{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T08:21:52Z","timestamp":1761380512793,"version":"build-2065373602"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["AIAAMC"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Patients with chronic inflammatory diseases such as rheumatoid arthritis have a higher risk of cardiovascular\ndiseases and related mortality compared to the general population. This risk is first due to classical cardiovascular risk\nfactors but also due to systemic inflammation which is independently involved, causing accelerated atherosclerosis,\nmyocardial infarction, cerebrovascular disease and heart failure (HF). Pro-inflammatory cytokines such as tumor necrosis\nfactor-alpha (TNF-alpha), interleukin (IL)-1 and IL-6 could be major actors on this pathophysiology. Biologics are\neffective specific treatments in the management of inflammatory rheumatic and systemic diseases. In this review,\nbeneficial and deleterious effects on the heart and vessels of the biologics used in the management of inflammatory\narthritis and vasculitides will be discussed, focusing on TNF-alpha, IL-6 and IL-1 blockades, and anti-CD20. Noninflammatory\ncardiac conditions, such as heart failure, myocardial infarction, and cardiovascular conditions such as\natherosclerosis, as well as inflammatory diseases including vasculitides will be discussed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1871523011312010009","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T07:54:57Z","timestamp":1360914897000},"page":"68-82","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Biologics and the Cardiovascular System: A Double-Edged Sword"],"prefix":"10.2174","volume":"12","author":[{"given":"Camille","family":"Roubille","sequence":"first","affiliation":[{"name":"Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), Notre-Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, Canada.,Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanne","family":"Martel-Pelletier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boulos","family":"Haraoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Tardif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Pelletier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Anti-Inflammatory &amp; Anti-Allergy Agents in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1871523011312010009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/106695\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1871523011312010009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T08:17:36Z","timestamp":1761380256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/106695\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871523011312010009","relation":{},"ISSN":["1871-5230"],"issn-type":[{"type":"print","value":"1871-5230"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}