{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T17:10:39Z","timestamp":1711991439151},"reference-count":39,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["AIAAMC"],"published-print":{"date-parts":[[2019,7,24]]},"abstract":"<jats:sec>\n<jats:title>Introduction:<\/jats:title>\n<jats:p>Nowadays, the group of NSAIDs is used the most widely in order\nto treat the inflammatory process. But its long-term administration increases the risk of\ncomplications of pharmacotherapy. Therefore, today it is urgent to search for new molecules\nthat can selectively block biological targets that directly perceive inflammatory mediators.\nOne of such targets is TRPA1. ZC02-0012, a compound from the group of substituted\npyrazinopyrimidinones, which is a selective inhibitor of TRPA1 ion channel.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The aim of our study was to study the anti-inflammatory activity of an innovative\nmolecule under the laboratory code ZC02-0012 from the group of selective inhibitors\nof TRPA1 ion channel.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p> Anti-inflammatory activity of ZC02-0012 was studied on the\nmodel of acute exudative inflammation of the paw in response to subplantar injection in\nthe right hind paw of mice with 0.02 ml of 2% formaldehyde solution. The mass of the\npaw was measured after 4 hours (peak edema) after phlogistic injection. The test substance\nand the reference drug was administered intragastrically or intramuscularly 45 minutes before\nthe injection of formaldehyde solution. The presence and intensity of antiinflammatory\nactivity was judged by the inhibitory effect, represented in percent.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results and Discussion:<\/jats:title>\n<jats:p> Selective inhibitor of the TRPA1 ion channel ZC02-0012 revealed\nthe anti-inflammatory activity at doses of 3 and 9 mg\/kg, its intensity is comparable to diclofenac\nsodium.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> The selective inhibitor of the ion channel TRPA1, a substance under code\nZC02-0012, has an anti-inflammatory activity comparable with diclofenac sodium.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871523018666190208123700","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T06:40:44Z","timestamp":1549608044000},"page":"110-125","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels"],"prefix":"10.2174","volume":"18","author":[{"given":"Evgeniya A.","family":"Beskhmelnitsyna","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Clinical pharmacology, Medical Faculty of Belgorod National Research University, 85 Pobeda St., Belgorod, 308015, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail V.","family":"Pokrovskii","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical pharmacology, Medical Faculty of Belgorod National Research University, 85 Pobeda St., Belgorod, 308015, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandr L.","family":"Kulikov","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmacology of Living systems of Belgorod National Research University, 85 Pobeda St., Belgorod, 308015, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna A.","family":"Peresypkina","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical pharmacology, Medical Faculty of Belgorod National Research University, 85 Pobeda St., Belgorod, 308015, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeniy I.","family":"Varavin","sequence":"additional","affiliation":[{"name":"Physician Training Faculty for Aerospace Forces of Kirov Military Medical Academy, 6 Academician Lebedev St., Saint Petersburg, 194044, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"55","volume":"2","author":"Abramova S.N.","year":"2016","unstructured":"Abramova SN, Lazareva GA. 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