{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T19:30:48Z","timestamp":1772220648225,"version":"3.50.1"},"reference-count":27,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2020,3,24]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Serum electrolytes, Creatinine, and thyroid profile play an important role in\n131I treated patients of thyroid disorders.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objectives:<\/jats:title>\n<jats:p>To determine the effect of radioactive iodine (131I) on renal parameters, serum electrolytes\nand the correlation among TFT\u2019S, creatinine, and chloride levels before and after I131 treatment in\nthyroid disorders.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The study was performed on 55 patients of thyrotoxicosis with age ranging from 16-65 years\n(mean age= 41\u00b114years and BMI=24.8\u00b14.46). The significance of the differences between the results\nof 1st, 2nd, and 3rd-time serum analysis was assessed by paired Student's t-test. Association between\nparameters was assessed by Spearman correlation analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title> Results:<\/jats:title>\n<jats:p>40 patients were taking Carbimazole, and 15 were directly recommended for I131 therapy.\nStrongly significant variations were observed for TFT\u2019S (T3=0.012, T4 =0.017, and TSH=0. 001) during\nthe follow-up treatment. Before taking I131 (Serum analyzed at 1st time), there observed negative\ncorrelation of T3(r=-.46, p=0. 002) and TSH (r=-0.31, p=0.02) with creatinine, and positive correlation\nof TSH(r=0.29,p=0.02) with chloride. BMI was negatively correlated with potassium(r=-0.30, p=0.02).\nAt the 2nd time (after stopping the Carbimazole), no correlation results were observed. Two months\nafter oral administration of 131I, creatinine, and chloride level was significantly increased (p=0.000),\n(P=0. 03) respectively, but had no correlation with TFT\u2019S.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our findings suggest that patients with goiter (diffused or toxic) have association of TFT\u2019S\nand BMI with serum electrolytes and creatinine, 131I therapy is also associated with the increase in\ncreatinine and chloride levels of patients leading to kidney problems.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530319666190829163413","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T13:35:26Z","timestamp":1567172126000},"page":"419-424","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Monitoring and Evaluation of Thyroid Function Tests, Serum Electrolytes and Creatinine Levels Before and After 131I Therapy"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7082-2294","authenticated-orcid":true,"given":"Rubaida","family":"Mehmood","sequence":"first","affiliation":[{"name":"Diagnostics Labs and Nuclear Medicine Department, Multan Institute of Nuclear Medicine and Radiotherapy (MINAR), PAEC, Multan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed S.","family":"Khan","sequence":"additional","affiliation":[{"name":"Diagnostics Labs and Nuclear Medicine Department, Multan Institute of Nuclear Medicine and Radiotherapy (MINAR), PAEC, Multan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajid","family":"Hussain","sequence":"additional","affiliation":[{"name":"Diagnostics Labs and Nuclear Medicine Department, Multan Institute of Nuclear Medicine and Radiotherapy (MINAR), PAEC, Multan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhlaque","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Diagnostics Labs and Nuclear Medicine Department, Multan Institute of Nuclear Medicine and Radiotherapy (MINAR), PAEC, Multan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhatul-Ain","family":"Arshad","sequence":"additional","affiliation":[{"name":"Zoology Department, Women University Multan, Multan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubina","family":"Mukhtar","sequence":"additional","affiliation":[{"name":"Diagnostics Labs and Nuclear Medicine Department, Multan Institute of Nuclear Medicine and Radiotherapy (MINAR), PAEC, Multan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.1210\/jc.2003-031832","volume":"89","author":"Kester M.H.","year":"2004","unstructured":"Kester M.H.; Martinez de Mena R.; Obregon M.J.; Marinkovic D.; Howatson A.; Visser T.J.; Hume R.; Morreale de Escobar G.; Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas. 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