{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:47:39Z","timestamp":1791229659385,"version":"4.1.0"},"reference-count":72,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T00:00:00Z","timestamp":1371168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["clinical-practice-and-epidemiology-in-mental-health.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["CPEMH"],"published-print":{"date-parts":[[2013,6,14]]},"abstract":"<jats:p>Presenile Dementia or Early Onset Dementia (EOD) is a public health problem, it differs from Senile Dementia, and encloses a significant number of cases; nevertheless, it is still poorly understood and underdiagnosed. This study aims to review the prevalence and etiology of EOD, comparing EOD with Senile Dementia, as well as to show the main causes of EOD and their prevalence in population and non-population based studies. The computer-supported search used the following databases: Pubmed\/Medline, ISI Web of Knowledge and Scielo. The search terms were alcohol-associated dementia, Alzheimer\u2019s disease, dementia, Creutzfeldt-jakob disease, dementia with lewy bodies, early onset dementia, frontotemporal lobar degeneration, Huntington\u2019s disease, mixed dementia, neurodegenerative disorders, Parkinson\u2019s disease dementia, presenile dementia, traumatic brain injury, vascular dementia. Only papers published in English and conducted from 1985 up to 2012 were preferentially reviewed. Neurodegenerative diseases are the most common etiologies seen in EOD. Among the general population, the prevalence of EOD was found to range between 0 to 700 per 100.000 habitants in groups of 25-64 years old, with an increasing incidence with age. The progression of EOD was found to range between 8.3 to 22.8 new cases per 100.000 in those aged under 65 years. Alzheimer's disease (AD) is the major etiology, followed by Vascular Dementia (VaD) and Frontotemporal Lobar Degeneration (FTLD). A larger number of epidemiological studies to elucidate how environmental issues contribute to EOD are necessary, thus, we can collaborate in the planning and prevention of services toward dementia patients.<\/jats:p>","DOI":"10.2174\/1745017901309010088","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T02:06:50Z","timestamp":1374199610000},"page":"88-95","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":300,"title":["Epidemiology of early-onset dementia: a review of the literature"],"prefix":"10.2174","volume":"09","author":[{"given":"Renata Teles","family":"Vieira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Caixeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Cardoso","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Egidio","family":"Nardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Arias-Carri\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Giovanni","family":"Carta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s004010050452","volume":"91","author":"Giannakopoulos P","year":"1996","unstructured":"Giannakopoulos P, Hof PR, Savioz A, Guimom J, Antonarakis SE, Bouras C. \n                    Early onset dementias: clinical. neuropathological and genetics characteristics \n                     Acta Neuropathol  \n                    1996; \n                    91\n                    (5)\n                    : 451-65.","journal-title":"Acta Neuropathol"},{"key":"refR2","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/00002093-199500091-00003","volume":"9","author":"Harvey RJ","year":"1995","unstructured":"Harvey RJ, Rossor MN. \n                    Does early-onset Alzheimer disease constitute a distinct subtype? \n                    Alzheimer Dis Assoc Disord  \n                    1995; \n                    9\n                    : S7-S13.","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"refR3","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S1474-4422(10)70159-9","volume":"9","author":"Rossor MN","year":"2010","unstructured":"Rossor MN, Fox NC, Mummery CJ, Schott JM, Warren JD. \n                    The diagnosis of young-onset dementia \n                    Lancet Neurol  \n                    2010; \n                    9\n                    (8)\n                    : 793-806.","journal-title":"Lancet Neurol"},{"key":"refR4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000089546","volume":"21","author":"McMurtray A","year":"2006","unstructured":"McMurtray A, Clark DG, Christine D, Mendez MF. \n                    Early-onset dementia: frequency and causes compared to late-onset dementia \n                    Dement Geriatr Cogn Disord  \n                    2006; \n                    21\n                    : 59-64.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"refR5","first-page":"597","author":"Delaney N","year":"ers.","unstructured":"Delaney N, Rosenvinge H. \n                    Presenile dementia \n                    Suf  \n                    ers.; \n                    careers and services. 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