{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:16:44Z","timestamp":1768875404927,"version":"3.49.0"},"reference-count":31,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PRA"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n<jats:title>Introduction:<\/jats:title>\n<jats:p>This study aimed to explore the expression profiles of fatty acid metabolism-\nrelated genes (FAMRGs) in patients with bladder cancer (BLCA).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The corresponding clinicopathological features of BLCA patients and RNA sequencing\ndata were downloaded from TCGA and GSE13507. Univariate Cox regression was used to determine\nthe prognostic value of FRGS in BLCA patients. LASSO regression analysis was then performed\nto select potential risk genes and eliminate genes that might overfit the model. Based on\nthe independent prognostication-related FRGs, the nomogram survival model was established using\nthe root mean square value of the R packet to predict the 1-year, 3-year, and 5-year survival\nrates of BLCA patients. By determining the area under the curve (AUC) value, the time-dependent\nreceiver operating characteristic curve (ROC) was used to evaluate the prognostic efficiency of\nour model.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>A total of 243 DEFRGs were identified. Twenty FRGs were found to be related to the\nprognosis of BLCA in the TCGA database. Survival curves showed that high-risk patients had\nsignificantly shorter OS than low-risk cases (p &lt; 0.001). The AUC of risk was 0.784, which was\nsuperior to age, sex, and stage, suggesting that the risk score was more favorable in predicting OS\nthan traditional pathologic prognostic factors. The AUC was 0.757 at 1 year, 0.732 at 3 years, and\n0.733 at 5 year-OS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In this study, we demonstrated that a FAMRG prognosis biomarker is associated\nwith the tumor immune microenvironment in patients with BLCA.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574892818666230516143945","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T05:20:27Z","timestamp":1684300827000},"page":"328-341","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Value of Fatty Acid Metabolism-related Genes in Patients with\nBladder Cancer"],"prefix":"10.2174","volume":"19","author":[{"given":"Qiuzheng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Urology, Wenzhou Central Hospital, Wenzhou, Zhejiang, 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Wenzhou Central Hospital, Wenzhou, Zhejiang, 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Wenzhou Central Hospital, Wenzhou, Zhejiang, 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung H.","year":"2021","unstructured":"Sung H.; Ferlay J.; Siegel R.L.; Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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