{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:57:38Z","timestamp":1761389858150,"version":"build-2065373602"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PRI"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Drug combinations (DCs) have been successfully used in different kinds of diseases such as cancer, AIDS,\nmalaria, infectious diseases, asthma, diarrhea, hypertension, neurological disorders, among others. In this context, an\nimportant concept in drug discovery relates to the fixed-dose combinations (FDC), which can be defined as a formulation\nof two or more biologically active substances, combined in a single drug, and available at certain fixed doses. FDC\npresents several advantages, such as reduced risks of emergence of drug resistant strains, improvement of patient compliance,\nreduced costs of treatment and a simplified drug supply management, shipping and distribution. Due to the importance of\nDCs in drug discovery, the purpose of this review is to highlight the importance of this strategy for tuberculosis treatment\nand also for studies of new promising drug combinations to be used against this disease, specially focused on resistant\nbacterial strains. Relevant patents concerning combined treatment of tuberculosis are analyzed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1574891x113089990001","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T12:59:36Z","timestamp":1375361976000},"page":"130-138","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Relevance of New Drug Combinations for Modern Tuberculosis Treatment - A Patent Perspective"],"prefix":"10.2174","volume":"8","author":[{"given":"Alessandra C.","family":"Pinheiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus V. N. de","family":"Souza","sequence":"additional","affiliation":[{"name":"FioCruz - Fundacao Oswaldo Cruz, Instituto de Tecnologia em Farmacos \u2013 Far Manguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 Rio de Janeiro, RJ, Brazil.,Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Recent Patents on Anti-Infective Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1574891X113089990001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/113692\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1574891X113089990001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:51:47Z","timestamp":1761389507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/113692\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574891x113089990001","relation":{},"ISSN":["1574-891X"],"issn-type":[{"type":"print","value":"1574-891X"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}