{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:56:09Z","timestamp":1792641369805,"version":"4.5.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"4","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401591"],"award-info":[{"award-number":["81401591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772069"],"award-info":[{"award-number":["81772069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801911"],"award-info":[{"award-number":["81801911"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National key research and development project","doi-asserted-by":"publisher","award":["2016YFC1100803"],"award-info":[{"award-number":["2016YFC1100803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CSCR"],"published-print":{"date-parts":[[2021,6,8]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Diseases, trauma, and injuries are highly prevalent conditions that lead to many critical\ntissue defects. Tissue engineering has great potentials to develop functional scaffolds that mimic natural\ntissue structures to improve or replace biological functions. In many kinds of technologies,\nelectrospinning has received widespread attention for its outstanding functions, which is capable of\nproducing nanofibre structures similar to the natural extracellular matrix. Amongst the available\nbiopolymers for electrospinning, poly (caprolactone) (PCL) has shown favorable outcomes for tissue\nregeneration applications. According to the characteristics of different tissues, PCL can be modified\nby altering the functional groups or combining with other materials, such as synthetic polymers,\nnatural polymers, and metal materials, to improve its physicochemical, mechanical, and biological\nproperties, making the electrospun scaffolds meet the requirements of different tissue engineering\nand regenerative medicine. Moreover, efforts have been made to modify nanofibres with\nseveral bioactive substances to provide cells with the necessary chemical cues and a more in vivo\nlike environment. In this review, some recent developments in both the design and utility of electrospun\nPCL-based scaffolds in the fields of bone, cartilage, skin, tendon, ligament, and nerve are\nhighlighted, along with their potential impact on future research and clinical applications.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574888x15666201014145703","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T06:27:29Z","timestamp":1602743249000},"page":"414-442","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Applications of Poly(caprolactone)-based Nanofibre Electrospun Scaffolds in Tissue Engineering and Regenerative Medicine"],"prefix":"10.2174","volume":"16","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghua","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangang","family":"You","sequence":"additional","affiliation":[{"name":"Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Burns & Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/186880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/186880\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/186880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T15:48:56Z","timestamp":1627400936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/186880\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,6,8]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574888x15666201014145703","relation":{},"ISSN":["1574-888X"],"issn-type":[{"value":"1574-888X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,8]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}