{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:01:46Z","timestamp":1756893706573},"reference-count":28,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["IDDT"],"published-print":{"date-parts":[[2021,5,20]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Neonatal sepsis is a clinical syndrome characterized by symptoms and\nsigns of infection in the first twenty-eight days of life. Serum thyroid, cortisol and hepcidin are affected\nby neonatal sepsis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Aim of the work:<\/jats:title>\n<jats:p>The aim of this study was to assess the diagnostic value of serum thyroid hormones\nincluding free triiodothyronine (free TT3) and free tetraiodothyronine (free TT4), serum cortisol\nand hepcidin levels through comparison of their concentrations between normal neonates and\nneonates with high probable late-onset sepsis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Patients and Methods:<\/jats:title>\n<jats:p>This case-control study was carried out on 40 neonates with suspected high\nprobable late-onset neonatal sepsis based on clinical and laboratory finding who were admitted to\nNICU of Pediatric Department, Tanta University, Egypt in the period from April 2017 to May\n2019 (group I) and 40 healthy neonates matched in age and sex as a control group (group II). For\npatients and controls, blood culture, highly sensitive C-reactive protein (H-s CRP), serum hepcidin,\nserum cortisol and thyroid hormones levels including free TT3 and free TT4 were assessed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>There were no significant differences between studied groups regarding weight, gestational\nage, sex and mode of delivery. H-s CRP, serum cortisol and hepcidin were significantly higher\nin group I than group II while serum-free TT3 and free TT4 were significantly lower in group I\ncompared with controls (group II). There was significantly lower H-s CRP, serum hepcidin and cortisol\nand significantly higher serum-free TT3 and free TT4 in group I after antibiotic therapy compared\nto the same group before treatment while there were no significant differences between\ngroup I after antibiotic therapy and control group (group II) regarding the same parameters. There\nwas a significant positive correlation between H-s CRP and serum hepcidin and cortisol in group I\nwhile there was a significant negative correlation between H-s CRP and free TT3 and free TT4.\nROC curve of specificity and sensitivity of H-s CRP, serum hepcidin, cortisol, free TT3 and free\nTT4 in the prediction of neonatal sepsis shows that serum hepcidin had the highest sensitivity and\nspecificity with 95% and 90% respectively followed by serum cortisol, H-s CRP, free TT3 and lastly\nfree TT4.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion and recommendations:<\/jats:title>\n<jats:p>Neonates with high probable sepsis had significantly higher\nserum cortisol and hepcidin and significantly lower free TT3 and free TT4 compared with healthy\nneonates. These findings may draw our attention about the use of these markers in the diagnosis of\nneonatal sepsis which can help in early treatment and subsequently better prognosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871526520666200327185244","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T16:22:23Z","timestamp":1585326143000},"page":"248-256","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic Value of Assessment of Serum Cortisol, Hepcidin and Thyroid Hormones Levels in Neonates with Late-Onset Sepsis"],"prefix":"10.2174","volume":"21","author":[{"given":"Adel A.","family":"Hagag","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed S.","family":"El Frargy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham L.","family":"Yonis","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada M.","family":"Al-Ashmawy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14767058.2019.1582633","volume":"13","author":"Mutlu M.","year":"2019","unstructured":"Mutlu M.; Aslan Y.; Akt\u00fcrk Acar F.; Kader \u015e.; Bayramo\u011flu G.; Y\u0131lmaz G.; Changing trend of microbiologic profile and antibiotic susceptibility of the microorganisms isolated in the neonatal nosocomial sepsis: a 14 years analysis. 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