{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:33:59Z","timestamp":1766158439943,"version":"3.40.5"},"reference-count":38,"publisher":"Bentham Science Publishers Ltd.","issue":"7","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2020,9,9]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Hypersensitivity to nickel is a very common cause of allergic contact dermatitis\nsince this metal is largely present in industrial and consumer products as well as in some commonly\nconsumed foods, air, soil, and water. In nickel-sensitized individuals, a cell-mediated delayed hypersensitivity\nresponse results in contact to dermatitis due to mucous membranes coming in long-term\ncontact with nickel-containing objects. This process involves the generation of reactive oxidative species\nand lipid peroxidation-induced oxidative damage. Immunologically, the involvement of T helper\n(h)-1 and Th-2 cells, as well as the reduced function of T regulatory cells, are of importance. The toxicity,\nmutagenicity, and carcinogenicity of nickel are attributed to the generation of reactive oxygen species\nand induction of oxidative damage via lipid peroxidation, which results in DNA damage.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The aim of this research is to identify nutritionally actionable interventions that can intercept\nnickel-induced cell damage due to their antioxidant capacities.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Nutritional interventions may be used to modulate immune dysregulation, thereby intercepting\nnickel-induced cellular damage. Among these nutritional interventions are a low-nickel diet\nand an antioxidant-rich diet that is sufficient in iron needed to minimize nickel absorption. These dietary\napproaches not only reduce the likelihood of nickel toxicity by minimizing nickel exposure but\nalso help prevent oxidative damage by supplying the body with antioxidants that neutralize free radicals.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200122155804","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T07:17:50Z","timestamp":1579763870000},"page":"1010-1014","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mechanisms of Nickel-Induced Cell Damage in Allergic Contact Dermatitis and Nutritional Intervention Strategies"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-9478","authenticated-orcid":true,"given":"Dana","family":"Filatova","sequence":"first","affiliation":[{"name":"Department of Nutrition and Integrative Health, Maryland University of Integrative Health, Laurel, Maryland, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-7448","authenticated-orcid":true,"given":"Christine","family":"Cherpak","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Health, Maryland University of Integrative Health, Laurel, Maryland, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2310\/6620.2008.06069","volume":"19","author":"Jacob S.E.","year":"2008","unstructured":"Jacob S.E.; Zapolanski T.; Systemic contact dermatitis. 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