{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:24:29Z","timestamp":1747207469451,"version":"3.40.5"},"reference-count":41,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["RRCT"],"published-print":{"date-parts":[[2021,1,12]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Hereditary hemorrhagic telangiectasia (HHT, or Rendu-Osler-Weber disease)\nis a rare inherited syndrome, characterized by artero-venous malformations (AVMs or telangiectasia)\nwith autosomal dominant transmission. AVMs can occur in any organ of the body but\nmost commonly it occurs in the nose, pulmonary, hepatic and cerebral circulations. In patients with\nHHT, we report teleangectasia of mucosa of the gastrointestinal tract.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Research and online content related to HHT online activity is reviewed, and DOC writing\nexcerpts are used to illustrate key themes.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> Patients with HHT have a high rate of complications related to bleeding; of them gastrointestinal\nbleeding accounts for 10.8%. Several therapies, both medical and endoscopic, were utilized\nto reduce the need for transfusions and hospitalization.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>A combination of medical and endoscopic therapy is probably the best option.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574887115666200603160033","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T05:13:36Z","timestamp":1591247616000},"page":"321-327","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Management of Gastrointestinal Bleeding in Rendu-Osler Disease"],"prefix":"10.2174","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0406-4290","authenticated-orcid":true,"given":"Annalisa","family":"Tortora","sequence":"first","affiliation":[{"name":"Department of Gastroenterological, Fondazione Policlinico Gemelli IRCCS, Endocrino-Metabolic, and Nefro-urological Science, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clelia","family":"Marmo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological, Fondazione Policlinico Gemelli IRCCS, Endocrino-Metabolic, and Nefro-urological Science, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Gasbarrini","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological, Fondazione Policlinico Gemelli IRCCS, Endocrino-Metabolic, and Nefro-urological Science, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Costamagna","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological, Fondazione Policlinico Gemelli IRCCS, Endocrino-Metabolic, and Nefro-urological Science, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Riccioni","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological, Fondazione Policlinico Gemelli IRCCS, Endocrino-Metabolic, and Nefro-urological Science, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s13023-019-1107-4","volume":"14","author":"Tortora A.","year":"2019","unstructured":"Tortora A.; Riccioni M.E.; Gaetani E.; Ojetti V.; Holleran G.; Gasbarrini A.; Rendu-Osler-Weber disease: A gastroenterologist\u2019s perspective Orphanet J Rare Dis 2019,14,130","journal-title":"Orphanet J Rare Dis"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1056\/NEJM199510053331407","volume":"333","author":"Guttmacher A.E.","year":"1995","unstructured":"Guttmacher A.E.; Marchuk D.A.; White R.I.; Hereditary hemorrhagic telangiectasia. 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