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By the end of the experiment, serum\nblood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB), cardiac histopathology, oxidative\nstress markers (MDA, GSH and CAT), myocardial fibrosis by Masson trichrome, the expression\nof p53, caspase-3, \u03b1-SMA and tyrosine hydroxylase (TH) by immunostaining in myocardial tissues\nwere measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>T2DM caused a significant increase in blood glucose, HOMA-IR index, serum CK-MB and\nLDH, myocardial damage and fibrosis, myocardial MDA, myocardial \u03b1-SMA, p53, caspase-3, Nrf2\nand TH density with a significant decrease in serum insulin and myocardial GSH and CAT (p&lt; 0.05).\nOn the other hand, treatment with either exercise or stevia R extracts significantly improved all studied\nparameters (p&lt; 0.05). Moreover, the effects of stevia R was more significant than exercise (p&lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Both exercise and methanolic stevia R extracts showed cardioprotective effects against\nDCM and Stevia R offered more cardioprotective than exercise. This cardioprotective effect of these\nlines of treatment might be due to attenuation of oxidative stress, apoptosis, sympathetic nerve density\nand fibrosis and upregulation of the antioxidant transcription factor, Nrf2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1871530320666200420084444","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T11:28:17Z","timestamp":1587382097000},"page":"1117-1132","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0239-175X","authenticated-orcid":true,"given":"Abdelaziz M.","family":"Hussein","sequence":"first","affiliation":[{"name":"Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2311-2238","authenticated-orcid":true,"given":"Elsayed A.","family":"Eid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrinology, Delta University for Science and Technology, Gamasa, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismaeel","family":"Bin-Jaliah","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, King Khalid University, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-5002","authenticated-orcid":true,"given":"Medhat","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-658X","authenticated-orcid":true,"given":"Lashin S.","family":"Lashin","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.2337\/dc14-S081","volume":"37","year":"2014","unstructured":"Diagnosis and classification of diabetes mellitus. 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