{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:24:32Z","timestamp":1747207472337,"version":"3.40.5"},"reference-count":29,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["RRCT"],"published-print":{"date-parts":[[2021,5,7]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Although epidemic, novel coronavirus (SARS-CoV-2) infection rarely affects pediatric\npopulation. However, in the last months an increasing number of Italian pediatricians has reported the occurrence of\nerythema pernio-like in children following a flu-like syndrome, after the outbreak of SARS-CoV-2 infection.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p> To report cutaneous manifestation of SARS-CoV-2 infection in 4 adolescents.\n<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Observational study reporting 4 adolescents with skin lesions, 2 weeks after the occurrence of a flu-like\nsyndrome.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Fourteen days after a flu-like syndrome, adolescents exhibited skin lesions to toes and\nfeet. These lesions were rounded, with blurred limits, with a 5-15 mm diameter, red-violaceous-\nbluish colored, sometimes resulting in bullous lesions in correspondence of the central or apical\nportion, which tended to be covered with blackish crusts after evolution. Lesions were also accompanied\nby pain of variable intensity and evolved within two or three weeks to self-resolution\nwithout particular sequelae. In two patients, pharyngeal and nasal swabs were negative for SARSCoV-\n2 infection, at the presentation of skin lesions. After 2 months from clinical manifestations,\npatients were tested positive for SARS-CoV-2 antibodies.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>In pediatric and adolescent population, the occurrence of an erythema pernio-like after a flu-like syndrome\ncould be associated to SARS-CoV-2 infection. \n<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574887115666201016153031","type":"journal-article","created":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T04:53:11Z","timestamp":1602996791000},"page":"216-219","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Erythema Pernio-Like in Four Adolescents in the Era of the Coronavirus-2 Infection"],"prefix":"10.2174","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0981-9939","authenticated-orcid":true,"given":"Luigi","family":"Promenzio","sequence":"first","affiliation":[{"name":"Pediatric Orthopedy, Department Villa Serena for Children, Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-1281","authenticated-orcid":true,"given":"Fabio","family":"Arcangeli","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Pediatric Dermatology, \u201cGuglielmo Marconi\u201d University, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8246-7143","authenticated-orcid":true,"given":"Elisabetta","family":"Cortis","sequence":"additional","affiliation":[{"name":"Pediatric Rheumathology, Sant'Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-6302","authenticated-orcid":true,"given":"Elisa","family":"Sama","sequence":"additional","affiliation":[{"name":"Department of Dermatology, M. 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