0.69; P = 0.02). Voriconazole was effective to treat invasive\nAspergillosis in all patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The prevalence rate of Aspergillosis is relatively high among liver transplant recipient\npopulations (11%). All recipients infected with Aspergillosis had at least one risk factor, including\nan underlying disease. It seems that Voriconazole therapy is effective among transplant patients\nwith pulmonary Aspergillosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574886318666221206102653","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T07:25:16Z","timestamp":1670397916000},"page":"61-69","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Manifestations, Prevalence, Management and Outcome of Invasive Aspergillosis\nin Post-Liver Transplant Patients"],"prefix":"10.2174","volume":"19","author":[{"given":"Mohsen","family":"Aliakbarian","sequence":"first","affiliation":[{"name":"Transplant Research Center, Clinical Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Surgical Oncology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rozita","family":"Khodashahi","sequence":"additional","affiliation":[{"name":"Fellowship in IC Host and Transplant, Clinical Research Development Unit, Imam Reza Hospital, Faculty of Medicine,\nMashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Transplant Research Center, Clinical Research Institute,\nMashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Department of Infectious Diseases and Tropical Medicine,\nFaculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kambiz Akhavan","family":"Rezayat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and\nHepatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Reza","family":"Naderi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Tropical Medicine,\nFaculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandana","family":"Khodashahi","sequence":"additional","affiliation":[{"name":"Rheumatic Diseases Research\nCenter, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maziar Mortazavi","family":"Pasand","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Tropical Medicine,\nFaculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebrahim","family":"Khaleghi","sequence":"additional","affiliation":[{"name":"Organ Procurement and Transplant Center of Mashhad\nUniversity of Medical Sciences, Montasryieh Hospital, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maliheh Dadgar","family":"Moghaddam","sequence":"additional","affiliation":[{"name":"Community Medical Department, Faculty of\nMedicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1186\/s12879-018-3527-5","volume":"18","author":"A\u00eft-Ammar N.","year":"2018","unstructured":"A\u00eft-Ammar N.; Levesque E.; Murat J.B.; Aspergillus pseudodeflectus: A new human pathogen in liver transplant patients. 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