{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:59:38Z","timestamp":1740149978361,"version":"3.37.3"},"reference-count":18,"publisher":"Bentham Science Publishers Ltd.","issue":"2","funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","award":["6409"],"award-info":[{"award-number":["6409"]}],"id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["IDDT"],"published-print":{"date-parts":[[2020,5,14]]},"abstract":"<jats:sec>\n<jats:title>Background Context:<\/jats:title>\n<jats:p>Chronic Suppurative Otitis Media (CSOM) is a common cause\nof hearing impairment and disability. CSOM caused by Pseudomonas aeruginosa is usually\ntreated with topical ciprofloxacin and resistance to ciprofloxacin in CSOM isolates has rarely been\nreported.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case Presentation:<\/jats:title>\n<jats:p>A 24-year-old male patient with CSOM due to p. aeruginosa was reported.\nCSOM was prolonged for ten years and physician prescribed topical ciprofloxacin drops, pus suctioning\nand ear pH alteration. The treatment wasn\u2019t effective and the patient came back to the\nclinic with relapse of suppurative otitis media. P. aeruginosa was isolated as the cause of CSOM\nand the isolate was resistant to ciprofloxacin, aztreonam, imipenem, gentamicin, doripenem, cefepime,\nlevofloxacin, amikacin and susceptible to colistin and ceftazidime. There were two mutations\nin gyrA and eight mutations were observed in nfxB genes. Finally, tympanomastoidectomy\nwas done.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Usually topical antibiotics, especially ciprofloxacin, is effective against ear infections\nbut our case was different and the P. aeruginosa isolated from CSOM was resistant to most\nof the antibiotics. One reason for CSOM recurrence might be surgery failure. The routine and primary\ntreatment for CSOM did not seem sufficient and tympanomastoidectomy is suggested to be\nthe best treatment approach for these patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871526519666190228162001","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T16:52:42Z","timestamp":1589561562000},"page":"244-246","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Suppurative Otitis Media: A Case Report"],"prefix":"10.2174","volume":"20","author":[{"given":"M.M. 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