{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:31:09Z","timestamp":1792171869575,"version":"4.4.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PRI"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Herpes simplex virus (HSV) infections can be treated efficiently by the application of antiviral drugs. The herpes\nfamily of viruses is responsible for causing a wide variety of diseases in humans. The standard therapy for the management\nof such infections includes acyclovir (ACV) and penciclovir (PCV) with their respective prodrugs valaciclovir\nand famciclovir. Though effective, long term prophylaxis with the current drugs leads to development of drug-resistant viral\nisolates, particularly in immunocompromised patients. Moreover, some drugs are associated with dose-limiting toxicities\nwhich limit their further utility. Therefore, there is a need to develop new antiherpetic compounds with different\nmechanisms of action which will be safe and effective against emerging drug resistant viral isolates. Significant advances\nhave been made towards the design and development of novel antiviral therapeutics during the last decade. As evident by\ntheir excellent antiviral activities, pharmaceutical companies are moving forward with several new compounds into various\nphases of clinical trials. This review provides an overview of structure and life cycle of HSV, progress in the development\nof new therapies, update on the advances in emerging therapeutics under clinical development and related recent\npatents for the treatment of Herpes simplex virus infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1574891x11308010011","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T09:28:55Z","timestamp":1367918935000},"page":"55-67","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Update On Emerging Antivirals For The Management Of Herpes Simplex Virus Infections: A Patenting Perspective"],"prefix":"10.2174","volume":"8","author":[{"given":"Aswani","family":"D. Vadlapudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"K. Vadlapatla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashim","family":"K. Mitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Recent Patents on Anti-Infective Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1574891X11308010011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/107320\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1574891X11308010011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:51:51Z","timestamp":1761389511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/107320\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574891x11308010011","relation":{},"ISSN":["1574-891X"],"issn-type":[{"value":"1574-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}