{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:09:10Z","timestamp":1785150550124,"version":"3.55.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"8","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CSCR"],"published-print":{"date-parts":[[2020,11,10]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Substantial evidences support the hypothesis that the epicardium has a role in\ncardiac repair and regeneration in part providing, by epithelial to mesenchymal transition (EMT), progenitor\ncells that differentiate into cardiac cell types and in part releasing paracrine factors that contribute\nto cardiac repair. Besides cell contribution, a significant paracrine communication occurs between\nthe epicardium and the myocardium that improves the whole regenerative response. Signaling pathways\nunderlying this communication are multiple as well as soluble factors involved in cardiac repair\nand secreted both by myocardial and epicardial cells. Most recently, extracellular vesicles, i.e.\nexosomes, that accumulate in the pericardial fluid (PF) and are able to transport bioactive molecules\n(cytosolic proteins, mRNAs, miRNAs and other non-coding RNAs), have been also identified as potential\nmediators of epicardial-mediated repair following myocardial injury.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>This mini-review provides an overview of the epicardial-myocardial signaling in regulating\ncardiac repair in ischemic heart diseases. Indeed, a detailed understanding of the crosstalk between\nmyocardial and epicardial cells and how paracrine mechanisms are involved in the context of ischemic\nheart diseases would be of tremendous help in developing novel therapeutic approaches to promote\ncardiomyocytes survival and heart regeneration following myocardial infarction (MI).<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574888x15666200219105448","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T13:16:45Z","timestamp":1582118205000},"page":"661-673","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cardiac Repair: The Intricate Crosstalk between the Epicardium and the Myocardium"],"prefix":"10.2174","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8833-2987","authenticated-orcid":true,"given":"Laura","family":"Pellegrini","sequence":"first","affiliation":[{"name":"Institute of Oncology Research (IOR), Bellinzona, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Foglio","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pontemezzo","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Germani","sequence":"additional","affiliation":[{"name":"Laboratory of Vascular Pathology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Fondazione Luigi Maria Monti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5847-6015","authenticated-orcid":true,"given":"Matteo Antonio","family":"Russo","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Pisana and MEBIC Consortium, San Raffaele Open University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-9628","authenticated-orcid":true,"given":"Federica","family":"Limana","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Pathology, IRCCS San Raffaele Pisana, Rome and San Raffaele Open University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/179530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/179530\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/179530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T19:28:52Z","timestamp":1621538932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/179530\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,11,10]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574888x15666200219105448","relation":{},"ISSN":["1574-888X"],"issn-type":[{"value":"1574-888X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,10]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}