{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:36:53Z","timestamp":1773679013875,"version":"3.50.1"},"reference-count":35,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T00:00:00Z","timestamp":1451520000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["clinical-practice-and-epidemiology-in-mental-health.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["CPEMH"],"published-print":{"date-parts":[[2015,12,31]]},"abstract":"<jats:p><jats:italic><jats:underline>Introduction<\/jats:underline><\/jats:italic>: Aims: to measure the \nassociation between Celiac Disease (CD) and affective disorders, particularly \nBipolar Disorder (BD), since it has not been studied yet, and to measure how \nmuch the quality of life (QoL) of a person with CD is affected by comorbidity \nwith these disorders. <jats:italic><jats:underline>Methods<\/jats:underline><\/jats:italic>: Design: Case-control study. Cases: \n60 consecutive patients with CD. Controls: 240 subjects without CD, randomly \nselected after sex- and age-matching from a database of an epidemiological \nstudy. Psychiatric diagnoses according to DSM-IV carried out by physicians using \nstructured interview tools (ANTAS-SCID). QoL was measured by means of SF-12. <jats:italic>\n<jats:underline>Results<\/jats:underline><\/jats:italic>: The lifetime prevalence of Major Depressive Disorder (MDD) \nwas higher in CD than in controls (30.0% <jats:italic>vs <\/jats:italic>8.3%, P&lt;0.0001) as well as \nPanic Disorder (PD) (18.3% <jats:italic>vs <\/jats:italic>5.4%, P&lt;0.001) and BD (4.3% <jats:italic>vs <\/jats:italic>0.4%,<jats:italic> \nP&lt;0.005<\/jats:italic>). Patients with CD show a lower mean score than controls on SF12 \n(35.8\u00b15.7 <jats:italic>vs. \n<\/jats:italic>38.2\u00b16.4; p=0.010), but those without comorbidity with MDD, PD and BD do \nnot. The attributable burden of CD in worsening QoL - when comorbid with these \ndisorders - was found comparable to that of serious chronic diseases like \nWilson\u2019s Disease, and lower than Multiple Sclerosis only. <jats:italic><jats:underline>Conclusion<\/jats:underline><\/jats:italic>:<jats:bold>\n<\/jats:bold>MDD, PD and BD are strictly associated with CD. The comorbidity with these \ndisorders is the key determinant of impaired quality of life in CD. Thus a \npreventive action on mood and anxiety disorders in patients suffering from CD is \nrequired. Moreover a screening for CD in people with affective disorders and \nshowing key symptoms or family history of CD is recommended.<\/jats:p>","DOI":"10.2174\/1745017901511010180","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T11:31:33Z","timestamp":1451907093000},"page":"180-185","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The Burden of Depressive and Bipolar Disorders in Celiac Disease"],"prefix":"10.2174","volume":"11","author":[{"given":"Mauro","family":"Giovanni Carta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Conti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Lecca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Sancassiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Cossu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Carruxi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Boccone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Cadoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Pisanu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Francesca Moro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Demelia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"refR1","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/S0022-3999(02)00328-8","volume":"53","author":"Carta M.G.","year":"2002","unstructured":"Carta MG, Hardoy MC, Boi MF, Mariotti S, Carpiniello B, Usai P. \n                Association between panic disorder, major depressive disorder and celiac disease: a possible role of thyroid autoimmunity \n                J Psychosom Res  \n                2002; \n                53\n                (3)\n                : 789-93.","journal-title":"J. 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