{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:31:14Z","timestamp":1784287874859,"version":"3.55.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"7","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CSCR"],"published-print":{"date-parts":[[2021,9,3]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Mesenchymal stem cells (MSCs) have shown promising therapeutic effects in a wide variety\nof medical conditions, including neurodegenerative disorders and cardiovascular diseases. Although\npreliminary research has emphasized the ability of MSCs to engraft at sites of injury, several\nstudies have revealed that MSCs mediate their effects through the release of various paracrine\nfactors and through their antioxidant, anti-inflammatory, immunomodulatory, and anti-apoptotic effects.\nThe clinical implications of MSCs application are limited due to their low survival rate in\nconditions of inflammation, oxidative stress, and nutrient restriction in damaged areas. Furthermore,\nthe function of isolated MSCs is usually affected by the patient\u2019s health. Therefore, it is necessary\nto develop new methods to enhance the therapeutic efficacy of MSCs under pathophysiological\nconditions. This review provides an overview of the general properties of MSCs, their therapeutic\npotential in neurodegenerative disorders such as Alzheimer\u2019s disease, Parkinson\u2019s disease,\nmultiple sclerosis, amyotrophic lateral sclerosis, and Huntington\u2019s disease, as well as cardiovascular\ndiseases such as myocardial infarction, diabetic cardiomyopathy, and dilated cardiomyopathy,\nand their related mechanisms. In addition, this review also discusses potential problems and side effects,\nas well as current and future directions for improvement of MSCs therapy and their implications\nand applications.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574888x16666210303151237","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T13:58:48Z","timestamp":1614779928000},"page":"858-876","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Directions for Enhancement of the Therapeutic Efficacy of Mesenchymal Stem Cells in Different Neurodegenerative and Cardiovascular Diseases: Current Status and Future Perspectives"],"prefix":"10.2174","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-2815","authenticated-orcid":true,"given":"Lamiaa A.","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled F.","family":"Al-Massri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, Faculty of Medicine and Health Sciences, University of Palestine, Gaza, Palestinian Territory, Occupied"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Stem Cell Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/192039","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/192039\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/192039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T18:08:51Z","timestamp":1630951731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/192039\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,3]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,9,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574888x16666210303151237","relation":{},"ISSN":["1574-888X"],"issn-type":[{"value":"1574-888X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}