{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T02:00:20Z","timestamp":1794535220644,"version":"4.9.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CNSNDDT"],"published-print":{"date-parts":[[2019,7,17]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Fibromyalgia syndrome is a chronic multifaceted disease characterized by\nwidespread pain, muscle stiffness, fatigue, unrefreshing sleep and cognitive disorders. To date, no\nmedication has been shown to significantly improve pain, associated symptoms and Quality of Life in\nfibromyalgic patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> In this retrospective observational study, we analyzed data regarding 407 patients with\ndiagnosis of fibromyalgia syndrome who between 2013 and 2016 have been prescribed orally\nultramicronized palmitoylethanolamide tablets (Normast\u00ae Epitech Group SpA, Saccolongo, Italy) regardless\nof the concomitant pharmacological therapy (add-on treatment).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> Regarding efficacy, in the 359 analyzed patients, the change over time in Visual Analogue\nScale pain score was statistically significant, ranging from 75.84 (\u00b115.15) to 52.49 (\u00b116.73)\n(p&lt;0.001). Regarding quality of life, the change over time in Fibromyalgia Impact Questionnaire score\nwas statistically significant, ranging from 68.4 (\u00b114.1) to 49.1 (\u00b119.6) (p&lt;0.001). In the treated population,\nonly 36 patients (13,7%) reported Adverse Events predominantly of gastrointestinal type\n(diarrhea, dyspepsia, bloating, constipation, vomiting). Globally, 151 patients (57,63%) left the treatment\ndue to inefficacy.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> The results of ultramicronized palmitoylethanolamide treatment in this retrospective\nanalysis represent an important step for the development of a new and well-tolerated therapy for\nfibromyalgia syndrome, mostly suitable for these patients who need long-term treatments. Further\nmethodologically stronger studies will be necessary to validate our observation.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871527318666190227205359","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T12:03:15Z","timestamp":1551700995000},"page":"326-333","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Ultramicronized Palmitoylethanolamide (um-PEA) as Add-on Treatment in Fibromyalgia Syndrome (FMS): Retrospective Observational Study on 407 Patients"],"prefix":"10.2174","volume":"18","author":[{"given":"Vittorio","family":"Schweiger","sequence":"first","affiliation":[{"name":"Department of Surgery, Dentistry, Maternal and Infant Sciences, Pain Therapy Centre, Verona University Hospital, Policlinico GB Rossi, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvise","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Maternal and Infant Sciences, Pain Therapy Centre, Verona University Hospital, Policlinico GB Rossi, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bellamoli","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Maternal and Infant Sciences, Pain Therapy Centre, Verona University Hospital, Policlinico GB Rossi, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Donadello","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Maternal and Infant Sciences, Pain Therapy Centre, Verona University Hospital, Policlinico GB Rossi, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Schievano","sequence":"additional","affiliation":[{"name":"Innovative Statistical Research, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna D.","family":"Balzo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Public Health, Section of Forensic Medicine, Verona University Hospital, Policlinico GB Rossi, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piercarlo","family":"Sarzi-Puttini","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, ASST-Fatebenefratelli- L. Sacco University Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Parolini","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Maternal and Infant Sciences, Pain Therapy Centre, Verona University Hospital, Policlinico GB Rossi, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Polati","sequence":"additional","affiliation":[{"name":"Department of Surgery, Dentistry, Maternal and Infant Sciences, Pain Therapy Centre, Verona University Hospital, Policlinico GB Rossi, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["CNS &amp; Neurological Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/170278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T13:11:21Z","timestamp":1563714681000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/170278\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,17]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7,17]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871527318666190227205359","relation":{},"ISSN":["1871-5273"],"issn-type":[{"value":"1871-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7,17]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}