{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:11:56Z","timestamp":1768277516564,"version":"3.49.0"},"reference-count":36,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["EMIDDT"],"published-print":{"date-parts":[[2021,2,12]]},"abstract":"<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Fetuin-A serves a dual function; its high levels are associated with metabolic\nsyndrome, type 2 diabetes, obesity, insulin resistance, and nonalcoholic fatty liver disease, and on the\nother hand, it serves as a potent inhibitor of ectopic vascular calcification. Due to the opposing findings,\nthe aim of the current study was to investigate serum fetuin-A levels in men with coronary artery\ndisease (CAD).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>In the case-control study, anthropometric and biochemical parameters were determined in 83\nmen (43 CAD patients and 40 control subjects). At last, the serum fetuin-A levels were measured using\nthe fetuin-A human enzyme-linked immunosorbent assay (ELISA) kit.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> A significant difference was detected among the two groups for triglyceride and cholesterol\nlevels (P=0.003 and P=0.002, respectively). The mean fetuin-A levels were determined 230.57 \u00b1 63.76\nand 286.35 \u00b1 64.07 \u03bcg\/ml for the control group and the CAD patients, respectively (P&lt;0.001). Fetuin-\nA was significantly correlated to the severity of CAD (r 0.393, P&lt;0.001) and associated with the risk\nof CAD in subjects (OR [CI] = 1. 144 [1.060-1. 235]; p = 0.001). A cut-off value of 237.4 \u03bcg\/ml had\ngood sensitivity (76.7%) and specificity (65.0%) for differentiating between two groups [area under\ncurve (AUC) = 0.732 (CI=0.621-0.842); p &lt; 0.001].<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Our results indicated that fetuin-A levels were positively correlated to the severity of\nCAD. The findings suggest that there is a possible link between pathogenic mechanisms of atherosclerosis\nand fetuin-A; however, more investigations are needed in this regard.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1871530320666200601164253","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T19:44:57Z","timestamp":1591040697000},"page":"338-344","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Positive Correlation between Circulating Fetuin-A and Severity of Coronary Artery Disease in Men"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-118X","authenticated-orcid":true,"given":"Reza","family":"Afrisham","sequence":"first","affiliation":[{"name":"Department of Laboratory Sciences, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8050-2534","authenticated-orcid":true,"given":"Maliheh","family":"Paknejad","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4031-4181","authenticated-orcid":true,"given":"Davod","family":"Ilbeigi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2623-1101","authenticated-orcid":true,"given":"Sahar","family":"Sadegh-Nejadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8765-4837","authenticated-orcid":true,"given":"Sattar","family":"Gorgani-Firuzjaee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0074-3077","authenticated-orcid":true,"given":"Mahmoud","family":"Vahidi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Sciences, Faculty of Paramedicine, AJA University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1161\/ATVBAHA.117.309700","volume":"37","author":"Chen X.","year":"2017","unstructured":"Chen X.; Zhang Y.; Chen Q.; Li Q.; Li Y.; Ling W.; Lower plasma fetuin-A levels are associated with a higher mortality risk in patients with coronary artery disease. 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