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Macrophage-like synoviocytes and fibroblast-like synoviocytes (synoviocytes)\nare crucial ingredients of synovium. Therein, a lot of research has focused on synoviocytes. Researches\ndemonstrated that TLR1, TLR2, TLR3, TLR4, TLR5, TLR6 TLR7 and TLR9 are expressed in synoviocyte.\nAdditionally, the expression of TLR2, TLR3, TLR4 and TLR5 is increased in RA synoviocyte.\nIn this paper, we review the exact role of TLR2, TLR3, TLR4 and TLR5 participate in regulating\nthe production of inflammatory factors in RA synoviocyte. Furthermore, we discuss the role of vasoactive\nintestinal peptide (VIP), MicroRNA, Monome of Chinese herb and other cells (Monocyte and T\ncell) influence the function of synoviocyte by regulating TLRs. The activation of toll-like receptors\n(TLRs) in synoviocyte leads to the aggravation of arthritis, comparing with angiogenesis and bone\ndestruction. Above all, TLRs are promising targets for managing RA.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200427115225","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T17:03:40Z","timestamp":1588007020000},"page":"1156-1165","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["TLRs Play Crucial Roles in Regulating RA Synoviocyte"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-1278","authenticated-orcid":true,"given":"Xuling","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang 421001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5122-7083","authenticated-orcid":true,"given":"Juncheng","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang 421001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6765-9278","authenticated-orcid":true,"given":"Xin","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang 421001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3543-1869","authenticated-orcid":true,"given":"Zhiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of University of South China, Hengyang 421001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s12276-019-0283-6","volume":"51","author":"Maeda Y.","year":"2019","unstructured":"Maeda Y.; Takeda K.; Host-microbiota interactions in rheumatoid arthritis. 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