{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:53:10Z","timestamp":1780984390939,"version":"3.54.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CNSAMC"],"published-print":{"date-parts":[[2021,1,21]]},"abstract":"<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>The most common reason behind dementia is Alzheimer\u2019s disease (AD) and it is predicted\nto be the third life-threatening disease apart from stroke and cancer for the geriatric population.\nTill now, only four drugs are available on the market for symptomatic relief. The complex\nnature of disease pathophysiology and lack of concrete evidence of molecular targets are the major\nhurdles for developing a new drug to treat AD. The rate of attrition of many advanced drugs at\nclinical stages makes the de novo discovery process very expensive. Alternatively, Drug Repurposing\n(DR) is an attractive tool to develop drugs for AD in a less tedious and economic way. Therefore,\ncontinuous efforts are being made to develop a new drug for AD by repurposing old drugs\nthrough screening and data mining. For example, the survey in the drug pipeline for Phase III clinical\ntrials (till February 2019) consists of 27 candidates, and around half of the number are drugs\nwhich have already been approved for other indications.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>Although in the past, the drug repurposing process for AD has been reviewed in the context of disease\nareas, molecular targets, there is no systematic review of repurposed drugs for AD from the\nrecent drug development pipeline (2019-2020). In this manuscript, we have reviewed the clinical\ncandidates for AD with emphasis on their development history, including molecular targets and the\nrelevance of the target for AD.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871524920666201021164805","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T06:22:20Z","timestamp":1603347740000},"page":"157-176","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Old Drugs with New Tricks: Paradigm in Drug Development Pipeline for Alzheimer\u2019s Disease"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0086-3976","authenticated-orcid":true,"given":"Tanay","family":"Dalvi","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gujarat 380054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7309-8035","authenticated-orcid":true,"given":"Bhaskar","family":"Dewangan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gujarat 380054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1303-9997","authenticated-orcid":true,"given":"Rudradip","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gujarat 380054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-4793","authenticated-orcid":true,"given":"Jyoti","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gujarat 380054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-4901","authenticated-orcid":true,"given":"Suchita D.","family":"Shinde","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gujarat 380054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-3477","authenticated-orcid":true,"given":"Nazmina","family":"Vhora","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gujarat 380054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7365-7455","authenticated-orcid":true,"given":"Alok","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gujarat 380054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-9494","authenticated-orcid":true,"given":"Bichismita","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gujarat 380054, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Central Nervous System Agents in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/187090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/187090\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/187090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T15:54:49Z","timestamp":1611590089000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/187090\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,1,21]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871524920666201021164805","relation":{},"ISSN":["1871-5249"],"issn-type":[{"value":"1871-5249","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1,21]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication 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