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AD's previously known pathological basis is the deposition of amyloid \u03b2 (A\u03b2) aggregates\nand the formation of neurofibrillary tangles by tau hyperphosphorylation in the cell bodies of neurons that\nare located in the hippocampus, neocortex, and certain other regions of the cerebral hemispheres and limbic\nsystem. The lack of neurotransmitter acetylcholine and the activation of oxidative stress cascade may\nalso contribute to the pathogenesis of AD. These pathological events can lead to irreversible loss of neuronal\nnetworks and the emergence of memory impairment and cognitive dysfunction that can engender an\nabnormal change in the personality. AD cannot be cured, and to some extent, the prescribed medications\ncan only manage the symptoms associated with this disease. Several studies have reported that the regenerative\nabilities of neural stem\/progenitor cells (NSCs) remarkably decline in AD, which disturbs the\nbalancing power to control its progression. Exogenous infusion or endogenous activation of NSCs may be\nthe ultimate solution to restore the neuronal networks in the brain of AD patients and regenerate the damaged\nareas responsible for memory and cognition. In this mini-review, we will touch upon the fate of\nNSCs in AD and the utilization of neurogenesis using modified NSCs to restore cognitive functions in\nAD.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574888x17666220831105257","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T16:20:55Z","timestamp":1661962855000},"page":"580-594","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Molecular and Functional Changes of Neural Stem Cells in Alzheimer\u2019s\nDisease: Can They be Reinvigorated to Conduct Neurogenesis"],"prefix":"10.2174","volume":"18","author":[{"given":"Ejlal","family":"Abu-El-Rub","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramada R.","family":"Khasawneh","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatimah A.","family":"Almahasneh","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basma Milad","family":"Aloud","sequence":"additional","affiliation":[{"name":"Department of Physiology\nand Pathophysiology, University of Manitoba, Winnipeg, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana M.","family":"Zegallai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Therapeutics,\nUniversity of Manitoba, Winnipeg, Canada"},{"name":"DREAM, Children\u2019s Hospital Research Institute of Manitoba, Winnipeg,\nMB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","volume":"14","author":"DeTure M.A.","year":"2019","unstructured":"DeTure M.A.; Dickson D.W.; The neuropathological diagnosis of Alzheimer\u2019s disease. 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