{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:15:12Z","timestamp":1785129312876,"version":"3.55.0"},"reference-count":26,"publisher":"Bentham Science Publishers Ltd.","issue":"8","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["ACAMC"],"published-print":{"date-parts":[[2020,7,24]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Compounds containing furo[3,2-b]pyridine framework have shown interesting pharmacological\nproperties, including anticancer activities. Though these compounds are generally synthesized via the\nheteroannulation processes involving acetylenic derivatives, some of them are complex.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The study aimed to explore a series of 2-substituted furo[3,2-b]pyridines for their cytotoxic properties\nagainst cancer cell lines in vitro.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>We developed a convenient synthesis of 2-substituted furo[3,2-b]pyridines via sequential (i) C-C\ncoupling followed by (ii) C-O bond-forming reactions in a single pot. The reactions were performed under ultrasound\nirradiation in the presence of Pd\/C as an inexpensive, stable and widely used catalyst. A range of 2-\nsubstituted furo[3,2-b]pyridines were synthesized via coupling of 3-chloro-2-hydroxy pyridine with terminal\nalkynes in the presence of 10% Pd\/C-CuI-PPh3-Et3N in EtOH. The in vitro evaluation of all these compounds\nwas carried out against MDA-MB-231 and MCF-7 cell lines and subsequently against SIRT1.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The furo[3,2-b]pyridine derivative 3b showed encouraging growth inhibition of both MDAMB-231\nand MCF-7 cell lines and inhibition of SIRT1. The compound 3b also showed apoptosis-inducing potential\nwhen tested against MCF-7 cells.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The Pd\/C-Cu catalysis under ultrasound accomplished a one-pot and direct access to 2-substituted\nfuro[3,2-b]pyridine derivatives, some of which showed anticancer properties.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871520620666200311102304","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T13:45:00Z","timestamp":1583934300000},"page":"932-940","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Synthesis of 2-substituted Furo[3,2-b]pyridines Under Pd\/C-Cu Catalysis Assisted by Ultrasound: Their Evaluation as Potential Cytotoxic Agents"],"prefix":"10.2174","volume":"20","author":[{"given":"Dandamudi Sri","family":"Laxmi","sequence":"first","affiliation":[{"name":"Department of Chemistry, Krishna University, Machilipatnam-521 001, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suryadevara V.","family":"Vardhini","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Amritasai Institute of Science and Technology, Paritala, Krishna Dist., -521 180, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata R.","family":"Guttikonda","sequence":"additional","affiliation":[{"name":"Department of Chemistry, SRR & CVR Govt. 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