{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:02:52Z","timestamp":1780696972059,"version":"3.54.1"},"reference-count":88,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["clinical-practice-and-epidemiology-in-mental-health.com","benthamopen.com"],"crossmark-restriction":true},"short-container-title":["CPEMH"],"published-print":{"date-parts":[[2021,12,24]]},"abstract":"\n Background:<\/jats:title>\n Increasing evidence highlights the susceptibility of Healthcare Workers to develop psychopathological sequelae, including Post-Traumatic Stress Disorder (PTSD) and depression, in the current COronaVIrus Disease-19 (COVID-19) pandemic, but little data have been reported in the acute phase of the pandemic.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To explore Healthcare Workers\u2019 mental health reactions in the acute phase of the COVID-19 pandemic in the first European epicenter (Lodi\/Codogno, Italy), with particular attention to post-traumatic stress and depressive symptoms and their interplay with other psychological outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n 74 Healthcare Workers employed at the Azienda Socio Sanitaria Territoriale of Lodi (Lombardy, Italy) were recruited and assessed by means of the Impact of Event Scale- Revised<\/jats:italic>, the Professional Quality of Life Scale-5<\/jats:italic>, the Patient Health Questionnaire-9<\/jats:italic>, the Generalized Anxiety Disorder-7 item<\/jats:italic>, the Resilience Scale<\/jats:italic> and the Work and Social Adjustment Scale<\/jats:italic>. Socio-demographic and clinical variables were compared across three subgroups of the sample (No PTSD, PTSD only, PTSD and depression).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A total of 31% of subjects endorsed a diagnosis of PTSD and 28.4% reported PTSD comorbid with major depression. Females were more prone to develop post-traumatic stress and depressive symptoms. Subjects with PTSD and depression groups showed high levels of PTSD, depression, burnout and impairment in functioning. Anxiety symptoms were higher in both PTSD and depression and PTSD groups rather than in the No PTSD group.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Our results showed high rates of PTSD and depression among Healthcare Workers and their comorbidity overall being associated with worse outcomes. Current findings suggest that interventions to prevent and treat psychological implications among Healthcare Workers facing infectious outbreaks are needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/1745017902117010242","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T05:07:53Z","timestamp":1640322473000},"page":"242-252","update-policy":"https:\/\/doi.org\/10.2174\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["PTSD and Depression in Healthcare Workers in the Italian Epicenter of the COVID-19 Outbreak"],"prefix":"10.2174","volume":"17","author":[{"given":"Claudia","family":"Carmassi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-893X","authenticated-orcid":true,"given":"Virginia","family":"Pedrinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Dell\u2019Oste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-0339","authenticated-orcid":true,"given":"Carlo Antonio","family":"Bertelloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Grossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Gesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Cerveri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6141-4993","authenticated-orcid":true,"given":"Liliana","family":"Dell\u2019Osso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S1092852920001637","volume":"1-2","author":"Carmassi C.","year":"2020","unstructured":"Carmassi C, Cerveri G, Bui E, Gesi C, Dell\u2019Osso L. \n Defining effective strategies to prevent post-traumatic stress in Healthcare emergency workers facing the COVID-19 pandemic in Italy. \n CNS Spectr \n 2020; \n 1-2\n : 1-2.","journal-title":"CNS Spectr."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S2213-2600(21)00068-0","volume":"9","author":"Mehta S.","year":"2021","unstructured":"Mehta S, Machado F, Kwizera A, et al. \n COVID-19: A heavy toll on health-care workers. \n Lancet Respir Med \n 2021; \n 9\n (3)\n : 226-8.","journal-title":"Lancet Respir. 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