{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:24:05Z","timestamp":1747207445970,"version":"3.40.5"},"reference-count":33,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CNSAMC"],"published-print":{"date-parts":[[2020,9,29]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Suaeda vermiculata is one of the widely distributed halophytes in central\nSaudi Arabia. The plant is used as a remedy for liver diseases, jaundice, and inflammation. S.\nvermiculata is also used as camels' food by local shepherds.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Purpose:<\/jats:title>\n<jats:p>The study aims to evaluate the behavioral antidepressant and anxiolytic effects of S.\nvermiculata aqueous and ethanol extracts.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Aqueous and ethanol extracts of S. vermiculata were prepared by the maceration technique.\nStandard forced swim test cylinder and light\/dark chamber device were used to evaluate the\nantidepressant and anxiolytic activities of the extracts (200 mg\/kg) in rats model, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> The aqueous and ethanol extracts of S. vermiculata showed remarkable antidepressant\nactivity with significant increase in the swimming time and reduced immobility in the rats compared\nto imipramine treated animals (P&lt;0.05). Ethanol extract increased the swimming time by\n20% and decreased the immobility time by more than 60% compared to the control group of animals.\nIn contrast, the extracts induced the anxiety behavior in experimental rats compared to vehicle-\ntreated animals. The extracts significantly (P&lt;0.001) reduced the time spent by rats in the\nlight chamber by more than 50% and increased the time spent in dark chamber as compared with\nthe control group and the group receiving diazepam.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The medicinally important plant S. vermiculata induced anxiety behavior with antidepressant\nactivity in rats. These effects from our point of view are similar to the effects of some\ncommon beverages containing caffeine such as coffee and tea.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871524920666200319142536","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T12:30:26Z","timestamp":1584621026000},"page":"122-127","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Behavioral Evaluation of the Effects of Aqueous and Ethanol Extracts of Suaeda vermiculata Forssk on Rats"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-6790","authenticated-orcid":true,"given":"Hamdoon A.","family":"Mohammed","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, 51452, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"author":"Mohammed H.A.","key":"ref=1","unstructured":"Mohammed H.A.;  The Valuable impacts of halophytic genus Suaeda; Nutritional, chemical, and biological values. 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