{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:00:17Z","timestamp":1740150017226,"version":"3.37.3"},"reference-count":110,"publisher":"Bentham Science Publishers Ltd.","issue":"6","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00ed\u00ecfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["444856\/2014-5"],"award-info":[{"award-number":["444856\/2014-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CNSNDDT"],"published-print":{"date-parts":[[2020,11,20]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Over the past few years, experimental research has been carried out to analyze the role of\nspecific receptors in depression to better understand the mechanisms and pathophysiological aspects of\nthe disease. In this paper, we aim to investigate the receptors family most involved in depression, as\nwell as the tissues in which most depression related-receptors are expressed. The article also aims to\nidentify the functions of the main receptors predominantly associated with the pathology. This review\nused a systematic methodology (Prospero; ID 168584) and followed the PRISMA guidelines. Studies\nwere searched in PubMed\/MEDLINE, Scientific Electronic Library Online, Web of Science, and Directory\nof Open Access Journals databases. Quantitative studies with conclusive results regarding receptors\ninvolved in depression were selected. The charts and network were made using R programming\nlanguage and statistical analyses were carried out using SPSS v25 software. It can be seen that G\nprotein-coupled receptors family is the most studied (p &lt; 0.05). These receptors are expressed in the\ncerebral cortex, basal ganglia, and can interact with each other. A great number of studies have evaluated\nreceptors related to beneficial effects in the disease (p &lt; 0.05). The inflammation response and\ncell survival\/proliferation are the main functions related to these receptors (p &lt; 0.01) and behavioral\ntests in mice are the main methodologies applied in these studies (p &lt; 0.05). Finally, the most influential\nprotein on the network of receptors involved in depression is the Bradykinin receptor B1. G protein-\ncoupled receptors located in cell membranes involving especially protective effects in depression\nand that expressed mainly in the cerebral cortex and basal ganglia have shown significant importance\nin this review. In addition, inflammation response or cell survival\/proliferation are the main functions\nperformed by the receptors related to depression as observed in this work.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871527319666200715102430","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T05:16:21Z","timestamp":1594876581000},"page":"417-436","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neural Receptors Associated with Depression: A Systematic Review of the Past 10 Years"],"prefix":"10.2174","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1974-4363","authenticated-orcid":true,"given":"Alice Barros","family":"C\u00e2mara","sequence":"first","affiliation":[{"name":"Department of Biophysics and Pharmacology, Bioscience Center, Federal University of Rio Grande do Norte, Natal\/RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-5014","authenticated-orcid":true,"given":"Igor Augusto","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande do Norte, Natal\/ RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.biopsych.2013.09.024","volume":"76","author":"Veeraiah P.","year":"2014","unstructured":"Veeraiah P.; Noronha J.M.; Maitra S.; Dysfunctional glutamatergic and \u03b3-aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression. Biol Psychiatry 2014,76(3),231-238","journal-title":"Biol Psychiatry"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"480","DOI":"10.2174\/1570159X1304150831123535","volume":"13","author":"Cui R.","year":"2015","unstructured":"Cui R.; A systematic review of depression. Curr Neuropharmacol 2015,13(4),480","journal-title":"Curr Neuropharmacol"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1159\/000346633","volume":"35","author":"Bjorklof G.H.","year":"2013","unstructured":"Bjorklof G.H.; Engedal K.; Selb\u00e6k G.; Kouwenhoven S.E.; Helvik A.S.; Coping and depression in old age: A literature review. Dement Geriatr Cogn Disord 2013,35(3-4),121-154","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref=4","first-page":"487","volume":"64","author":"Sibeoni J.","year":"2014","unstructured":"Sibeoni J.; Moro M.R.; Childhood and adolescent depression. Rev Prat 2014,64(4),487-490","journal-title":"Rev Prat"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/geriatrics2040035","volume":"2","author":"Girgus J.S.","year":"2017","unstructured":"Girgus J.S.; Yang K.; Ferri C.V.; The gender difference in depression: Are elderly women at greater risk for depression than elderly men? Geriatrics (Basel) 2017,2(4),35","journal-title":"Geriatrics (Basel)"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1186\/s12889-019-6730-4","volume":"19","author":"Schlax J.","year":"2019","unstructured":"Schlax J.; J\u00fcnger C.; Beutel M.E.; Income and education predict elevated depressive symptoms in the general population: Results from the Gutenberg health study. BMC Public Health 2019,19(1),430","journal-title":"BMC Public Health"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.psychres.2016.06.022","volume":"242","author":"Farrell C.","year":"2016","unstructured":"Farrell C.; O\u2019Keane V.; Epigenetics and the glucocorticoid receptor: A review of the implications in depression. Psychol Res 2016,242,349-356","journal-title":"Psychol Res"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.psyneuen.2016.11.031","volume":"76","author":"Lindqvist D.","year":"2017","unstructured":"Lindqvist D.; Dhabhar F.S.; James S.J.; Oxidative stress, inflammation and treatment response in major depression. Psychoneuroendocrinology 2017,76,197-205","journal-title":"Psychoneuroendocrinology"},{"journal-title":"World Health Organization Mental Health governance","key":"ref=9","unstructured":"World Health Organization Mental Health governance"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/515180a","volume":"515","author":"Smith K.","year":"2014","unstructured":"Smith K.; De Torres I.B.C.; Mental health: A world of depression. Nature 2014,515(7526),181","journal-title":"Nature"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12974-019-1475-7","volume":"16","author":"Liu C.H.","year":"2019","unstructured":"Liu C.H.; Zhang G.Z.; Li B.; Role of inflammation in depression relapse. J Neuroinflammation 2019,16(1),90","journal-title":"J Neuroinflammation"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3389\/fncel.2015.00476","volume":"9","author":"Brites D.","year":"2015","unstructured":"Brites D.; Fernandes A.; Neuroinflammation and depression: Microglia activation, extracellular microvesicles and microRNA dysregulation. Front Cell Neurosci 2015,9,476","journal-title":"Front Cell Neurosci"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1742-2094-7-98","volume":"7","author":"Viana A.F.","year":"2010","unstructured":"Viana A.F.; Maciel I.S.; Dornelles F.N.; Kinin B1 receptors mediate depression-like behavior response in stressed mice treated with systemic E. coli lipopolysaccharide. J Neuroinflammation 2010,7(1),98","journal-title":"J Neuroinflammation"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"667","DOI":"10.3390\/cancers12030667","volume":"12","author":"Sun D.P.","year":"2020","unstructured":"Sun D.P.; Lee Y.W.; Chen J.T.; Lin Y.W.; Chen R.M.; The Bradykinin-BDKRB1 axis regulates aquaporin 4 gene expression and consequential migration and invasion of malignant glioblastoma cells via a Ca2+-MEK1-ERK1\/2-NF-\u03baB mechanism. Cancers (Basel) 2020,12,667","journal-title":"Cancers (Basel)"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/nm.1980","volume":"15","author":"Schulze-Topphoff U.","year":"2009","unstructured":"Schulze-Topphoff U.; Prat A.; Prozorovski T.; Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system. Nat Med 2009,15(7),788-793","journal-title":"Nat Med"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/bph.12116","volume":"169","author":"Souza P.P.C.","year":"2013","unstructured":"Souza P.P.C.; Brechter A.B.; Reis R.I.; Costa C.A.S.; Lundberg P.; Lerner U.H.; IL-4 and IL-13 inhibit IL-1\u03b2 and TNF-\u03b1 induced kinin B1 and B2 receptors through a STAT6-dependent mechanism. Br J Pharmacol 2013,169(2),400-412","journal-title":"Br J Pharmacol"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/1177271917704193","volume":"12","author":"Gustafsson A.","year":"2017","unstructured":"Gustafsson A.; Ventorp F.; Wis\u00e9n A.G.; Ohlsson L.; Ljunggren L.; Westrin \u00c5.; Effects of acute exercise on circulating soluble form of the urokinase receptor in patients with major depressive disorder. Biomark Insights 2017,12,1-10","journal-title":"Biomark Insights"},{"key":"ref=18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110555","volume":"9","author":"Haastrup E.","year":"2014","unstructured":"Haastrup E.; Grau K.; Eugen-Olsen J.; Thorball C.; Kessing L.V.; Ullum H.; Soluble urokinase plasminogen activator receptor as a marker for use of antidepressants. PLoS One 2014,9(10)","journal-title":"PLoS One"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.2741\/4363","volume":"20","author":"Wang Q.","year":"2015","unstructured":"Wang Q.; Liu D.; Song P.; Zou M.H.; Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation. Front Biosci 2015,20,1116-1143","journal-title":"Front Biosci"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","volume":"82","author":"North R.A.","year":"2002","unstructured":"North R.A.; Molecular physiology of P2X receptors. Physiol Rev 2002,82(4),1013-1067","journal-title":"Physiol Rev"},{"key":"ref=21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153677","volume":"11","author":"Freitas H.R.","year":"2016","unstructured":"Freitas H.R.; Ferraz G.; Ferreira G.C.; Glutathione-induced calcium shifts in chick retinal glial cells. PLoS One 2016,11(4)","journal-title":"PLoS One"},{"key":"ref=22","doi-asserted-by":"publisher","DOI":"10.1080\/23262133.2017.1283188","volume":"4","author":"Freitas H.R.","year":"2017","unstructured":"Freitas H.R.; Reis R.A.; Glutathione induces GABA release through P2X7R activation on M\u00fcller glia. Neurogenesis (Austin) 2017,4(1)","journal-title":"Neurogenesis (Austin)"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/nm1082","volume":"10","author":"Wang X.","year":"2004","unstructured":"Wang X.; Arcuino G.; Takano T.; P2X7 receptor inhibition improves recovery after spinal cord injury. Nat Med 2004,10(8),821-827","journal-title":"Nat Med"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.psyneuen.2018.07.016","volume":"97","author":"Farooq R.K.","year":"2018","unstructured":"Farooq R.K.; Tanti A.; Ainouche S.; Roger S.; Belzung C.; Camus V.A.; P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an Unpredictable Chronic Mild Stress (UCMS) model of depression in mice. Psychoneuroendocrinology 2018,97,120-130","journal-title":"Psychoneuroendocrinology"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.pnpbp.2019.01.006","volume":"92","author":"Vereczkei A.","year":"2019","unstructured":"Vereczkei A.; Abdul-Rahman O.; Halmai Z.; Association of purinergic receptor P2RX7 gene polymorphisms with depression symptoms. Prog Neuropsychopharmacol Biol Psychiatry 2019,92,207-216","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1093\/ijnp\/pyx046","volume":"20","author":"Otrokocsi L.","year":"2017","unstructured":"Otrokocsi L.; Kittel \u00c1.; Sperl\u00e1gh B.; P2X7 receptors drive spine synapse plasticity in the learned helplessness model of depression. Int J Neuropsychopharmacol 2017,20(10),813-822","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s12974-019-1474-8","volume":"16","author":"Guo L.T.","year":"2019","unstructured":"Guo L.T.; Wang S.Q.; Su J.; Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K\/AKT\/FoxO1 pathway. J Neuroinflammation 2019,16(1),95","journal-title":"J Neuroinflammation"},{"key":"ref=28","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1525","volume":"10","author":"Zhang K.","year":"2020","unstructured":"Zhang K.; Lin W.; Zhang J.; Zhao Y.; Wang X.; Zhao M.; Effect of Toll-like receptor 4 on depressive-like behaviors induced by chronic social defeat stress. Brain Behav 2020,10(3)","journal-title":"Brain Behav"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3389\/fnins.2019.00364","volume":"13","author":"Guo L.","year":"2019","unstructured":"Guo L.; Niu M.; Yang J.; GHS-R1a deficiency alleviates depression-related behaviors after chronic social defeat stress. Front Neurosci 2019,13,364","journal-title":"Front Neurosci"},{"key":"ref=30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112250","volume":"379","author":"Costa R.","year":"2020","unstructured":"Costa R.; Tamascia M.L.; Sanches A.; Tactile stimulation of adult rats modulates hormonal responses, depression-like behaviors, and memory impairment induced by chronic mild stress: Role of angiotensin II. Behav Brain Res 2020,379","journal-title":"Behav Brain Res"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3389\/fphar.2019.00705","volume":"10","author":"Costa-Ferreira W.","year":"2019","unstructured":"Costa-Ferreira W.; Morais-Silva G.; Gomes-de-Souza L.; Marin M.T.; Crestani C.C.; The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in rats. Front Pharmacol 2019,10,705","journal-title":"Front Pharmacol"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.2174\/1568026619666190709092647","volume":"19","author":"Liao C.","year":"2019","unstructured":"Liao C.; de Molliens M.P.; Schneebeli S.T.; Targeting the PAC1 receptor for neurological and metabolic disorders. Curr Top Med Chem 2019,19(16),1399-1417","journal-title":"Curr Top Med Chem"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/bs.pmbts.2019.06.009","volume":"167","author":"Lutfy K.","year":"2019","unstructured":"Lutfy K.; Shankar G.; Emerging evidence for the role of pituitary adenylate cyclase-activating peptide in neuropsychiatric disorders. Prog Mol Biol Transl Sci 2019,167,143-157","journal-title":"Prog Mol Biol Transl Sci"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1248\/bpb.b17-00082","volume":"40","author":"Aizawa F.","year":"2017","unstructured":"Aizawa F.; Ogaki Y.; Kyoya N.; The deletion of GPR40\/FFAR1 signaling damages maternal care and emotional function in female mice. Biol Pharm Bull 2017,40(8),1255-1259","journal-title":"Biol Pharm Bull"},{"key":"ref=35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1254\/jphs.14001SC","volume":"125","author":"Nishinaka T.","year":"2014","unstructured":"Nishinaka T.; Yamashita T.; Nakamoto K.; Kasuya F.; Tokuyama S.; Involvement of the long-chain fatty acid receptor GPR40 in depression-related behavior. J Pharmacol Sci 2014,125(1),112-115","journal-title":"J Pharmacol Sci"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1038\/s41467-019-09562-7","volume":"10","author":"Holmes S.E.","year":"2019","unstructured":"Holmes S.E.; Scheinost D.; Finnema S.J.; Lower synaptic density is associated with depression severity and network alterations. Nat Commun 2019,10(1),1529","journal-title":"Nat Commun"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/978-3-0346-0226-6_14","volume":"Vol. 03","author":"Ehlen J.C.","year":"2010","unstructured":"Ehlen J.C.; Hummer D.L.; Paul K.N.; Albers H.E.;  GABA involvement in the circadian regulation of sleep GABA and Sleep 2010,Vol. 03,321","journal-title":"GABA involvement in the circadian regulation of sleep GABA and Sleep"},{"key":"ref=38","first-page":"1262","volume":"57","author":"Follesa P.","year":"2000","unstructured":"Follesa P.; Serra M.; Cagetti E.; Allopregnanolone synthesis in cerebellar granule cells: Roles in regulation of GABA(A) receptor expression and function during progesterone treatment and withdrawal. Mol Pharmacol 2000,57(6),1262-1270","journal-title":"Mol Pharmacol"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1615\/CritRevNeurobiol.v14.i1.20","volume":"14","author":"Sanacora G.","year":"2000","unstructured":"Sanacora G.; Mason G.F.; Krystal J.H.; Impairment of GABAergic transmission in depression: New insights from neuroimaging studies. Crit Rev Neurobiol 2000,14(1),23-45","journal-title":"Crit Rev Neurobiol"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fendo.2011.00055","volume":"2","author":"Longone P.","year":"2011","unstructured":"Longone P.; di Michele F.; D\u2019Agati E.; Romeo E.; Pasini A.; Rupprecht R.; Neurosteroids as neuromodulators in the treatment of anxiety disorders. Front Endocrinol (Lausanne) 2011,2,55","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1096\/fasebj.6.6.1347506","volume":"6","author":"Paul S.M.","year":"1992","unstructured":"Paul S.M.; Purdy R.H.; Neuroactive steroids. FASEB J 1992,6(6),2311-2322","journal-title":"FASEB J"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1089\/acm.2010.0007","volume":"16","author":"Streeter C.C.","year":"2010","unstructured":"Streeter C.C.; Whitfield T.H.; Owen L.; Effects of yoga versus walking on mood, anxiety, and brain GABA levels: A randomized controlled MRS study. J Altern Complement Med 2010,16(11),1145-1152","journal-title":"J Altern Complement Med"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3389\/fncel.2019.00087","volume":"13","author":"Foga\u00e7a M.V.","year":"2019","unstructured":"Foga\u00e7a M.V.; Duman R.S.; Cortical GABAergic dysfunction in stress and depression: New insights for therapeutic interventions. Front Cell Neurosci 2019,13,87","journal-title":"Front Cell Neurosci"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3389\/fnbeh.2014.00008","volume":"8","author":"Creed M.C.","year":"2014","unstructured":"Creed M.C.; Ntamati N.R.; Tan K.R.; VTA GABA neurons modulate specific learning behaviors through the control of dopamine and cholinergic systems. Front Behav Neurosci 2014,8,8","journal-title":"Front Behav Neurosci"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1016\/j.neuron.2012.02.016","volume":"73","author":"van Zessen R.","year":"2012","unstructured":"van Zessen R.; Phillips J.L.; Budygin E.A.; Stuber G.D.; Activation of VTA GABA neurons disrupts reward consumption. Neuron 2012,73(6),1184-1194","journal-title":"Neuron"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1093\/schbul\/9.3.336","volume":"9","author":"Garbutt J.C.","year":"1983","unstructured":"Garbutt J.C.; van Kammen D.P.; The interaction between GABA and dopamine: Implications for schizophrenia. Schizophr Bull 1983,9(3),336-353","journal-title":"Schizophr Bull"},{"key":"ref=47","first-page":"1867","volume":"9","author":"Shimizu H.","year":"2013","unstructured":"Shimizu H.; Takebayashi M.; Tani M.; Sigma-1 receptor concentration in plasma of patients with late-life depression: A preliminary study. Neuropsychiatr Dis Treat 2013,9,1867-1872","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"H1521","DOI":"10.1152\/ajpheart.00607.2017","volume":"315","author":"Liu X.","year":"2018","unstructured":"Liu X.; Qu C.; Yang H.; Chronic stimulation of the sigma-1 receptor ameliorates autonomic nerve dysfunction and atrial fibrillation susceptibility in a rat model of depression. Am J Physiol Heart Circ Physiol 2018,315(6),H1521-H1531","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00213-015-4131-7","volume":"233","author":"Lee J.H.","year":"2016","unstructured":"Lee J.H.; Koh S.Q.; Guadagna S.; Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer\u2019s disease patients. Psychopharmacology (Berl) 2016,233(4),591-598","journal-title":"Psychopharmacology (Berl)"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1111\/bph.14774","volume":"176","author":"Marwari S.","year":"2019","unstructured":"Marwari S.; Poulsen A.; Shih N.; Intranasal administration of a stapled relaxin-3 mimetic has anxiolytic- and antidepressant-like activity in rats. Br J Pharmacol 2019,176(20),3899-3923","journal-title":"Br J Pharmacol"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s12640-018-9959-2","volume":"35","author":"Poleszak E.","year":"2019","unstructured":"Poleszak E.; Szopa A.; Bogatko K.; Antidepressant-like activity of typical antidepressant drugs in the forced swim test and tail suspension test in mice is augmented by DMPX, an Adenosine A2A receptor antagonist. Neurotox Res 2019,35(2),344-352","journal-title":"Neurotox Res"},{"key":"ref=52","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104338","volume":"147","author":"Domenici M.R.","year":"2019","unstructured":"Domenici M.R.; Ferrante A.; Martire A.; Adenosine A2A receptor as potential therapeutic target in neuropsychiatric disorders. Pharmacol Res 2019,147","journal-title":"Pharmacol Res"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.pharep.2019.03.007","volume":"71","author":"Szopa A.","year":"2019","unstructured":"Szopa A.; Bogatko K.; Serefko A.; Agomelatine and tianeptine antidepressant activity in mice behavioral despair tests is enhanced by DMPX, a selective adenosine A2A receptor antagonist, but not DPCPX, a selective adenosine A1 receptor antagonist. Pharmacol Rep 2019,71(4),676-681","journal-title":"Pharmacol Rep"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3389\/fphar.2018.00526","volume":"9","author":"L\u00f3pez-Cruz L.","year":"2018","unstructured":"L\u00f3pez-Cruz L.; Salamone J.D.; Correa M.; Caffeine and selective adenosine receptor antagonists as new therapeutic tools for the motivational symptoms of depression. Front Pharmacol 2018,9,526","journal-title":"Front Pharmacol"},{"key":"ref=55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.172948","volume":"872","author":"Browne C.A.","year":"2020","unstructured":"Browne C.A.; Smith T.; Lucki I.; Behavioral effects of the kappa opioid receptor partial agonist nalmefene in tests relevant to depression. Eur J Pharmacol 2020,872(5)","journal-title":"Eur J Pharmacol"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1038\/s41598-019-39622-3","volume":"9","author":"Nobile B.","year":"2019","unstructured":"Nobile B.; Ramoz N.; Jaussent I.; Polymorphism A118G of opioid receptor mu 1 (OPRM1) is associated with emergence of suicidal ideation at antidepressant onset in a large naturalistic cohort of depressed outpatients. Sci Rep 2019,9(1),2569","journal-title":"Sci Rep"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/76061","volume":"25","author":"Filliol D.","year":"2000","unstructured":"Filliol D.; Ghozland S.; Chluba J.; Mice deficient for \u03b4- and \u03bc-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet 2000,25(2),195-200","journal-title":"Nat Genet"},{"key":"ref=58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112533","volume":"251","author":"Gong W.","year":"2020","unstructured":"Gong W.; Zhou Y.; Gong W.; Qin X.; Coniferyl ferulate exerts antidepressant effect via inhibiting the activation of NMDAR-CaMKII-MAPKs and mitochondrial apoptotic pathways. J Ethnopharmacol 2020,251(6)","journal-title":"J Ethnopharmacol"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1093\/ijnp\/pyaa025","volume":"23","author":"Park L.T.","year":"2020","unstructured":"Park L.T.; Kadriu B.; Gould T.D.; A randomized trial of the N-methyl-d-aspartate receptor glycine site antagonist prodrug 4-chlorokynurenine in treatment-resistant depression. Int J Neuropsychopharmacol 2020,23(7),417-425","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref=60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116778","volume":"412","author":"Kalmoe M.C.","year":"2020","unstructured":"Kalmoe M.C.; Janski A.M.; Zorumski C.F.; Nagele P.; Palanca B.J.; Conway C.R.; Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents. J Neurol Sci 2020,412","journal-title":"J Neurol Sci"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1503\/jpn.160175","volume":"42","author":"Aleksandrova L.R.","year":"2017","unstructured":"Aleksandrova L.R.; Phillips A.G.; Wang Y.T.; Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism. J Psychiatry Neurosci 2017,42(4),222-229","journal-title":"J Psychiatry Neurosci"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"861","DOI":"10.2174\/1570159X18666200303104235","volume":"18","author":"Chen K.","year":"2020","unstructured":"Chen K.; Yang L.N.; Lai C.; Liu D.; Zhu L.Q.; Role of GRINA\/NMDARA1 in central nervous system diseases. Curr Neuropharmacol 2020,18(9),861-867","journal-title":"Curr Neuropharmacol"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.pnpbp.2013.04.009","volume":"45","author":"Hamon M.","year":"2013","unstructured":"Hamon M.; Blier P.; Monoamine neurocircuitry in depression and strategies for new treatments. Prog Neuropsychopharmacol Biol Psychiatry 2013,45,54-63","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref=64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113612","volume":"9","author":"de Kwaasteniet B.P.","year":"2014","unstructured":"de Kwaasteniet B.P.; Pinto C.; Ruh\u00e9 H.G.; van Wingen G.A.; Booij J.; Denys D.; Striatal dopamine D2\/3 receptor availability in treatment resistant depression. PLoS One 2014,9(11)","journal-title":"PLoS One"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1007\/s00259-017-3664-x","volume":"44","author":"Zoons E.","year":"2017","unstructured":"Zoons E.; Tijssen M.A.J.; Dreissen Y.E.M.; Speelman J.D.; Smit M.; Booij J.; The relationship between the dopaminergic system and depressive symptoms in cervical dystonia. Eur J Nucl Med Mol Imaging 2017,44(8),1375-1382","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.nbd.2010.03.020","volume":"39","author":"Beyer C.E.","year":"2010","unstructured":"Beyer C.E.; Dwyer J.M.; Piesla M.J.; Depression-like phenotype following chronic CB1 receptor antagonism. Neurobiol Dis 2010,39(2),148-155","journal-title":"Neurobiol Dis"},{"key":"ref=67","first-page":"44","volume":"5","author":"Kucerova J.","year":"2014","unstructured":"Kucerova J.; Giugliano V.; Babinska Z.; Enhanced self-administration of the CB1 receptor agonist WIN55, 212-2 in olfactory bulbectomized rats: Evaluation of possible serotonergic and dopaminergic underlying mechanisms. Front Pharmacol 2014,5,44","journal-title":"Front Pharmacol"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1159\/000480001","volume":"42","author":"He X.","year":"2017","unstructured":"He X.; Yang L.; Wang M.; Targeting the Endocannabinoid\/CB1 receptor system for treating major depression through antidepressant activities of curcumin and dexanabinol-loaded solid lipid nanoparticles. Cell Physiol Biochem 2017,42(6),2281-2294","journal-title":"Cell Physiol Biochem"},{"key":"ref=69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.107703","volume":"167","author":"Ohmura Y.","year":"2020","unstructured":"Ohmura Y.; Tsutsui-Kimura I.; Sasamori H.; Different roles of distinct serotonergic pathways in anxiety-like behavior, antidepressant-like, and anti-impulsive effects. Neuropharmacology 2020,167","journal-title":"Neuropharmacology"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.lfs.2018.08.050","volume":"210","author":"\u017bmudzka E.","year":"2018","unstructured":"\u017bmudzka E.; Sa\u0142aciak K.; Sapa J.; Pytka K.; Serotonin receptors in depression and anxiety: Insights from animal studies. Life Sci 2018,210,106-124","journal-title":"Life Sci"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0033291720000604","volume":"2020","author":"Murphy S.E.","year":"2020","unstructured":"Murphy S.E.; de Cates A.N.; Gillespie A.L.; Translating the promise of 5HT4 receptor agonists for the treatment of depression. Psychol Med 2020,2020,1-10","journal-title":"Psychol Med"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/mp.2016.120","volume":"22","author":"Keller J.","year":"2017","unstructured":"Keller J.; Gomez R.; Williams G.; HPA axis in major depression: Cortisol, clinical symptomatology and genetic variation predict cognition. Mol Psychiatry 2017,22(4),527-536","journal-title":"Mol Psychiatry"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3389\/fnbeh.2013.00035","volume":"7","author":"Poirier G.L.","year":"2013","unstructured":"Poirier G.L.; Cordero M.I.; Sandi C.; Female vulnerability to the development of depression-like behavior in a rat model of intimate partner violence is related to anxious temperament, coping responses, and amygdala vasopressin receptor 1a expression. Front Behav Neurosci 2013,7,35","journal-title":"Front Behav Neurosci"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"4813","DOI":"10.1007\/s12035-016-0043-8","volume":"54","author":"Lesse A.","year":"2017","unstructured":"Lesse A.; Rether K.; Gr\u00f6ger N.; Braun K.; Bock J.; Chronic postnatal stress induces depressive-like behavior in male mice and programs second-hit stress-induced gene expression patterns of OxtR and AvpR1a in adulthood. Mol Neurobiol 2017,54(6),4813-4819","journal-title":"Mol Neurobiol"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1242\/dmm.017053","volume":"7","author":"Charles R.","year":"2014","unstructured":"Charles R.; Sakurai T.; Takahashi N.; Introduction of the human AVPR1A gene substantially alters brain receptor expression patterns and enhances aspects of social behavior in transgenic mice. Dis Model Mech 2014,7(8),1013-1022","journal-title":"Dis Model Mech"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.pnpbp.2012.05.018","volume":"39","author":"Chiba S.","year":"2012","unstructured":"Chiba S.; Numakawa T.; Ninomiya M.; Richards M.C.; Wakabayashi C.; Kunugi H.; Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry 2012,39(1),112-119","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.pnpbp.2017.07.024","volume":"79","author":"Wang SS","year":"2017","unstructured":"Wang SS; Mu RH; Li CF;  microRNA-124 targets glucocorticoid receptor and is involved in depression-like behaviors. Prog Neuropsychopharmacol Biol Psychiat  2017,79(Pt B),417-25"},{"key":"ref=78","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.pnpbp.2018.02.004","volume":"84","author":"Kang HJ","year":"2018","unstructured":"Kang HJ; Bae KY; Kim SW;  Longitudinal associations between glucocorticoid receptor methylation and late-life depression Prog Neuropsychopharmacol Biol Psychiat 2018,84(Pt B),56-62","journal-title":"Longitudinal associations between glucocorticoid receptor methylation and late-life depression Prog Neuropsychopharmacol Biol Psychiat"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1093\/ijnp\/pyz008","volume":"22","author":"Chen F.","year":"2019","unstructured":"Chen F.; Yu X.; Meng G.; Hippocampal genetic knockdown of PPAR\u03b4 causes depression-like behaviors and neurogenesis suppression. Int J Neuropsychopharmacol 2019,22(6),372-382","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref=80","volume":"2015","author":"Wang F.R.","year":"2015","unstructured":"Wang F.R.; Qiao M.Q.; Xue L.; Wei S.; Possible involvement of \u00b5 opioid receptor in the antidepressant-like effect of shuyu formula in restraint stress-induced depression-like rats. Evid Based Complement Alternat Med 2015,2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref=81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.172918","volume":"871","author":"Imam M.Z.","year":"2020","unstructured":"Imam M.Z.; Kuo A.; Ghassabian S.; Intracerebroventricular administration of CYX-6, a potent \u03bc-opioid receptor agonist, a \u03b4- and \u03ba-opioid receptor antagonist and a biased ligand at \u03bc, \u03b4","journal-title":"Eur J Pharmacol"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1254\/jphs.10136SC","volume":"114","author":"Ide S.","year":"2010","unstructured":"Ide S.; Fujiwara S.; Fujiwara M.; Antidepressant-like effect of venlafaxine is abolished in \u03bc-opioid receptor-knockout mice. J Pharmacol Sci 2010,114(1),107-110","journal-title":"J Pharmacol Sci"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"8853","DOI":"10.1096\/fj.201802359RR","volume":"33","author":"Chai H.H.","year":"2019","unstructured":"Chai H.H.; Fu X.C.; Ma L.; The chemokine CXCL1 and its receptor CXCR2 contribute to chronic stress-induced depression in mice. FASEB J 2019,33(8),8853-8864","journal-title":"FASEB J"},{"key":"ref=84","first-page":"49","volume":"50","author":"Colle R.","year":"2017","unstructured":"Colle R.; de Larminat D.; Rotenberg S.; PPAR-\u03b3 agonists for the treatment of major depression: A review. Pharmacopsychiatry 2017,50(2),49-55","journal-title":"Pharmacopsychiatry"},{"key":"ref=85","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154860","volume":"125","author":"Salmani H.","year":"2020","unstructured":"Salmani H.; Hosseini M.; Baghcheghi Y.; Moradi-Marjaneh R.; Mokhtari-Zaer A.; Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-\u03b3 activation. Cytokine 2020,125","journal-title":"Cytokine"},{"key":"ref=86","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.pbb.2019.03.002","volume":"180","author":"Naserzadeh R.","year":"2019","unstructured":"Naserzadeh R.; Abad N.; Ghorbanzadeh B.; Dolatshahi M.; Mansouri M.T.; Simvastatin exerts antidepressant-like activity in mouse forced swimming test: Role of NO-cGMP-KATP channels pathway and PPAR-gamma receptors. Pharmacol Biochem Behav 2019,180,92-100","journal-title":"Pharmacol Biochem Behav"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1007\/s11064-019-02840-2","volume":"44","author":"Xiao D.","year":"2019","unstructured":"Xiao D.; Liu L.; Li Y.; Ruan J.; Wang H.; Licorisoflavan A.; Licorisoflavan A exerts antidepressant-like effect in mice: Involvement of BDNF-TrkB pathway and AMPA receptors. Neurochem Res 2019,44(9),2044-2056","journal-title":"Neurochem Res"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.neuron.2018.10.018","volume":"100","author":"Diering G.H.","year":"2018","unstructured":"Diering G.H.; Huganir R.L.; The AMPA receptor code of synaptic plasticity. Neuron 2018,100(2),314-329","journal-title":"Neuron"},{"key":"ref=89","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2020.172913","volume":"192","author":"Pham T.H.","year":"2020","unstructured":"Pham T.H.; Defaix C.; Nguyen T.M.L.; Cortical and raphe GABAA, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine. Pharmacol Biochem Behav 2020,192","journal-title":"Pharmacol Biochem Behav"},{"key":"ref=90","doi-asserted-by":"crossref","first-page":"e455","DOI":"10.1016\/j.wneu.2020.04.042","volume":"139","author":"Jiang L.","year":"2020","unstructured":"Jiang L.; Zhang H.; Zhou J.; Involvement of hippocampal AMPA receptors in electroacupuncture attenuating depressive-like behaviors and regulating synaptic proteins in rats subjected to chronic unpredictable mild stress. World Neurosurg 2020,139,e455-e462","journal-title":"World Neurosurg"},{"key":"ref=91","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fnbeh.2019.00019","volume":"13","author":"Selakovic D.","year":"2019","unstructured":"Selakovic D.; Joksimovic J.; Jovicic N.; The impact of hippocampal sex hormones receptors in modulation of depressive-like behavior following chronic anabolic androgenic steroids and exercise protocols in rats. Front Behav Neurosci 2019,13,19","journal-title":"Front Behav Neurosci"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1038\/npp.2017.76","volume":"42","author":"Dai D.","year":"2017","unstructured":"Dai D.; Li Q.C.; Zhu Q.B.; Direct involvement of androgen receptor in oxytocin gene expression: possible relevance for mood disorders. Neuropsychopharmacology 2017,42(10),2064-2071","journal-title":"Neuropsychopharmacology"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3389\/fncel.2019.00534","volume":"13","author":"Tozzi A.","year":"2019","unstructured":"Tozzi A.; Durante V.; Manca P.; Bidirectional synaptic plasticity is driven by sex neurosteroids targeting estrogen and androgen receptors in hippocampal CA1 pyramidal neurons. Front Cell Neurosci 2019,13,534","journal-title":"Front Cell Neurosci"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1080\/07853890.2018.1509118","volume":"50","author":"Haljas K.","year":"2018","unstructured":"Haljas K.; Lahti J.; Tuomi T.; Melatonin receptor 1B gene rs10830963 polymorphism, depressive symptoms and glycaemic traits. Ann Med 2018,50(8),704-712","journal-title":"Ann Med"},{"key":"ref=95","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.2174\/1381612824666180803112304","volume":"24","author":"Satyanarayanan S.K.","year":"2018","unstructured":"Satyanarayanan S.K.; Su H.; Lin Y.W.; Su K.P.; Circadian rhythm and melatonin in the treatment of depression. Curr Pharm Des 2018,24(22),2549-2555","journal-title":"Curr Pharm Des"},{"key":"ref=96","first-page":"1262","volume":"50","author":"Varma A.","year":"2002","unstructured":"Varma A.; Kaul R.K.; Varma P.; Kalra V.; Malhotra V.; The effect of antidepressants on serum melatonin levels in endogenous depression. J Assoc Physicians India 2002,50,1262-1265","journal-title":"J Assoc Physicians India"},{"key":"ref=97","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1080\/15622970600571822","volume":"7","author":"Srinivasan V.","year":"2006","unstructured":"Srinivasan V.; Smits M.; Spence W.; Melatonin in mood disorders. World J Biol Psychiatry 2006,7(3),138-151","journal-title":"World J Biol Psychiatry"},{"key":"ref=98","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s10549-014-2962-2","volume":"145","author":"Hansen M.V.","year":"2014","unstructured":"Hansen M.V.; Andersen L.T.; Madsen M.T.; Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: A randomized, double-blind, placebo-controlled trial. Breast Cancer Res Treat 2014,145(3),683-695","journal-title":"Breast Cancer Res Treat"},{"key":"ref=99","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1007\/s00429-015-1153-1","volume":"221","author":"Narv\u00e1ez M.","year":"2016","unstructured":"Narv\u00e1ez M.; Borroto-Escuela D.O.; Mill\u00f3n C.; Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects. Brain Struct Funct 2016,221(8),4129-4139","journal-title":"Brain Struct Funct"},{"key":"ref=100","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.npep.2017.01.004","volume":"64","author":"Mill\u00f3n C.","year":"2017","unstructured":"Mill\u00f3n C.; Flores-Burgess A.; Narv\u00e1ez M.; The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours. Neuropeptides 2017,64,39-45","journal-title":"Neuropeptides"},{"key":"ref=101","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12888-018-1850-4","volume":"18","author":"Lam D.","year":"2018","unstructured":"Lam D.; Ancelin M.L.; Ritchie K.; Freak-Poli R.; Saffery R.; Ryan J.; Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression. BMC Psychiatry 2018,18(1),282","journal-title":"BMC Psychiatry"},{"key":"ref=102","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3389\/fnins.2013.00128","volume":"7","author":"McQuaid R.J.","year":"2013","unstructured":"McQuaid R.J.; McInnis O.A.; Stead J.D.; Matheson K.; Anisman H.; A paradoxical association of an oxytocin receptor gene polymorphism: Early-life adversity and vulnerability to depression. Front Neurosci 2013,7,128","journal-title":"Front Neurosci"},{"key":"ref=103","doi-asserted-by":"publisher","first-page":"7685","DOI":"10.1038\/s41598-019-44175-6","volume":"9","author":"Choi D.","year":"2019","unstructured":"Choi D.; Tsuchiya K.J.; Takei N.; Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems. Sci Rep 2019,9(1),7685","journal-title":"Sci Rep"},{"key":"ref=104","doi-asserted-by":"publisher","first-page":"21437","DOI":"10.1073\/pnas.0909579106","volume":"106","author":"Rodrigues S.M.","year":"2009","unstructured":"Rodrigues S.M.; Saslow L.R.; Garcia N.; John O.P.; Keltner D.; Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci USA 2009,106(50),21437-21441","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=105","doi-asserted-by":"publisher","first-page":"15118","DOI":"10.1073\/pnas.1113137108","volume":"108","author":"Saphire-Bernstein S.","year":"2011","unstructured":"Saphire-Bernstein S.; Way B.M.; Kim H.S.; Sherman D.K.; Taylor S.E.; Oxytocin Receptor Gene (OXTR) is related to psychological resources. Proc Natl Acad Sci USA 2011,108(37),15118-15122","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=106","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2298\/ABS181206057B","volume":"71","author":"Ba\u0161i\u0107 J.","year":"2019","unstructured":"Ba\u0161i\u0107 J.; Milo\u0161evi\u0107 V.; Stankovi\u0107 M.; The influence of rs53576 and rs2254298 oxytocin receptor gene polymorphisms on plasma oxytocin levels and measures of empathy. Arch Biol Sci 2019,71(1),159-165","journal-title":"Arch Biol Sci"},{"key":"ref=107","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1590\/0047-2085000000242","volume":"68","author":"Camara A.B.","year":"2019","unstructured":"Camara A.B.; Neural receptors and Alzheimer\u2019s disease: A systematic review of the literature on the families of receptors most associated with the disease, their functions and areas of expression. J Bras Psiquiatr 2019,68(3),159-174","journal-title":"J Bras Psiquiatr"},{"key":"ref=108","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1590\/0047-2085000000258","volume":"69","author":"Castro C.","year":"2020","unstructured":"Castro C.; Tavares E.; Camara A.; Nobre I.; Molecular regulation of circadian rhythm and psychiatric disorders: A systematic review. J Bras Psiquiatr 2020,69(1),57-72","journal-title":"J Bras Psiquiatr"},{"key":"ref=109","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1007\/s11011-018-0292-5","volume":"33","author":"Almasi A.","year":"2018","unstructured":"Almasi A.; Zarei M.; Raoufi S.; Influence of hippocampal GABAB receptor inhibition on memory in rats with acute \u03b2-amyloid toxicity. Metab Brain Dis 2018,33(6),1859-1867","journal-title":"Metab Brain Dis"},{"key":"ref=110","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.fct.2018.04.064","volume":"118","author":"Mirzaei F.","year":"2018","unstructured":"Mirzaei F.; Khazaei M.; Komaki A.; Amiri I.; Jalili C.; Virgin Coconut Oil (VCO) by normalizing NLRP3 inflammasome showed potential neuroprotective effects in Amyloid-\u03b2 induced toxicity and high-fat diet fed rat. Food Chem Toxicol 2018,118,68-83","journal-title":"Food Chem Toxicol"}],"container-title":["CNS &amp; Neurological Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/183773","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/183773\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/183773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T04:58:22Z","timestamp":1625201902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/183773\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,20]]},"references-count":110,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11,20]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871527319666200715102430","relation":{},"ISSN":["1871-5273"],"issn-type":[{"type":"print","value":"1871-5273"}],"subject":[],"published":{"date-parts":[[2020,11,20]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}