{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:57:14Z","timestamp":1790045834988,"version":"4.0.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PRI"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Quorum sensing (QS) is a bacterial communication process that depends on the bacterial population density. It\ninvolves small diffusible signaling molecules which activate the expression of myriad genes that control diverse array of\nfunctions like bioluminescence, virulence, biofilm formation, sporulation, to name a few. Since QS is responsible for virulence\nin the clinically relevant bacteria, inhibition of QS appears to be a promising strategy to control these pathogenic\nbacteria. With indiscriminate use of antibiotics, there has been an alarming increase in the number of antibiotic resistant\npathogens. Antibiotics are no longer the magic bullets they were once thought to be and therefore there is a need for\ndevelopment of new antibiotics and\/or other novel strategies to combat the infections caused by multidrug resistant organisms.\nQuorum sensing inhibition or quorum quenching has been pursued as one of such novel strategies. While antibiotics\nkill or slow down the growth of bacteria, quorum sensing inhibitors (QSIs) or quorum quenchers (QQs) attenuate bacterial\nvirulence. A large body of work on QS has been carried out in deadly pathogens like Pseudomonas aeruginosa,\nStaphylococcus aureus, Vibrio fischeri, V. harveyi, Escherichia coli and V. cholerae etc to unravel the mechanisms of QS\nas well as identify and study QSIs. This review describes various aspects of QS, QSI, different model systems to study\nthese phenomena and recent patents on various QSIs. It suggests QSIs as attractive alternatives for controlling human,\nanimal and plant pathogens and their utility in agriculture and other industries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1574891x11308010012","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T09:28:55Z","timestamp":1367918935000},"page":"68-83","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":156,"title":["Bacterial Quorum Sensing Inhibitors: Attractive Alternatives for Control of Infectious Pathogens Showing Multiple Drug Resistance"],"prefix":"10.2174","volume":"8","author":[{"given":"Ashima","family":"K. Bhardwaj","sequence":"first","affiliation":[{"name":"Department of Human Health and Diseases, Indian Institute of Advanced Research, Koba Institutional Area, Gandhinagar 382 007, Gujarat, India.,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kittappa","family":"Vinothkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Rajpara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Recent Patents on Anti-Infective Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1574891X11308010012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/107321\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1574891X11308010012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:51:51Z","timestamp":1761389511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/107321\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574891x11308010012","relation":{},"ISSN":["1574-891X"],"issn-type":[{"value":"1574-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}