{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T22:24:55Z","timestamp":1774045495889,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"5","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2019,6,3]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Genetic variations of the FTO gene were associated with obesity and type 2\ndiabetes determinants in the European population, notably raised blood levels of insulin and glucose.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The aim of this study was to test the association of FTOrs17817449 with obesity\/BMI and\ntype 2 diabetes risk among obese Egyptian population.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p> In this case-control study, (PCR-RFLP assay) was used for genotyping\nFTOrs17817449polymorphism (SNP) in 120 obese children and 120 controls conducted from attendants\nof genetic &amp; endocrinology Unit and outpatient clinics, Pediatric Department, Faculty of Medicine,\nMenoufia University Hospitals. In combination with anthropometric measurements of obesity,\npredisposition to T2D risk was analyzed (fasting insulin, fasting glucose, insulin resistance).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Consanguinity was evident in 32.5% of cases. Positive family history of both obesity and T2D\nwas found to be significant statistically (p&lt;0.05). FTO rs17817449G allele was positively associated\nwith WC (Waist Circumference) (Mean \u00b1 SD 84.1 \u00b1 9. 3), raised BMI (Body Mass Index) (32.7 \u00b1 3.5),\nfasting glucose (114.1 \u00b1 12.8mg\/dl), fasting insulin (7.2 \u00b1 1.2\u00b5U\/ml) and insulin resistance (61.1% of\ncases) (p&lt;0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>The odds ratio of obesity was 1.75(95%CI 1.02-3.02) for GT and GG genotype. Fasting glucose and\nfasting insulin showed statistically significant risk for T2D in the obese group.\n<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Genetic variation in FTOrs17817449(G allele) was definitely associated with raised BMI,\nBMI z-score and fasting insulin, and lowered QUICKI values, that predicted the risk for type 2 diabetes\namong obese children harboring the mutant G allele.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530319666190101124751","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T02:00:32Z","timestamp":1546999232000},"page":"697-704","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Potential Implication of FTO rs17817449 Gene Polymorphism on BMI Mediated Risk For Type2 Diabetes Among Obese Egyptian Children And Adolescents"],"prefix":"10.2174","volume":"19","author":[{"given":"Naglaa Fathy","family":"Barseem","sequence":"first","affiliation":[{"name":"Pediatric Department, Faculty of Medicine, Menoufia University, Shebeen Elkom, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soheir S. Abou","family":"El Ella","sequence":"additional","affiliation":[{"name":"Pediatric Department, Faculty of Medicine, Menoufia University, Shebeen Elkom, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha A.","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Pediatric Department, Faculty of Medicine, Menoufia University, Shebeen Elkom, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha R.","family":"El-Nehrawy","sequence":"additional","affiliation":[{"name":"Pediatric Department, Faculty of Medicine, Menoufia University, Shebeen Elkom, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Endocrine, Metabolic &amp; Immune Disorders - Drug Targets"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/168691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T10:12:43Z","timestamp":1562062363000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/168691\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,3]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,6,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1871530319666190101124751","relation":{},"ISSN":["1871-5303"],"issn-type":[{"value":"1871-5303","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}