{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:06:11Z","timestamp":1790229971370,"version":"4.1.0"},"reference-count":20,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["IDDT"],"published-print":{"date-parts":[[2021,5,20]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Premature infants are considered high-risk subgroup for neonatal sepsis\ndue to yet defective immune system, interventions practised and synergy of factors favoring multiple\nresistance of Gram-positive and Gram-negative pathogens to antimicrobial agents.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case presentation:<\/jats:title>\n<jats:p>We present a case of late-onset neonatal sepsis in a premature infant caused by\nan uncommon pathogen; a premature infant of extremely low birth weight had in his 4th week of\nlife severe clinical deterioration with lethargy, fever, pallor, mottling, abdominal distention, tachycardia,\nand worsening respiratory impairment. Full septic screen was performed, broad-spectrum\nantibiotic therapy was initiated and supportive care per needs was provided. Blood cultures (endotracheal\ntube tip cultures) isolated meropenem- and gentamicin-resistant strain of rare pathogen Ralstonia\nmannitolilytica. Ralstonia spp. are aerobic, Gram-negative, lactose non-fermenting, oxidaseand\ncatalase-positive bacilli, thriving in water and soil. Ralstonia spp. are identified only sporadically\nas causative agents of neonatal sepsis; to our knowledge, this is the second report of neonatal\nsepsis due to R. mannitolilytica in the literature so far. Our patient was eventually treated (per sensitivity\npattern) with intravenous ciprofloxacin and recovered well from the infection.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>We intend to raise awareness among neonatologists with regard to early detection of\nunusual pathogens, the emergence of antibiotic resistance patterns, and the obligation for adherence\nto infection control policies.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871526520666200330163504","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T14:43:21Z","timestamp":1585579401000},"page":"168-172","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ralstonia Mannitolilytica, an Unusual Pathogen in the Neonatal Intensive Care Unit: A Case of Neonatal Sepsis and Literature Review"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6244-633X","authenticated-orcid":true,"given":"Panagiotis","family":"Lampropoulos","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Neonatology, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1421-0813","authenticated-orcid":true,"given":"Despoina","family":"Gkentzi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Tzifas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Kapnisi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ageliki","family":"Karatza","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fevronia","family":"Kolonitsiou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7929-1573","authenticated-orcid":true,"given":"Gabriel","family":"Dimitriou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neonatology, University General Hospital of Patras, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/14787210.2019.1568871","volume":"17","author":"Dong Y.","year":"2019","unstructured":"Dong Y.; Glaser K.; Speer C.P.; Late-onset sepsis caused by Gram-negative bacteria in very low birth weight infants: a systematic review. 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