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The extract of P. staudtii potentiates the sleeping\ntime of hexobarbitone-induced hypnosis in a dose-related manner. P. staudtii stem bark extracts\nsignificantly (p&lt;0.05) prolonged the onset of a seizure and attenuated the duration of seizure in\na dose-dependent manner in picrotoxin- and or isoniazid-induced seizures. While, P. staudtii\nstem bark extract at all doses (100, 200, and 400 mg kg-1) though significantly prolonged the\nonset of action, but did not confer any significant changes on the duration, as well as mortality\nin this strychnine-induced seizure model. However, the anticonvulsant activity of the methanolic\nextract of P. staudtii was significantly reversed following intraperitoneal pre-treatment with\nflumazenil (GABA receptor antagonist) and naloxone (opioid receptor antagonist) but not cyproheptadine\n(5-HT2 receptor antagonist) in picrotoxin-induced convulsion.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> The data obtained suggest that methanol extract of P. staudtii possessed significant\nanticonvulsant effect, thereby confirming the traditional uses of P. staudtii in the treatment\nof epilepsy; mechanisms of which could involve the interaction with GABAergic and or\nopioidergic system.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871524920666200211113633","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T14:51:53Z","timestamp":1581432713000},"page":"144-154","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential Mechanisms Involved in the Anticonvulsant Effect of Methanol Extract of Pyrenancantha staudtii in Mice"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5341-1220","authenticated-orcid":true,"given":"Olayemi K.","family":"Wakeel","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences Osogbo, Ladoke Akintola University of Technology, Ogbomoso, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluropo B.","family":"Awosan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences Osogbo, Ladoke Akintola University of Technology, Ogbomoso, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oyetunji T.","family":"Kolawole","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences Osogbo, Ladoke Akintola University of Technology, Ogbomoso, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akeem A.","family":"Ayankunle","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences Osogbo, Ladoke Akintola University of Technology, Ogbomoso, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olukunle J.","family":"Onaolapo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Health Sciences Osogbo, Ladoke Akintola University of Technology, Ogbomoso, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwaseyi A.","family":"Adeyeba","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"9","volume":"1","author":"Vyawahare N.S.","year":"2007","unstructured":"Vyawahare N.S.; Khandelwal A.R.; Batra V.R.; Nikam A.P.; Herbal anticonvulsants. 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