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Our current work investigates whether monensin has selective anti-ATC activity and systematically explores\nits underlying mechanisms.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Proliferation and apoptosis assays were performed using a panel of thyroid cancer cell lines. Mitochondrial\nbiogenesis profiles, ATP levels, oxidative stress, AMPK, and mTOR were examined in these cells after monensin\ntreatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Monensin is effective in inhibiting proliferation and inducing apoptosis in a number of thyroid cancer cell\nlines. The results are consistent across cell lines of varying cellular origins and genetic mutations. Compared to other\nthyroid cancer cell types, ATC cell lines are the most sensitive to monensin. Of note, monensin used at our experimental\nconcentration affects less of normal cells. Mechanistic studies reveal that monensin acts on ATC cells by disrupting\nmitochondrial function, inducing oxidative stress and damage, and AMPK activation-induced mTOR inhibition.\nWe further show that mitochondrial respiration is a critical target for monensin in ATC cells.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>Our pre-clinical findings demonstrate the selective anti-ATC activities of monensin. This is supported by\nincreasing evidence that monensin can be repurposed as a potential anti-cancer drug.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871520622666220215123620","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T04:58:21Z","timestamp":1644987501000},"page":"2539-2547","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Monensin Inhibits Anaplastic Thyroid Cancer <i>via<\/i> Disrupting Mitochondrial Respiration\nand AMPK\/mTOR Signaling"],"prefix":"10.2174","volume":"22","author":[{"given":"Yanli","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianshu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongjie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of\nOncology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Renmin\nHospital, Hubei University of Medicine, Shiyan, Hubei Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41574-019-0263-x","volume":"16","author":"Kim J.","year":"2020","unstructured":"Kim J.; Gosnell J.E.; Roman S.A.; Geographic influences in the global rise of thyroid cancer. 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