{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:46:22Z","timestamp":1787604382960,"version":"build-2736575974"},"reference-count":113,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CNSNDDT"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>End-stage renal disease (ESRD) is associated with fatigue and physio-somatic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>To delineate the associations between severity of fatigue and physio-somatic symptoms and glomerular filtration rate, inflammatory biomarkers, and Wnt\/catenin-pathway proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The Wnt-pathway related proteins \u03b2-catenin, Dickkopf-related protein 1 (DKK1), R-spondin-1, and sclerostin were measured by ELISA technique in 60 ESRD patients and 30 controls. The Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale was used to assess the severity of FF symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>ESRD is characterized by a significant increase in the total FF score, muscle tension, fatigue, sadness, sleep disorders, gastro-intestinal (GI) symptoms, and a flu-like malaise. The total-FF score was significantly correlated with serum levels of urea, creatinine, and copper (positively), and \u03b2-catenin, eGFR, hemoglobin, albumin, and zinc (inversely). The total-FF score was associated with the number of total dialysis and weekly dialysis sessions, and these dialysis characteristics were more important in predicting FF scores than eGFR measurements. Partial Least Squares analysis showed that the FF score comprised two factors that are differently associated with biomarkers: a) 43.0% of the variance in fatigue, GI symptoms, muscle tension, sadness, and insomnia is explained by hemoglobin, albumin, zinc, \u03b2-catenin, and R-spondin-1; and b) 22.3% of the variance in irritability, concentration and memory impairments by increased copper and cations\/chloride ratio, and male sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>ESRD patients show high levels of fatigue and physio-somatic symptoms, which are associated with hemodialysis and mediated by dialysis-induced changes in inflammatory pathways, the Wnt\/catenin pathway, and copper.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1871527321666220401140747","type":"journal-article","created":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T18:09:36Z","timestamp":1649009376000},"page":"191-206","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Causal-Pathway Phenotype of Chronic Fatigue Syndrome due to Hemodialysis in Patients with End-Stage Renal Disease"],"prefix":"10.2174","volume":"22","author":[{"given":"Michael","family":"Maes","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria"},{"name":"School of Medicine, IMPACT Strategic Research Centre, Deakin University, VIC, 3220, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halah Nori","family":"Asad","sequence":"additional","affiliation":[{"name":"Al Najaf Health Directorate, Higher Health Institute, Najaf, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein Kadhem","family":"Al-Hakeim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, University of Kufa, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shatha Rouf","family":"Moustafa","sequence":"additional","affiliation":[{"name":"Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1681\/ASN.2017070765","volume":"29","author":"Al-Jaghbeer M.","year":"2018","unstructured":"Al-Jaghbeer M.; Dealmeida D.; Bilderback A.; Ambrosino R.; Kellum J.A.; Clinical decision support for in-hospital AKI. J Am Soc Nephrol 2018,29(2),654-660","journal-title":"J Am Soc Nephrol"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.jped.2020.08.003","volume":"97","author":"Louzada C.F.","year":"2021","unstructured":"Louzada C.F.; Ferreira A.R.; Evaluation of the prevalence and factors associated with acute kidney injury in a pediatric intensive care unit. J Pediatr (Rio J) 2021,97(4),426-432","journal-title":"J Pediatr (Rio J)"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12882-017-0476-y","volume":"18","author":"Chew S.T.","year":"2017","unstructured":"Chew S.T.; Ng R.R.; Liu W.; Chow K.Y.; Ti L.K.; Acute kidney injury increases the risk of end-stage renal disease after cardiac surgery in an Asian population: A prospective cohort study. BMC Nephrol 2017,18(1),60","journal-title":"BMC Nephrol"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1681\/ASN.2007080837","volume":"20","author":"Ishani A.","year":"2009","unstructured":"Ishani A.; Xue J.L.; Himmelfarb J.; Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol 2009,20(1),223-228","journal-title":"J Am Soc Nephrol"},{"key":"ref=5","volume":"2010","author":"Abbasi M.A.","year":"2010","unstructured":"Abbasi M.A.; Chertow G.M.; Hall Y.N.; End-stage renal disease 2010,2010","journal-title":"End-stage renal disease"},{"key":"ref=6","year":"2020","unstructured":"USRDS USRDS 2020 USRDS Annual Data Report: Epidemiology of kidney disease in the United States 2020","journal-title":"USRDS USRDS 2020 USRDS Annual Data Report: Epidemiology of kidney disease in the United States"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"358","DOI":"10.5414\/CN106960","volume":"76","author":"Karakan S.","year":"2011","unstructured":"Karakan S.; Sezer S.; Ozdemir F.N.; Factors related to fatigue and subgroups of fatigue in patients with end-stage renal disease. Clin Nephrol 2011,76(5),358-364","journal-title":"Clin Nephrol"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jpainsymman.2011.08.005","volume":"44","author":"Afshar M.","year":"2012","unstructured":"Afshar M.; Rebollo-Mesa I.; Murphy E.; Murtagh F.E.; Mamode N.; Symptom burden and associated factors in renal transplant patients in the U.K. J Pain Symptom Manage 2012,44(2),229-238","journal-title":"J Pain Symptom Manage"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jpsychores.2017.01.009","volume":"94","author":"Yoong R.K.","year":"2017","unstructured":"Yoong R.K.; Mooppil N.; Khoo E.Y.; Prevalence and determinants of anxiety and depression in End Stage Renal Disease (ESRD). A comparison between ESRD patients with and without coexisting diabetes mellitus. J Psychosom Res 2017,94,68-72","journal-title":"J Psychosom Res"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1093\/ckj\/sfx057","volume":"10","author":"Brown S.A.","year":"2017","unstructured":"Brown S.A.; Tyrer F.C.; Clarke A.L.; Symptom burden in patients with chronic kidney disease not requiring renal replacement therapy. Clin Kidney J 2017,10(6),788-796","journal-title":"Clin Kidney J"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/j.1365-2702.2005.01409.x","volume":"16","author":"Lee B.O.","year":"2007","unstructured":"Lee B.O.; Lin C.C.; Chaboyer W.; Chiang C.L.; Hung C.C.; The fatigue experience of haemodialysis patients in Taiwan. J Clin Nurs 2007,16(2),407-413","journal-title":"J Clin Nurs"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/17512433.2019.1555468","volume":"12","author":"Hamed S.A.","year":"2019","unstructured":"Hamed S.A.; Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: Presentations, causes, and treatment strategies. Expert Rev Clin Pharmacol 2019,12(1),61-90","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/B978-0-12-407710-2.00016-3","author":"Aminoff M.J.","year":"2014","unstructured":"Aminoff M.J.; Neurologic dysfunction and kidney disease. Aminoff\u2019s Neurology and General Medicine 2014,293-316","journal-title":"Aminoff\u2019s Neurology and General Medicine"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/ki.2014.86","volume":"86","author":"Artom M.","year":"2014","unstructured":"Artom M.; Moss-Morris R.; Caskey F.; Chilcot J.; Fatigue in advanced kidney disease. Kidney Int 2014,86(3),497-505","journal-title":"Kidney Int"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1053\/j.ajkd.2016.11.029","volume":"70","author":"Evangelidis N.","year":"2017","unstructured":"Evangelidis N.; Tong A.; Manns B.; Developing a set of core outcomes for trials in hemodialysis: An international delphi survey. Am J Kidney Dis 2017,70(4),464-475","journal-title":"Am J Kidney Dis"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"735","DOI":"10.2215\/CJN.10850917","volume":"13","author":"Flythe J.E.","year":"2018","unstructured":"Flythe J.E.; Hilliard T.; Castillo G.; Symptom prioritization among adults receiving in-center hemodialysis: A mixed methods study. Clin J Am Soc Nephrol 2018,13(5),735-745","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1053\/j.ajkd.2017.01.051","volume":"69","author":"Roshanravan B.","year":"2017","unstructured":"Roshanravan B.; Gamboa J.; Wilund K.; Exercise and CKD: Skeletal muscle dysfunction and practical application of exercise to prevent and treat physical impairments in CKD. Am J Kidney Dis 2017,69(6),837-852","journal-title":"Am J Kidney Dis"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1741-7015-8-35","volume":"8","author":"Maes M.","year":"2010","unstructured":"Maes M.; Twisk F.N.; Chronic fatigue syndrome: Harvey and Wessely\u2019s (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. BMC Med 2010,8(1),35","journal-title":"BMC Med"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jad.2013.03.029","volume":"150","author":"Maes M.","year":"2013","unstructured":"Maes M.; Ringel K.; Kubera M.; In myalgic encephalomyelitis\/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation. J Affect Disord 2013,150(2),223-230","journal-title":"J Affect Disord"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3390\/ijms21010263","volume":"21","author":"Rapa S.F.","year":"2019","unstructured":"Rapa S.F.; Di Iorio B.R.; Campiglia P.; Heidland A.; Marzocco S.; Inflammation and oxidative stress in chronic kidney disease-potential therapeutic role of minerals, vitamins and plant-derived metabolites. Int J Mol Sci 2019,21(1),263","journal-title":"Int J Mol Sci"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"155369","DOI":"10.1016\/j.cyto.2020.155369","volume":"138","author":"Oweis A.O.","year":"2021","unstructured":"Oweis A.O.; Al-Qarqaz F.; Bodoor K.; Elevated interleukin 31 serum levels in hemodialysis patients are associated with uremic pruritus. Cytokine 2021,138,155369","journal-title":"Cytokine"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"e24275","DOI":"10.1097\/MD.0000000000024275","volume":"100","author":"Chen L.","year":"2021","unstructured":"Chen L.; Chen G.; Kong X.; Serum level of high mobility group box protein-1 and prognosis of patients with end-stage renal disease on hemodialysis and peritoneal dialysis. Medicine (Baltimore) 2021,100(5),e24275","journal-title":"Medicine (Baltimore)"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/hdi.12849","volume":"24","author":"Malekmakan L.","year":"2020","unstructured":"Malekmakan L.; Karimi Z.; Mansourian A.; Pakfetrat M.; Roozbeh J.; Rahimi Jaberi K.; Role of vitamin D in oxidative stress modulation in end-stage renal disease patients: A double-blind randomized clinical trial. Hemodial Int 2020,24(3),367-373","journal-title":"Hemodial Int"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s12882-020-01937-z","volume":"21","author":"Song Y.R.","year":"2020","unstructured":"Song Y.R.; Kim J.K.; Lee H.S.; Kim S.G.; Choi E.K.; Serum levels of protein carbonyl, a marker of oxidative stress, are associated with overhydration, sarcopenia and mortality in hemodialysis patients. BMC Nephrol 2020,21(1),281","journal-title":"BMC Nephrol"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"126580","DOI":"10.1016\/j.jtemb.2020.126580","volume":"62","author":"Almeida A.","year":"2020","unstructured":"Almeida A.; Gajewska K.; Duro M.; Costa F.; Pinto E.; Trace element imbalances in patients undergoing chronic hemodialysis therapy - Report of an observational study in a cohort of Portuguese patients. J Trace Elem Med Biol 2020,62,126580","journal-title":"J Trace Elem Med Biol"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/ndt\/16.2.335","volume":"16","author":"Nguyen-Khoa T.","year":"2001","unstructured":"Nguyen-Khoa T.; Massy Z.A.; De Bandt J.P.; Oxidative stress and haemodialysis: Role of inflammation and duration of dialysis treatment. Nephrol Dial Transplant 2001,16(2),335-340","journal-title":"Nephrol Dial Transplant"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"8567275","DOI":"10.1155\/2019\/8567275","volume":"2019","author":"Russa D.","year":"2019","unstructured":"Russa D.; Pellegrino D.; Montesanto A.; Oxidative balance and inflammation in hemodialysis patients: Biomarkers of cardiovascular risk? Oxid Med Cell Longev 2019,2019,8567275","journal-title":"Oxid Med Cell Longev"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"BC12","DOI":"10.7860\/JCDR\/2015\/14928.6697","volume":"9","author":"Vijayalakshmi U.B.","year":"2015","unstructured":"Vijayalakshmi U.B.; Rayidi M.; Laboratory profiles of patients on hemodialysis - A retrospective one year study in a rural tertiary care hospital. J Clin Diagn Res 2015,9(10),BC12-BC15","journal-title":"J Clin Diagn Res"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"725","DOI":"10.3390\/ijms21030725","volume":"21","year":"2020","unstructured":"Gluba-Brz&#x64E;zka A, Franczyk B, Olszewski R, Rysz J. The influence of inflammation on anemia in CKD patients. Int J Mol Sci 2020,21(3),725","journal-title":"Int J Mol Sci"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1093\/ndt\/gfx191","volume":"33","author":"van Gelder M.K.","year":"2018","unstructured":"van Gelder M.K.; Abrahams A.C.; Joles J.A.; Kaysen G.A.; Gerritsen K.G.F.; Albumin handling in different hemodialysis modalities. Nephrol Dial Transplant 2018,33(6),906-913","journal-title":"Nephrol Dial Transplant"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/S0272-6386(03)00653-X","volume":"42","author":"Danielski M.","year":"2003","unstructured":"Danielski M.; Ikizler T.A.; McMonagle E.; Linkage of hypoalbuminemia, inflammation, and oxidative stress in patients receiving maintenance hemodialysis therapy. Am J Kidney Dis 2003,42(2),286-294","journal-title":"Am J Kidney Dis"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"E577","DOI":"10.3390\/nu12020577","volume":"12","author":"Nishime K.","year":"2020","unstructured":"Nishime K.; Kondo M.; Saito K.; Miyawaki H.; Nakagawa T.; Zinc burden evokes copper deficiency in the hypoalbuminemic hemodialysis patients. Nutrients 2020,12(2),E577","journal-title":"Nutrients"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1681\/ASN.2004070602","volume":"16","author":"Kestenbaum B.","year":"2005","unstructured":"Kestenbaum B.; Sampson J.N.; Rudser K.D.; Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 2005,16(2),520-528","journal-title":"J Am Soc Nephrol"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1001\/archinternmed.2009.132","volume":"169","author":"Einhorn L.M.","year":"2009","unstructured":"Einhorn L.M.; Zhan M.; Hsu V.D.; The frequency of hyperkalemia and its significance in chronic kidney disease. Arch Intern Med 2009,169(12),1156-1162","journal-title":"Arch Intern Med"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/ki.2008.151","volume":"74","author":"Barbour S.J.","year":"2008","unstructured":"Barbour S.J.; Er L.; Djurdjev O.; Karim M.A.; Levin A.; The prevalence of hematologic and metabolic abnormalities during chronic kidney disease stages in different ethnic groups. Kidney Int 2008,74(1),108-114","journal-title":"Kidney Int"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"168","DOI":"10.2174\/1570159X11666131120224653","volume":"12","author":"Morris G.","year":"2014","unstructured":"Morris G.; Maes M.; Oxidative and nitrosative stress and immune-inflammatory pathways in patients with Myalgic Encephalomyelitis (ME)\/Chronic Fatigue Syndrome (CFS). Curr Neuropharmacol 2014,12(2),168-185","journal-title":"Curr Neuropharmacol"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S0022-3999(01)00315-4","volume":"52","author":"Zachrisson O.","year":"2002","unstructured":"Zachrisson O.; Regland B.; Jahreskog M.; Kron M.; Gottfries C.G.; A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale). J Psychosom Res 2002,52(6),501-509","journal-title":"J Psychosom Res"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.2174\/1568026621666210727170147","volume":"21","author":"Maes M.","year":"2021","unstructured":"Maes M.; Kubera M.; Stoyanova K.; Leunis J.C.; The reification of the clinical diagnosis of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) as an immune and oxidative stress disorder: Construction of a data-driven nomothethic network and exposure of ME\/CFS subgroups. Curr Top Med Chem 2021,21(16),1488-1499","journal-title":"Curr Top Med Chem"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/1741-7015-11-205","volume":"11","author":"Morris G.","year":"2013","unstructured":"Morris G.; Maes M.; Myalgic encephalomyelitis\/chronic fatigue syndrome and encephalomyelitis disseminata\/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics. BMC Med 2013,11(1),205","journal-title":"BMC Med"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1007\/s12035-015-9090-9","volume":"53","author":"Morris G.","year":"2016","unstructured":"Morris G.; Berk M.; Galecki P.; Walder K.; Maes M.; The neuro-immune pathophysiology of central and peripheral fatigue in systemic immune-inflammatory and neuro-immune diseases. Mol Neurobiol 2016,53(2),1195-1219","journal-title":"Mol Neurobiol"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/path.4121","volume":"229","author":"Kawakami T.","year":"2013","unstructured":"Kawakami T.; Ren S.; Duffield J.S.; Wnt signalling in kidney diseases: Dual roles in renal injury and repair. J Pathol 2013,229(2),221-231","journal-title":"J Pathol"},{"key":"ref=42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biocel.2016.05.015","volume":"77","author":"Duan P","year":"2016","unstructured":"Duan P; Bonewald L F; The role of the wnt\/&#x3B2;-catenin signaling pathway in formation and maintenance of bone and teeth. Int J Biochem Cell Biol 2016,77(Pt A),23-9","journal-title":"Int J Biochem Cell Biol"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/bs.pmbts.2017.11.019","volume":"153","author":"Wang Y.","year":"2018","unstructured":"Wang Y.; Zhou C.J.; Liu Y.; Wnt signaling in kidney development and disease. Prog Mol Biol Transl Sci 2018,153,181-207","journal-title":"Prog Mol Biol Transl Sci"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/35083081","volume":"3","author":"Bafico A.","year":"2001","unstructured":"Bafico A.; Liu G.; Yaniv A.; Gazit A.; Aaronson S.A.; Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6\/Arrow. Nat Cell Biol 2001,3(7),683-686","journal-title":"Nat Cell Biol"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"5570","DOI":"10.1038\/s41467-020-19373-w","volume":"11","author":"Lee H.","year":"2020","unstructured":"Lee H.; Seidl C.; Sun R.; Glinka A.; Niehrs C.; R-spondins are BMP receptor antagonists in Xenopus early embryonic development. Nat Commun 2020,11(1),5570","journal-title":"Nat Commun"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"14700","DOI":"10.1073\/pnas.0702305104","volume":"104","author":"Binnerts M.E.","year":"2007","unstructured":"Binnerts M.E.; Kim K.A.; Bright J.M.; R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci USA 2007,104(37),14700-14705","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1126\/science.1094291","volume":"303","author":"Nelson W.J.","year":"2004","unstructured":"Nelson W.J.; Nusse R.; Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004,303(5663),1483-1487","journal-title":"Science"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.diff.2019.05.003","volume":"108","author":"Chae W.J.","year":"2019","unstructured":"Chae W.J.; Bothwell A.L.M.; Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation. Differentiation 2019,108,33-39","journal-title":"Differentiation"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.nbd.2006.06.016","volume":"24","author":"Scali C.","year":"2006","unstructured":"Scali C.; Caraci F.; Gianfriddo M.; Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1. Neurobiol Dis 2006,24(2),254-265","journal-title":"Neurobiol Dis"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3389\/fncel.2013.00162","volume":"7","author":"Dickins E.M.","year":"2013","unstructured":"Dickins E.M.; Salinas P.C.; Wnts in action: From synapse formation to synaptic maintenance. Front Cell Neurosci 2013,7,162","journal-title":"Front Cell Neurosci"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1111\/jnc.12492","volume":"128","author":"Orellana J.A.","year":"2014","unstructured":"Orellana J.A.; S&#xE1;ez JC, Bennett MV, Berman JW, Morgello S, Eugenin EA. HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel-dependent mechanism. J Neurochem 2014,128(5),752-763","journal-title":"J Neurochem"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.stem.2012.11.010","volume":"12","author":"Seib D.R.","year":"2013","unstructured":"Seib D.R.; Corsini N.S.; Ellwanger K.; Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline. Cell Stem Cell 2013,12(2),204-214","journal-title":"Cell Stem Cell"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1093\/gerona\/glx252","volume":"73","author":"Ross R.D.","year":"2018","unstructured":"Ross R.D.; Shah R.C.; Leurgans S.; Bottiglieri T.; Wilson R.S.; Sumner D.R.; Circulating Dkk1 and TRAIL are associated with cognitive decline in community-dwelling, older adults with cognitive concerns. J Gerontol A Biol Sci Med Sci 2018,73(12),1688-1694","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.neuroscience.2019.06.038","volume":"415","author":"Wang G.","year":"2019","unstructured":"Wang G.; Li Z.; Li S.; Minocycline preserves the integrity and permeability of BBB by altering the activity of DKK1-Wnt signaling in ICH model. Neuroscience 2019,415,135-146","journal-title":"Neuroscience"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/jcbfm.2013.213","volume":"34","author":"Artus C.","year":"2014","unstructured":"Artus C.; Glacial F.; Ganeshamoorthy K.; The Wnt\/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells. J Cereb Blood Flow Metab 2014,34(3),433-440","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"7133","DOI":"10.4238\/2014.April.3.4","volume":"13","author":"Liu H.C.","year":"2014","unstructured":"Liu H.C.; Zhang J.; Wong S.; Han D.; Zhao H.S.; Feng H.L.; Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population. Genet Mol Res 2014,13(3),7133-7139","journal-title":"Genet Mol Res"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.pnpbp.2012.10.022","volume":"48","author":"Na K.S.","year":"2014","unstructured":"Na K.S.; Jung H.Y.; Kim Y.K.; The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2014,48,277-286","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s11011-020-00619-x","volume":"36","author":"Mousa R.F.","year":"2021","unstructured":"Mousa R.F.; Al-Hakeim H.K.; Alhaideri A.; Maes M.; Chronic fatigue syndrome and fibromyalgia-like symptoms are an integral component of the phenome of schizophrenia: Neuro-immune and opioid system correlates. Metab Brain Dis 2021,36(1),169-183","journal-title":"Metab Brain Dis"},{"key":"ref=59","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/schbul\/sbaa136","volume":"47","author":"Al-Dujaili A.H.","year":"2021","unstructured":"Al-Dujaili A.H.; Mousa R.F.; Al-Hakeim H.K.; Maes M.; High mobility group protein 1 and dickkopf-related protein 1 in schizophrenia and treatment-resistant schizophrenia: Associations with interleukin-6, symptom domains, and neurocognitive impairments. Schizophr Bull 2021,47(2),530-541","journal-title":"Schizophr Bull"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","volume":"158","author":"Stevens P.E.","year":"2013","unstructured":"Stevens P.E.; Levin A.; Evaluation and management of chronic kidney disease: Synopsis of the kidney disease: Improving global outcomes 2012 clinical practice guideline. Ann Intern Med 2013,158(11),825-830","journal-title":"Ann Intern Med"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s12640-018-9868-4","volume":"33","author":"Kanchanatawan B.","year":"2018","unstructured":"Kanchanatawan B.; Thika S.; Sirivichayakul S.; Carvalho A.F.; Geffard M.; Maes M.; In schizophrenia, depression, anxiety, and physiosomatic symptoms are strongly related to psychotic symptoms and excitation, impairments in episodic memory, and increased production of neurotoxic tryptophan catabolites: A multivariate and machine learning study. Neurotox Res 2018,33(3),641-655","journal-title":"Neurotox Res"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1373\/clinchem.2006.077180","volume":"53","author":"Levey A.S.","year":"2007","unstructured":"Levey A.S.; Coresh J.; Greene T.; Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values. Clin Chem 2007,53(4),766-772","journal-title":"Clin Chem"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1080\/10705511.2020.1735393","volume":"28","author":"Lorenzo-Seva U.","year":"2020","unstructured":"Lorenzo-Seva U.; Ferrando P.J.; Not positive definite correlation matrices in exploratory item factor analysis: Causes, consequences and a proposed solution. Struct Equ Modeling 2020,28(1),138-147","journal-title":"Struct Equ Modeling"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1177\/0013164417719308","volume":"78","author":"Ferrando P.J.","year":"2018","unstructured":"Ferrando P.J.; Lorenzo-Seva U.; Assessing the quality and appropriateness of factor solutions and factor score estimates in exploratory item factor analysis. Educ Psychol Meas 2018,78(5),762-780","journal-title":"Educ Psychol Meas"},{"key":"ref=65","author":"Ringle, C.M.","unstructured":"Ringle, C.M. ; Wende, S. ; Becker, J.M ; (2015) SmartPLS 3. SmartPLS GmbH, Boenningstedt. http:\/\/www.smartpls.com"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.comppsych.2019.01.003","volume":"90","author":"Luo Y.","year":"2019","unstructured":"Luo Y.; He H.; Zhang J.; Ou Y.; Fan N.; Changes in serum TNF-&#x3B1; IL-18, and IL-6 concentrations in patients with chronic schizophrenia at admission and at discharge. Compr Psychiatry 2019,90,82-87","journal-title":"Compr Psychiatry"},{"key":"ref=67","first-page":"113","volume":"40","author":"Horigan A.E.","year":"2013","unstructured":"Horigan A.E.; Schneider S.M.; Docherty S.; Barroso J.; The experience and self-management of fatigue in patients on hemodialysis. Nephrol Nurs J 2013,40(2),113-122","journal-title":"Nephrol Nurs J"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/tri.12727","volume":"29","author":"Chan W.","year":"2016","unstructured":"Chan W.; Jones D.; Bosch J.A.; Cardiovascular, muscular and perceptual contributions to physical fatigue in prevalent kidney transplant recipients. Transpl Int 2016,29(3),338-351","journal-title":"Transpl Int"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.2215\/CJN.00190109","volume":"4","author":"Jhamb M.","year":"2009","unstructured":"Jhamb M.; Argyropoulos C.; Steel J.L.; Correlates and outcomes of fatigue among incident dialysis patients. Clin J Am Soc Nephrol 2009,4(11),1779-1786","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.2215\/CJN.01610214","volume":"9","author":"Manns B.","year":"2014","unstructured":"Manns B.; Hemmelgarn B.; Lillie E.; Setting research priorities for patients on or nearing dialysis. Clin J Am Soc Nephrol 2014,9(10),1813-1821","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.jpainsymman.2011.10.015","volume":"44","author":"Horigan A.E.","year":"2012","unstructured":"Horigan A.E.; Fatigue in hemodialysis patients: A review of current knowledge. J Pain Symptom Manage 2012,44(5),715-724","journal-title":"J Pain Symptom Manage"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"376","DOI":"10.5455\/medarh.2015.69.376-380","volume":"69","author":"Zyga S.","year":"2015","unstructured":"Zyga S.; Alikari V.; Sachlas A.; Assessment of fatigue in end stage renal disease patients undergoing hemodialysis: Prevalence and associated factors. Med Arh 2015,69(6),376-380","journal-title":"Med Arh"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/pri.287","volume":"8","author":"Heiwe S.","year":"2003","unstructured":"Heiwe S.; Clyne N.; Dahlgren M.A.; Living with chronic renal failure: Patients\u2019 experiences of their physical and functional capacity. Physiother Res Int 2003,8(4),167-177","journal-title":"Physiother Res Int"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000231985","volume":"28","author":"Bossola M.","year":"2009","unstructured":"Bossola M.; Luciani G.; Tazza L.; Fatigue and its correlates in chronic hemodialysis patients. Blood Purif 2009,28(3),245-252","journal-title":"Blood Purif"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.jpainsymman.2016.10.365","volume":"53","author":"Farragher J.F.","year":"2017","unstructured":"Farragher J.F.; Polatajko H.J.; Jassal S.V.; The relationship between fatigue and depression in adults with end-stage renal disease on chronic in-hospital hemodialysis: A scoping review. J Pain Symptom Manage 2017,53(4),783-803","journal-title":"J Pain Symptom Manage"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1053\/j.ajkd.2019.01.034","volume":"74","author":"Jacobson J.","year":"2019","unstructured":"Jacobson J.; Ju A.; Baumgart A.; Patient perspectives on the meaning and impact of fatigue in hemodialysis: A systematic review and thematic analysis of qualitative studies. Am J Kidney Dis 2019,74(2),179-192","journal-title":"Am J Kidney Dis"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.nefro.2016.03.024","volume":"36","author":"Caravaca F.","year":"2016","unstructured":"Caravaca F.; Gonzales B.; Bayo M.&#xC1;,; Luna E.; Musculoskeletal pain in patients with chronic kidney disease. Nefrologia 2016,36(4),433-440","journal-title":"Nefrologia"},{"key":"ref=78","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1159\/000336803","volume":"81","author":"Maes M.","year":"2012","unstructured":"Maes M.; Twisk F.N.; Ringel K.; Inflammatory and cell-mediated immune biomarkers in myalgic encephalomyelitis\/chronic fatigue syndrome and depression: Inflammatory markers are higher in myalgic encephalomyelitis\/chronic fatigue syndrome than in depression. Psychother Psychosom 2012,81(5),286-295","journal-title":"Psychother Psychosom"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s11011-019-00506-0","volume":"35","author":"Al-Hakeim H.K.","year":"2020","unstructured":"Al-Hakeim H.K.; Al-Issa A.A.R.; Maes M.; Serum agrin and talin are increased in major depression while agrin and creatine phosphokinase are associated with chronic fatigue and fibromyalgia symptoms in depression. Metab Brain Dis 2020,35(1),225-235","journal-title":"Metab Brain Dis"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.jad.2021.03.062","volume":"287","author":"Almulla A.F.","year":"2021","unstructured":"Almulla A.F.; Al-Rawi K.F.; Maes M.; Al-Hakeim H.K.; In schizophrenia, immune-inflammatory pathways are strongly associated with depressive and anxiety symptoms, which are part of a latent trait which comprises neurocognitive impairments and schizophrenia symptoms. J Affect Disord 2021,287,316-326","journal-title":"J Affect Disord"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/j.1365-2702.2006.01349.x","volume":"15","author":"Morsch C.M.","year":"2006","unstructured":"Morsch C.M.; Gon&#xE7;alves L.F.; Barros E.; Health-related quality of life among haemodialysis patients--relationship with clinical indicators, morbidity and mortality. J Clin Nurs 2006,15(4),498-504","journal-title":"J Clin Nurs"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/j.1365-2702.2007.01965.x","volume":"16","author":"O\u2019Sullivan D.","year":"2007","unstructured":"O\u2019Sullivan D.; McCarthy G.; An exploration of the relationship between fatigue and physical functioning in patients with end stage renal disease receiving haemodialysis. J Clin Nurs 2007,16(11C),276-284","journal-title":"J Clin Nurs"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1442-2018.2011.00579.x","volume":"13","author":"Letchmi S.","year":"2011","unstructured":"Letchmi S.; Das S.; Halim H.; Fatigue experienced by patients receiving maintenance dialysis in hemodialysis units. Nurs Health Sci 2011,13(1),60-64","journal-title":"Nurs Health Sci"},{"key":"ref=84","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1053\/j.ajkd.2012.11.047","volume":"61","author":"Unruh M.L.","year":"2013","unstructured":"Unruh M.L.; Larive B.; Chertow G.M.; Effects of 6-times-weekly versus 3-times-weekly hemodialysis on depressive symptoms and self-reported mental health: Frequent Hemodialysis Network (FHN) Trials. Am J Kidney Dis 2013,61(5),748-758","journal-title":"Am J Kidney Dis"},{"key":"ref=85","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.kint.2016.10.033","volume":"91","author":"Garg A.X.","year":"2017","unstructured":"Garg A.X.; Suri R.S.; Eggers P.; Patients receiving frequent hemodialysis have better health-related quality of life compared to patients receiving conventional hemodialysis. Kidney Int 2017,91(3),746-754","journal-title":"Kidney Int"},{"key":"ref=86","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/nhs.12008","volume":"15","author":"Karadag E.","year":"2013","unstructured":"Karadag E.; Kilic S.P.; Metin O.; Relationship between fatigue and social support in hemodialysis patients. Nurs Health Sci 2013,15(2),164-171","journal-title":"Nurs Health Sci"},{"key":"ref=87","first-page":"222","author":"Bossola M.","year":"2016","unstructured":"Bossola M.; Tazza L.; Postdialysis fatigue: A frequent and debilitating symptom, Semin Dial 2016,222-227","journal-title":"Postdialysis fatigue: A frequent and debilitating symptom, Semin Dial"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1159\/000328004","volume":"33","author":"Jhamb M.","year":"2011","unstructured":"Jhamb M.; Pike F.; Ramer S.; Impact of fatigue on outcomes in the hemodialysis (HEMO) study. Am J Nephrol 2011,33(6),515-523","journal-title":"Am J Nephrol"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1097\/TP.0b013e3182a2e88b","volume":"96","author":"Chan W.","year":"2013","unstructured":"Chan W.; Bosch J.A.; Jones D.; Predictors and consequences of fatigue in prevalent kidney transplant recipients. Transplantation 2013,96(11),987-994","journal-title":"Transplantation"},{"key":"ref=90","doi-asserted-by":"publisher","first-page":"687","DOI":"10.2215\/CJN.01650216","volume":"12","author":"Cabrera V.J.","year":"2017","unstructured":"Cabrera V.J.; Hansson J.; Kliger A.S.; Finkelstein F.O.; Symptom management of the patient with CKD: The role of dialysis. Clin J Am Soc Nephrol 2017,12(4),687-693","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref=91","doi-asserted-by":"publisher","first-page":"e1818","DOI":"10.7717\/peerj.1818","volume":"4","author":"Chao C-T.","year":"2016","unstructured":"Chao C-T.; Huang J-W.; Chiang C-K.; Functional assessment of chronic illness therapy-the fatigue scale exhibits stronger associations with clinical parameters in chronic dialysis patients compared to other fatigue-assessing instruments. PeerJ 2016,4,e1818","journal-title":"PeerJ"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1152\/physiologyonline.2002.17.1.17","volume":"17","author":"Westerblad H.","year":"2002","unstructured":"Westerblad H.; Allen D.G.; L&#xE4;nnergren J. Muscle fatigue: Lactic acid or inorganic phosphate the major cause? News Physiol Sci 2002,17(1),17-21","journal-title":"News Physiol Sci"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1038\/s41598-018-21784-1","volume":"8","author":"Chen Y.Y.","year":"2018","unstructured":"Chen Y.Y.; Kao T.W.; Chou C.W.; Exploring the link between serum phosphate levels and low muscle strength, dynapenia, and sarcopenia. Sci Rep 2018,8(1),3573","journal-title":"Sci Rep"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2369-15-6","volume":"15","author":"Hsu H.J.","year":"2014","unstructured":"Hsu H.J.; Yen C.H.; Hsu K.H.; Factors associated with chronic musculoskeletal pain in patients with chronic kidney disease. BMC Nephrol 2014,15(1),6","journal-title":"BMC Nephrol"},{"key":"ref=95","doi-asserted-by":"publisher","first-page":"iii35","DOI":"10.1093\/ndt\/gfy175","volume":"33","author":"Cobo G.","year":"2018","unstructured":"Cobo G.; Lindholm B.; Stenvinkel P.; Chronic inflammation in end-stage renal disease and dialysis. Nephrol Dial Transplant 2018,33(Suppl. 3),iii35-iii40","journal-title":"Nephrol Dial Transplant"},{"key":"ref=96","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1365-2702.2007.02042.x","volume":"17","author":"Bonner A.","year":"2008","unstructured":"Bonner A.; Wellard S.; Caltabiano M.; Levels of fatigue in people with ESRD living in far North Queensland. J Clin Nurs 2008,17(1),90-98","journal-title":"J Clin Nurs"},{"key":"ref=97","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2174\/157016107780368280","volume":"5","author":"Miller M.A.","year":"2007","unstructured":"Miller M.A.; Cappuccio F.P.; Inflammation, sleep, obesity and cardiovascular disease. Curr Vasc Pharmacol 2007,5(2),93-102","journal-title":"Curr Vasc Pharmacol"},{"key":"ref=98","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jad.2005.11.002","volume":"90","author":"Maes M.","year":"2006","unstructured":"Maes M.; Mihaylova I.; De Ruyter M.; Lower serum zinc in Chronic Fatigue Syndrome (CFS): Relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord 2006,90(2-3),141-147","journal-title":"J Affect Disord"},{"key":"ref=99","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1681\/ASN.V491711","volume":"4","author":"Zaoui P.","year":"1994","unstructured":"Zaoui P.; Hakim R.M.; The effects of the dialysis membrane on cytokine release. J Am Soc Nephrol 1994,4(9),1711-1718","journal-title":"J Am Soc Nephrol"},{"key":"ref=100","doi-asserted-by":"publisher","first-page":"797","DOI":"10.3233\/JAD-190114","volume":"71","author":"Supasitthumrong T.","year":"2019","unstructured":"Supasitthumrong T.; Tunvirachaisakul C.; Aniwattanapong D.; Peripheral blood biomarkers coupled with the apolipoprotein e4 genotype are strongly associated with semantic and episodic memory impairments in elderly subjects with amnestic mild cognitive impairment and Alzheimer\u2019s disease. J Alzheimers Dis 2019,71(3),797-811","journal-title":"J Alzheimers Dis"},{"key":"ref=101","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.psychres.2017.12.046","volume":"261","author":"Potharajaroen S.","year":"2018","unstructured":"Potharajaroen S.; Tangwongchai S.; Tayjasanant T.; Thawitsri T.; Anderson G.; Maes M.; Bright light and oxygen therapies decrease delirium risk in critically ill surgical patients by targeting sleep and acid-base disturbances. Psychiatry Res 2018,261,21-27","journal-title":"Psychiatry Res"},{"key":"ref=102","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","volume":"149","author":"Clevers H.","year":"2012","unstructured":"Clevers H.; Nusse R.; Wnt\/&#x3B2;-catenin signaling and disease. Cell 2012,149(6),1192-1205","journal-title":"Cell"},{"key":"ref=103","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/embor.2011.175","volume":"12","author":"Glinka A.","year":"2011","unstructured":"Glinka A.; Dolde C.; Kirsch N.; LGR4 and LGR5 are R-spondin receptors mediating Wnt\/&#x3B2;-catenin and Wnt\/PCP signalling. EMBO Rep 2011,12(10),1055-1061","journal-title":"EMBO Rep"},{"key":"ref=104","doi-asserted-by":"crossref","first-page":"1248012","DOI":"10.1126\/science.1248012","volume":"346","author":"Clevers H.","year":"2014","unstructured":"Clevers H.; Loh K.M.; Nusse R.; An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science 2014,346(6205),1248012","journal-title":"Science"},{"key":"ref=105","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jdsr.2019.03.001","volume":"55","author":"Nagano K.","year":"2019","unstructured":"Nagano K.; R-spondin signaling as a pivotal regulator of tissue development and homeostasis. Jpn Dent Sci Rev 2019,55(1),80-87","journal-title":"Jpn Dent Sci Rev"},{"key":"ref=106","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/j.1745-7270.2008.00440.x","volume":"40","author":"Chen X.","year":"2008","unstructured":"Chen X.; Yang J.; Evans P.M.; Liu C.; Wnt signaling: The good and the bad. Acta Biochim Biophys Sin (Shanghai) 2008,40(7),577-594","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"ref=107","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1097\/TA.0000000000000566","volume":"78","author":"Kuncewitch M.","year":"2015","unstructured":"Kuncewitch M.; Yang W.L.; Jacob A.; Stimulation of Wnt\/&#x3B2;-catenin signaling pathway with Wnt agonist reduces organ injury after hemorrhagic shock. J Trauma Acute Care Surg 2015,78(4),793-800","journal-title":"J Trauma Acute Care Surg"},{"key":"ref=108","doi-asserted-by":"publisher","first-page":"E826","DOI":"10.3390\/cells8080826","volume":"8","author":"Ng L.F.","year":"2019","unstructured":"Ng L.F.; Kaur P.; Bunnag N.; WNT signaling in disease. Cells 2019,8(8),E826","journal-title":"Cells"},{"key":"ref=109","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000487764","volume":"26","author":"Teo C.H.","year":"2018","unstructured":"Teo C.H.; Soga T.; Parhar I.S.; Brain beta-catenin signalling during stress and depression. Neurosignals 2018,26(1),31-42","journal-title":"Neurosignals"},{"key":"ref=110","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2174\/1871527319666200930095149","volume":"20","author":"Roomruangwong C.","year":"2021","unstructured":"Roomruangwong C.; Maes M.; Biomarker validation of a new case definition of Menstrual Cycle-Associated Syndrome (MCAS) opinion paper. CNS Neurol Disord Drug Targets 2021,20(2),105-111","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref=111","doi-asserted-by":"publisher","first-page":"110355","DOI":"10.1016\/j.jpsychores.2020.110355","volume":"142","author":"Roomruangwong C.","year":"2021","unstructured":"Roomruangwong C.; Sirivichayakul S.; Matsumoto A.K.; Menstruation distress is strongly associated with hormone-immune-metabolic biomarkers. J Psychosom Res 2021,142,110355","journal-title":"J Psychosom Res"},{"key":"ref=112","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1097\/00002508-200207000-00008","volume":"18","author":"Panerai A.E.","year":"2002","unstructured":"Panerai A.E.; Vecchiet J.; Panzeri P.; Peripheral blood mononuclear cell &#x3B2;-endorphin concentration is decreased in chronic fatigue syndrome and fibromyalgia but not in depression: Preliminary report. Clin J Pain 2002,18(4),270-273","journal-title":"Clin J Pain"},{"key":"ref=113","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.jad.2021.10.039","volume":"297","author":"Al-Jassas H.K.","year":"2022","unstructured":"Al-Jassas H.K.; Al-Hakeim H.K.; Maes M.; Intersections between pneumonia, lowered oxygen saturation percentage and immune activation mediate depression, anxiety, and chronic fatigue syndrome-like symptoms due to COVID-19: A nomothetic network approach. J Affect Disord 2022,297,233-245","journal-title":"J Affect Disord"}],"container-title":["CNS &amp; Neurological Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1871527321666220401140747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/202979\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1871527321666220401140747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T15:54:16Z","timestamp":1700409256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/202979\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":113,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871527321666220401140747","relation":{},"ISSN":["1871-5273"],"issn-type":[{"value":"1871-5273","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2021-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}