{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:35:36Z","timestamp":1794018936981,"version":"4.8.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"10","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CNSNDDT"],"published-print":{"date-parts":[[2018,11,23]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Objective: To investigate the efficacy of curcumin oral supplementation (600 mg\/day, Brainoil),\na natural antioxidant compound, in Amyotrophic Lateral Sclerosis (ALS).\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> Patients were randomized into two groups: Group A received placebo for 3 months, then\nBrainoil for the following 3 months, Group B took Brainoil for 6 months. The evaluations were conducted\nat basal (T0), after 3 months of double blinded Brainoil or placebo treatment (T1), and after the\n3 month open-label phase (T2). Clinical evaluations and oxidative stress biomarkers, including oxidative\nprotein products (AOPPs), ferric reducing ability (FRAP), total thiols (T-SH) and lactate, were\nevaluated, compared to a control group, during an incremental forearm exercise test.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> Over the entire study Group B showed a stable score of the ALS-FRS-r which decreased in\nGroup A (p&lt;0.01), in parallel with a reduction of AOPPs (p&lt;0.01) which was not detected into Group\nA. Also FRAP exercise values remained stable in Group B, while in Group A they were reduced without\ntreatment at T1 (0.05&lt;p&lt;0.01), for then increase at T2 with introduction of therapy (p&lt;0.05). In\nGroup B T1&gt;T0 exercise lactate was lower compared to Group A (p&lt;0.01). Compared to controls, the\nwhole ALS population showed a greater oxidative stress (p&lt;0.001), those treated with curcumin\n(Group B) exhibiting decreased exercise AOPPs at T2 with values approaching those of controls.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Although further studies are needed to confirm these data, treatment with curcumin\nshows encouraging results indicating a slight slowdown in disease progression, improving aerobic metabolism\nand oxidative damage, this also contributing to deepen knowledge into the pathogenic\nmechanisms of ALS.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871527317666180720162029","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T11:39:37Z","timestamp":1532345977000},"page":"767-779","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Amyotrophic Lateral Sclerosis and Oxidative Stress: A Double-Blind Therapeutic Trial After Curcumin Supplementation"],"prefix":"10.2174","volume":"17","author":[{"given":"Lucia","family":"Chico","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Caldarazzo","family":"Ienco","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza","family":"Bisordi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Lo Gerfo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Petrozzi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Petrucci","sequence":"additional","affiliation":[{"name":"Center of Neuromuscular and Neurological Rare Diseases, S. Camillo Forlanini Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelangelo","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Siciliano","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["CNS &amp; Neurological Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/163955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/163955\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/163955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T16:01:23Z","timestamp":1609257683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/163955\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,23]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,11,23]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871527317666180720162029","relation":{},"ISSN":["1871-5273"],"issn-type":[{"value":"1871-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11,23]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2017-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}