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These cells exhibit stem\ncell properties, strong potential for self-renewal, and show multi-lineage differentiation, and they have\ntherefore been widely employed in stem cell therapy, tissue regeneration, and inflammatory diseases.\nAmong them, stem cells from human exfoliated deciduous teeth [SHED] and their derivatives have\nmanifested wide application in the treatment of diseases because of their outstanding advantages\u2014\nincluding convenient access, easy storage, and less immune rejection. Numerous studies have shown that\nmost diseases are closely associated with inflammation and that inflammatory diseases are extremely\ndestructive, can lead to necrosis of organ parenchymal cells, and can deposit excessive extracellular matrix\nin the tissues. Inflammatory diseases are thus the principal causes of disability and death from many\ndiseases worldwide. SHED and their derivatives not only exhibit the basic characteristics of stem cells but\nalso exhibit some special properties of their own, particularly with regard to their great potential in inhibiting\ninflammation and tissue regeneration. SHED therapy may provide a new direction for the treatment\nof inflammation and corresponding tissue defects. In this review, we critically analyze and summarize the\nlatest findings on the behaviors and functions of SHED, serum\u2011free conditioned medium from SHED\n[SHED-CM], and extracellular vesicles, especially exosomes, from SHED [SHED-Exos], and discuss\ntheir roles and underlying mechanisms in the control of inflammatory diseases, thus further highlighting\nadditional functions for SHED and their derivatives in future therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1574888x17666220417153309","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T03:29:03Z","timestamp":1650425343000},"page":"302-316","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of Mesenchymal Stem Cells from Human Exfoliated Deciduous\nTeeth and their Derivatives in Inflammatory Diseases Therapy"],"prefix":"10.2174","volume":"17","author":[{"given":"Junxiang","family":"Su","sequence":"first","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology &amp; Shanxi Province Key Laboratory of Oral Diseases\nPrevention and New Materials, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Ge","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology &amp; Shanxi Province Key Laboratory of Oral Diseases\nPrevention and New Materials, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Peking University School and Hospital of\nStomatology &amp; National Engineering Laboratory for Digital and Material Technology of Stomatology &amp; Beijing Key\nLaboratory of Digital Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology &amp; Shanxi Province Key Laboratory of Oral Diseases\nPrevention and New Materials, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanxi Medical University School and Hospital of Stomatology &amp; Shanxi Province Key Laboratory of Oral Diseases\nPrevention and New Materials, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1242\/dev.134189","volume":"143","author":"Sharpe P.T.","year":"2016","unstructured":"Sharpe P.T.; Dental mesenchymal stem cells. 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