{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:53:08Z","timestamp":1785477188684,"version":"3.56.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PRI"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>In spite of the protean nature of the disease, inflammation is a hallmark of brucellosis and affected tissues usually\nexhibit inflammatory infiltrates. As Brucella lacks exotoxins, exoproteases or cytolysins, pathological findings in\nbrucellosis probably arise from inflammation-driven processes. The cellular and molecular bases of immunopathological\nphenomena probably involved in Brucella pathogenesis have been unraveled in the last few years. Brucella-infected osteoblasts,\neither alone or in synergy with infected macrophages, produce cytokines, chemokines and matrixmetalloproteinases\n(MMPs), and similar phenomena are mounted by fibroblast-like synoviocytes. The released cytokines\npromote the secretion of MMPs and induce osteoclastogenesis. Altogether, these phenomena may contribute to the bone\nloss and cartilage degradation usually observed in brucellar arthritis and osteomyelitis. Proinflammatory cytokines may be\nalso involved in the pathogenesis of neurobrucellosis. B. abortus and its lipoproteins elicit an inflammatory response in\nthe CNS of mice, leading to astrogliosis, a characteristic feature of neurobrucellosis. Heat-killed bacteria (HKBA) and the\nL-Omp19 lipoprotein elicit astrocyte apoptosis and proliferation (two features of astrogliosis), and apoptosis depends on\nTNF-&amp;#945; signaling. Brucella also infects and replicates in human endothelial cells, inducing the production of chemokines\nand IL-6, and an increased expression of adhesion molecules. The sustained inflammatory process derived from the longlasting\ninfection of the endothelium may be important for the development of endocarditis. Therefore, while Brucella induces\na low grade inflammation as compared to other pathogens, its prolonged intracellular persistence in infected tissues\nsupports a long-lasting inflammatory response that mediates different pathways of tissue damage. In this context, approaches\nto avoid the invasion of host cells or limit the intracellular survival of the bacterium may be suitable to prevent\nthe pathological consequences of Brucella infections. The article presents some of the recent patents related to such approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1574891x11308010005","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T09:28:55Z","timestamp":1367918935000},"page":"18-26","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Immunopathology of Brucella Infection"],"prefix":"10.2174","volume":"8","author":[{"given":"Pablo","family":"C. Baldi","sequence":"first","affiliation":[{"name":"IDEHU, Facultad de Farmacia y Bioquimica UBA, Junin 956, 1113-Buenos Aires, Argentina.,Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"H. Giambartolomei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Recent Patents on Anti-Infective Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1574891X11308010005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/107314\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1574891X11308010005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:51:49Z","timestamp":1761389509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/107314\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574891x11308010005","relation":{},"ISSN":["1574-891X"],"issn-type":[{"value":"1574-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}