{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:19:51Z","timestamp":1788851991687,"version":"build-2803163510"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"8","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["RC2019"],"award-info":[{"award-number":["RC2019"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CSCR"],"published-print":{"date-parts":[[2020,11,10]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Nowadays, cardiac regeneration is an emerging topic in the cardiovascular field because of\nthe compelling need for effective therapies for repairing or replacing cardiac tissue damaged by pathological\nor physiological conditions. Indeed, irreversible myocardial remodeling which follows acute\nmyocardial infarction represents a serious burden of this century. In this context, a great improvement\nin pharmacological and interventional techniques is accompanied by a big challenge of cardiac regenerative\nmedicine. In the last 20 years, several clinical trials tried to investigate the role of different\ntypes of stem cells in promoting cardiac repair. However, the promising results obtained in the preclinical\ntrials have not yet been reproduced in patients. Thus, the development of novel strategies to\nimprove stem cell efficiency became imperative. Here, an overview of the more recent cell types proposed\nfor cardiac regeneration is presented, together with the most interesting approaches to enhance\ncell regenerative potential as well as cell-free approaches.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574888x15666200225124451","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T14:47:56Z","timestamp":1582642076000},"page":"696-710","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["New Strategies to Enhance Myocardial Regeneration: Expectations and Challenges from Preclinical Evidence"],"prefix":"10.2174","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7291-5811","authenticated-orcid":true,"given":"Erica","family":"Rurali","sequence":"first","affiliation":[{"name":"Vascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6323-147X","authenticated-orcid":true,"given":"Maria Cristina","family":"Vinci","sequence":"additional","affiliation":[{"name":"Vascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-9203","authenticated-orcid":true,"given":"Beatrice","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Vascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1885-7470","authenticated-orcid":true,"given":"Veronica","family":"Barbagallo","sequence":"additional","affiliation":[{"name":"Vascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-5735","authenticated-orcid":true,"given":"Giulio","family":"Pompilio","sequence":"additional","affiliation":[{"name":"Vascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8859-8259","authenticated-orcid":true,"given":"Elisa","family":"Gambini","sequence":"additional","affiliation":[{"name":"Vascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino IRCCS, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/179728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/179728\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/179728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T19:28:56Z","timestamp":1621538936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/179728\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,11,10]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574888x15666200225124451","relation":{},"ISSN":["1574-888X"],"issn-type":[{"value":"1574-888X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,10]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}