{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:30:32Z","timestamp":1785796232779,"version":"3.56.0"},"reference-count":19,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CNSAMC"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Motivated by the exciting biological potential for the use of hybrid molecules\nin medicine and therapy. It is anticipated that the coumarin-chalcone hybrids for skeletal\nmuscle and antianxiety action will be investigated using a chemical hybridization technique.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Due to its numerous benefits, including high effectiveness, mode of action at receptors,\nminimal adverse effects, and improved pharmacokinetic features, naturally occurring and synthesized\nhybrid compounds are prospective sources for novel drug development techniques. In opinion\nof these applications, we here designed some coumarin-chalcone hybrids and explored them\nfor skeletal muscle and antianxiety potential.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Using a chemical hybridization strategy, coumarin-chalcone hybrids have been synthesized\nand evaluated for skeletal muscle and antianxiety activity. The target compounds were synthesized\nby reaction of 7-hydroxy-4-methylcoumarion with haloalkane to afford 7-(2-\nbromoethoxy)-4-methyl-2H-chromen-2-one which was further treated with hydroxychalcones. The\nstructures of target compounds were confirmed on the basis of their Melting Point, Thin Layer\nChromatography, IR, 1HNMR and Mass studies. The computational properties of target compounds\nwere also determined through online software. Skeletal muscle and antianxiety potential\nwere performed in Swiss albino mice.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The coumarin-chalcones hybrids showed skeletal muscle and antianxiety potential in\nSwiss albino mice and computational properties of the target compounds were also showed similarity\nas compared with diazepam.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Among the target compounds, the fluoro group containing compound was found to be\nmore potent as compared to the standard drug diazepam.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871524923666230130134501","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T04:18:15Z","timestamp":1675138695000},"page":"57-64","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis, Computational and Pharmacological Evaluation of 7-(2-(2- (3-\n(Substituted Phenyl) Acryloyl) Phenoxy) Ethoxy)-4-Methyl-2H-Chromen-\n2-Ones as CNS Agents"],"prefix":"10.2174","volume":"23","author":[{"given":"Sushil","family":"Kumar","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, IFTM University, Moradabad-244102 (U.P.), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, IFTM University, Moradabad-244102 (U.P.), India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"10846","DOI":"10.1039\/C5RA26294A","volume":"47","author":"Wei H.","year":"2016","unstructured":"Wei H.; Ruan J.; Zhang X.; Coumarin-Chalcone Hybrids: Promising agents with diverse pharmacological properties. 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