{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:38:39Z","timestamp":1772620719402,"version":"3.50.1"},"reference-count":20,"publisher":"Bentham Science Publishers Ltd.","issue":"3","funder":[{"DOI":"10.13039\/501100006319","name":"Centre National pour la Recherche Scientifique et Technique (CNRST","doi-asserted-by":"publisher","award":["PPR\/2015\/35"],"award-info":[{"award-number":["PPR\/2015\/35"]}],"id":[{"id":"10.13039\/501100006319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Matthiola maroccana (Coss.) belongs to the Brassicaceae family and it is an\nendemic plant from Morocco.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The objective of the study was to evaluate the effect of aqueous extract of Matthiola maroccana\n(Coss.) on blood glucose levels in normal and diabetic rats.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The effect of single dose (6 hours) and daily oral administration for seven days of the Aerial\nPart Aqueous Extract (A.P.A.E) of Matthiola maroccana (Coss.) (M. maroccana) at a dose of 20\nmg\/kg body weight on blood glucose levels in normal and streptozotocin(STZ)-induced diabetic rats\nwas observed. Furthermore, body weight, oral glucose tolerance test, liver histopathological examination,\nphytochemical screening, and in vitro antioxidant activity of A.P.A.E were evaluated in this\nstudy.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The results showed that M. maroccana A.P.A.E exerts potent hypoglycemic and antihyperglycemic\neffects on normal and STZ-induced diabetic rats (p&lt;0.0001). Also, it was able to restore body\nweight in diabetic rats (p&lt;0.05). Furthermore, the aqueous extract has been shown to regenerate hepatic\ntissues in diabetic rats. Besides, A.P.A.E revealed the presence of several phytochemical constituents\n(polyphenols, flavonoids, tannins, saponins, alkaloids, sterols and terpenoids), and possessed\nantioxidant activity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In conclusion, our findings showed that A.P.A.E of M. maroccana (A.P.A.E MM) possesses\nsignificant antihyperglycemic and hypoglycemic activities.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200520095305","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T16:51:32Z","timestamp":1589993492000},"page":"434-440","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potent Antihyperglycemic Effect of an Endemic Plant from Morocco (Matthiola Maroccana Coss.) on Normal and Streptozotocin-Induced Diabetic Rats"],"prefix":"10.2174","volume":"21","author":[{"given":"Ayoub","family":"Amssayef","sequence":"first","affiliation":[{"name":"Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia,Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Lahrach","sequence":"additional","affiliation":[{"name":"Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia,Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Eddouks","sequence":"additional","affiliation":[{"name":"Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000, Errachidia,Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","year":"2019","unstructured":"Diabetes Atlas International Diabetes Federation (IDF)2019","journal-title":"Diabetes Atlas"},{"key":"ref=2","author":"Clark P.","unstructured":"Clark P.; McDonald T.; Diabetes Mellitus; The immunoassay handbook, 2013, pp. 783-794."},{"key":"ref=3","year":"2017","unstructured":"Diabetes Atlas International Diabetes Federation (IDF)2017","journal-title":"Diabetes Atlas"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.phrs.2018.01.015","volume":"130","author":"Xu L.","year":"2018","unstructured":"Xu L.; Li Y.; Dai Y.; Peng J.; Natural products for the treatment of type 2 diabetes mellitus: pharmacology and mechanisms. 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