{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:45:34Z","timestamp":1778240734317,"version":"3.51.4"},"reference-count":22,"publisher":"Bentham Science Publishers Ltd.","issue":"3","funder":[{"DOI":"10.13039\/501100004697","name":"Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["9503251542"],"award-info":[{"award-number":["9503251542"]}],"id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["RRCT"],"published-print":{"date-parts":[[2019,8,21]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Pruritus is one of the most common and disabling symptoms of liver disease\nsuch as Primary Sclerosing Cholangitis and Primary Biliary Cholangitis. Cholestyramine, rifampin,\nopioid antagonists, antihistaminic agents and SSRIs are used for the management of pruritus. Due to\nrifampin drug interactions as well as its serious side effects such as hepatotoxicity, clinicians are endeavoruing\nto find a safer and a more effective substitution.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The purpose of this study was to compare the efficacy and safety of sertraline with rifampin\nin the management of cholestatic pruritus.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>In a single-blinded randomized clinical trial a total of 36 patients of PSC and PBC were\ndivided into two equal groups, one group received 100 mg\/day sertraline and the other group received\nrifampin 300 mg\/day for 4 weeks. Visual analog scale was used to record pruritus severity at\nbaseline and 4 weeks after drug intervention, also, ALT, AST, ALP and total bilirubin of all patients\nwere measured at three different time points.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Over the follow-up period, pruritus had relieved in both groups, but there was no significant\ndifferences between sertraline and rifampin in pruritus management (pvalue=0.740), also there was no\nsignificant difference between the two intervention strategies (A versus B) in total bilirubin level\n(pvalue=0.106). Moreover, the ALT, AST and ALP levels were found to be significantly different between\nthe two groups (Pvalue\u02c20.01).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>There is no difference between sertraline and rifampin in pruritus improvement, but sertraline\nhas less adverse effects on hepatobiliary enzyme levels, so it seems to be safer than rifampin.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574887114666190328130720","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T12:48:22Z","timestamp":1566391702000},"page":"217-223","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of Sertraline with Rifampin in the treatment of Cholestatic Pruritus: A Randomized Clinical Trial"],"prefix":"10.2174","volume":"14","author":[{"given":"Sara","family":"Ataei","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Kord","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Larki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Yasrebifar","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Mehrpooya","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Seyedtabib","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Hasanzarrini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1159\/000360518","volume":"32","author":"Kremer A.E.","year":"2014","unstructured":"Kremer A.E.; Bolier R.; van Dijk R.; Elferink R.P.O.; Beuers U.; Advances in pathogenesis and management of pruritus in cholestasis. Digestiv Dis 2014,32(5),637-645","journal-title":"Digestiv Dis"},{"key":"ref=2","first-page":"158","volume":"11","author":"Huesmann M.","year":"2013","unstructured":"Huesmann M.; Huesmann T.; Osada N.; Phan N.Q.; Kremer A.E.; St\u00e4nder S.; Cholestatic pruritus: A retrospective analysis on clinical characteristics and treatment response. J Dtsch Dermatol Ges 2013,11(2),158-168","journal-title":"J Dtsch Dermatol Ges"},{"key":"ref=3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1046\/j.1365-2036.2003.01458.x","volume":"17","author":"Mela M.","year":"2003","unstructured":"Mela M.; Mancuso A.; Burroughs A.; Pruritus in cholestatic and other liver diseases. Aliment Pharmacol Ther 2003,17(7),857-870","journal-title":"Aliment Pharmacol Ther"},{"key":"ref=4","first-page":"153","author":"Metze D.","year":"2001","unstructured":"Metze D.; Luger T.;  Nervous system in the skin The biology of the skin 2001,153-176","journal-title":"Nervous system in the skin The biology of the skin"},{"key":"ref=5","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.3748\/wjg.v21.i5.1404","volume":"21","author":"Bassari R.","year":"2015","unstructured":"Bassari R.; Koea J.B.; Jaundice associated pruritis: A review of pathophysiology and treatment. World J Gastroenterol 2015,21(5),1404","journal-title":"World J Gastroenterol"},{"key":"ref=6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/hep.26909","volume":"60","author":"Beuers U.","year":"2014","unstructured":"Beuers U.; Kremer A.E.; Bolier R.; Elferink R.P.O.; Pruritus in cholestasis: facts and fiction. Hepatology 2014,60(1),399-407","journal-title":"Hepatology"},{"key":"ref=7","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1111\/j.1572-0241.2003.08662.x","volume":"98","author":"Browning J.","year":"2003","unstructured":"Browning J.; Combes B.; Mayo M.J.; Long-term efficacy of sertraline as a treatment for cholestatic pruritus in patients with primary biliary cirrhosis. Am J Gastroenterol 2003,98(12),2736","journal-title":"Am J Gastroenterol"},{"key":"ref=8","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1440-1746.2012.07109.x","volume":"27","author":"Imam M.H.","year":"2012","unstructured":"Imam M.H.; Gossard A.A.; Sinakos E.; Lindor K.D.; Pathogenesis and management of pruritus in cholestatic liver disease. J Gastroenterol Hepatol 2012,27(7),1150-1158","journal-title":"J Gastroenterol Hepatol"},{"key":"ref=9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2340\/00015555-1265","volume":"92","author":"Reich A.","year":"2012","unstructured":"Reich A.; Heisig M.; Phan N.Q.; Visual analogue scale: Evaluation of the instrument for the assessment of pruritus. Acta Dermato-venereol 2012,92(5),497-501","journal-title":"Acta Dermato-venereol"},{"key":"ref=10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2165\/00003088-197803020-00002","volume":"3","author":"Acocella G.","year":"1978","unstructured":"Acocella G.; Clinical pharmacokinetics of rifampicin. Clin Pharmacokinet 1978,3(2),108-127","journal-title":"Clin Pharmacokinet"},{"key":"ref=11","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.2165\/00003088-200241150-00002","volume":"41","author":"De Vane C.L.","year":"2002","unstructured":"De Vane C.L.; Liston H.L.; Markowitz J.S.; Clinical pharmacokinetics of sertraline. Clin Pharmacokinet 2002,41(15),1247-1266","journal-title":"Clin Pharmacokinet"},{"key":"ref=12","first-page":"5","volume":"2015","author":"Amidi N.","year":"2015","unstructured":"Amidi N.; Moradkhani S.; Sedaghat M.; Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function. J Herb Med Pharmacol 2015,2015,5","journal-title":"J Herb Med Pharmacol"},{"key":"ref=13","first-page":"199","volume":"23","author":"Jessurun J.","year":"2018","unstructured":"Jessurun J.; Histopathologic approach to cholestatic diseases of the liver. AJSP Rev Rep 2018,23(5),199-213","journal-title":"AJSP Rev Rep"},{"key":"ref=14","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/978-3-319-33919-1_61","author":"Weber M.B.","year":"2018","unstructured":"Weber M.B.; Camozzato F.O.;  Pruritus Dermatology in public health environments 2018,1279-1298","journal-title":"Pruritus Dermatology in public health environments"},{"key":"ref=15","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1517\/14656566.2010.484420","volume":"11","author":"Patel T.","year":"2010","unstructured":"Patel T.; Yosipovitch G.; Therapy of pruritus. Expert Opin Pharmacother 2010,11(10),1673-1682","journal-title":"Expert Opin Pharmacother"},{"key":"ref=16","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0190-9622(95)91818-3","volume":"33","author":"Connolly C.S.","year":"1995","unstructured":"Connolly C.S.; Kantor G.R.; Menduke H.; Hepatobiliary pruritus: What are effective treatments? J Am Acad Dermatol 1995,33(5),801-805","journal-title":"J Am Acad Dermatol"},{"key":"ref=17","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/hep.21553","volume":"45","author":"Mayo M.J.","year":"2007","unstructured":"Mayo M.J.; Handem I.; Saldana S.; Sertraline as a first\u2010line treatment for cholestatic pruritus. Hepatology 2007,45(3),666-674","journal-title":"Hepatology"},{"key":"ref=18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/MPG.0000000000001385","volume":"64","author":"Th\u00e9baut A.","year":"2017","unstructured":"Th\u00e9baut A.; Habes D.; Gottrand F.; Sertraline as an additional treatment for cholestatic pruritus in children. J Pediatr Gastroenterol Nutr 2017,64(3),431-435","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref=19","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0140-6736(89)91608-5","volume":"333","author":"Bachs L.","year":"1989","unstructured":"Bachs L.; Elena M.; Par\u00e9s A.; Piera C.; Rod\u00e9s J.; Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis. Lancet 1989,333(8638),574-576","journal-title":"Lancet"},{"key":"ref=20","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/j.1572-0241.2007.01200.x","volume":"102","author":"Tandon P.","year":"2007","unstructured":"Tandon P.; Rowe B.H.; Vandermeer B.; Bain V.G.; The efficacy and safety of bile Acid binding agents, opioid antagonists, or rifampin in the treatment of cholestasis-associated pruritus. Am J Gastroenterol 2007,102(7),1528","journal-title":"Am J Gastroenterol"},{"key":"ref=21","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/gut.50.3.436","volume":"50","author":"Prince M.","year":"2002","unstructured":"Prince M.; Burt A.; Jones D.; Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis. Gut 2002,50(3),436-439","journal-title":"Gut"},{"key":"ref=22","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10620-008-0524-3","volume":"54","author":"Tabak F.","year":"2009","unstructured":"Tabak F.; Gunduz F.; Tahan V.; Tabak O.; Ozaras R.; Sertraline hepatotoxicity: Report of a case and review of the literature. Dig Dis Sci 2009,54(7),1589-1591","journal-title":"Dig Dis Sci"}],"container-title":["Reviews on Recent Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/171065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T08:36:11Z","timestamp":1574670971000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/171065\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,8,21]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574887114666190328130720","relation":{},"ISSN":["1574-8871"],"issn-type":[{"value":"1574-8871","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8,21]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}